Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stem Cells, Extracellular Matrix and Signaling Pathways that Govern Skeletal Biology
Discussion Leader: Aris Economides (Regeneron Pharmaceuticals, Inc., USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Michael Elowitz (California Institute of Technology, USA)
"Combinatorial Signal Perception in the BMP Pathway"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Andrew McMahon (University of Southern California, USA)
"Organs to Organoids: Development and Application in the Mammalian Kidney"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Yu Yamaguchi (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Multiple Hereditary Exostoses: From Genetics to Pharmacological Intervention"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Developmental Biology
Discussion Leader: Terence Capellini (Harvard University, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
Mark Lewandoski (National Cancer Institute, NIH, USA)
"FGFs Signal to Mesenchymal Progenitors to Regulate Skeletal Patterning"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
Licia Selleri (University of California, San Francisco, USA)
"Making Faces: Variation of Forms in Evolution and Disease"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Thimios Mitsiadis (University of Zurich, Switzerland)
"One Flew over the Notch's Nest: Tooth Shape Variations and Enamel Defects"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Diana Carlone (Boston Children's Hospital, USA)
"CXXC Finger Protein 1 Is Required for BMP Signaling During the Initiation of Chondrogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"MMP14 Cleaves PTH1R, Regulating the Contribution of the Chondrocyte-Osteoblast Lineage Continuum to Bone"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Emma Wentworth (University of Connecticut School of Dental Medicine, USA)
"Identification of Regulatory Elements of Early Murine Tooth Bud Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Elazar Zelzer (Weizmann Institute of Science, Israel)
"Piezo2 Expressed in Proprioceptive Neurons Is Essential for Skeletal Integrity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Ernestina Schipani (University of Michigan, USA) and Roberta Faccio (Washington University in St. Louis, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Establishing Stem Cell Niches Within Bones and Teeth
Discussion Leader: Pamela Robey (National Institute of Dental and Craniofacial Research, NIH, USA)
7:30 pm - 8:00 pm
Noriaki Ono (University of Michigan School of Dentistry, USA)
"Dissecting the Bone Marrow Stromal Cell Lineage"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Gage Crump (University of Southern California, USA)
"Modular Control of Musculoskeletal Integration"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Chitra Dahia (HSS Research Institute, Weill Cornell Medicine, USA)
"SHH Regulates the Intervertebral Disc Niche for Its Growth and Regeneration"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Véronique Lefebvre (Children's Hospital of Philadelphia, USA)
"SOX9 Safeguards Growth Plate but Not Articular Chondrocytes from Osteoblastogenesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adult Skeleton Physiology
Discussion Leader: Lynda Bonewald (Indiana University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Maria Grano (University of Bari Aldo Moro, Italy)
"Crosstalk Between Muscle and Bone: Role of the Myokine Irisin"
9:40 am - 9:45 am
Discussion
9:45 am - 10:15 am
Gerard Karsenty (Columbia University , USA)
"Updates on the Endocrine Functions of Bone"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Teresita Bellido (Indiana University School of Medicine, USA)
"Osteocyte-Driven Bone Remodeling: Crosstalk Between Mechanical and Hormonal Signals"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
Christopher Hernandez (Cornell University, USA)
"Regulation of Bone by the Microbiome"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Johanna Bolander (KU Leuven, Belgium)
"A Cellular and Biomaterial Toolbox for the Development of a 3D In Vitro Engineered Bone Fracture Callus"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Takenobu Katagiri (Research Center for Genomic Medicine, Saitama Medical University, Japan)
"A Novel Molecular Mechanism for the Activation of a BMP Type I Receptor, ALK2, Proposed from Research on Fibrodysplasia Ossificans Progressiva"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Skeleton and Disease: Changes in Signals, Stem Cells and Niches
Discussion Leader: Larry Suva (Texas A&M University, USA)
7:30 pm - 7:55 pm
Amato Giaccia (Stanford University, USA)
"Hypoxia Regulation of Metastasis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Roberta Faccio (Washington University in St. Louis, USA)
"Systemic Tumor-Bone Communication: Role of Dkk1"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Sylvain Provot (INSERM, France)
"Systemic Control of Breast Cancer by the Skeleton"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Jill Helms (Stanford University, USA)
"Stem Cell Niches in the Oral Cavity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Skeletal Compartment Communication
Discussion Leader: Laura Calvi (University of Rochester, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
Thomas Clemens (Johns Hopkins University, USA)
"Role of Sensory Nerves in Bone Development and Repair"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
Christa Maes (KU Leuven, Belgium)
"Communication Between the Osteogenic, Angiogenic and Hematopoietic Compartments of the Developing and Postnatal Skeleton"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Joy Wu (Stanford University School of Medicine, USA)
"Crosstalk Between Osteoblasts and the Hematopoietic Marrow"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Amanda Huber (University of Michigan, USA)
"Genetic and Mobilization-Based Alteration in Mesenchymal Cell Fate"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Julian Berger (Columbia University Medical Center, USA)
"Rescue of Muscle Function by Osteocalcin in Sarcopenia"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Ryan Riddle (Johns Hopkins University School of Medicine, USA)
"Thermogenic and B-Adrenergic Induction of Sclerostin Suppresses Adipose Tissue Browning"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Terence Capellini (Harvard University, USA)
"Separate Regulatory Variants at GDF5-UQCC1 Underlie Developmental Dysplasia of the Hip and Knee Osteoarthritis Risk"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Technologies in Skeletal Biology
Discussion Leader: Karen Lyons (University of California, Los Angeles, USA)
7:30 pm - 8:00 pm
Aris Economides (Regeneron Pharmaceuticals, Inc., USA)
"Engineering Artificial BMP and BMP Receptor Variants to Explore the Mechanism of Signal Transduction"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Timothy Springer (Boston Children's Hospital / Harvard Medical School, USA)
"Extracellular Signaling in the TGF-β Family"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Jean Fan (Harvard University, USA)
"Spatially-Resolved Transcriptome-Scale Molecular Profiling by MERFISH Characterizes Sub-Cellular RNA Compartmentalization and RNA Velocity In Situ to Reveal Cell-Cycle Dependent Gene Expression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: April Craft (Boston Children's Hospital / Harvard Medical School, USA)
"A Single Cell Transcriptomic Comparison of Embryonic Limb Bud and ESC-Derived Skeletal and Joint Progenitors"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Aging Skeleton
Discussion Leader: Sundeep Khosla (Mayo Clinic College of Medicine, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
Charles O'Brien (University of Arkansas for Medical Sciences, USA)
"Distinct Mechanisms Underlie Cortical Versus Cancellous Bone Aging"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
Karl Jepsen (University of Michigan, USA)
"Inter-Individual Differences in Skeletal Aging"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Jennifer Westendorf (Mayo Clinic, USA)
"Hdac3 in Skeletal Development and Aging"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: David Ornitz (Washington University in St. Louis, USA)
"Regulation of Bone Growth and Osteocyte Survival by FGF Signaling Pathways"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Wentian Yang (Alpert Medical School, Brown University, USA)
"SHP2 Is Required for the Osteogenic Differentiation of OCPs by Suppressing Their Adipogenic Potential"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"YAP1 and TAZ Negatively Control Bone Angiogenesis and Osteogenesis by Limiting Hypoxia-Inducible Factor Signaling in Endothelial Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Ling Qin (University of Pennsylvania, USA)
"Single Cell Transcriptomics Identifies a Unique Adipocyte Population that Regulates Bone Marrow Environment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Repair and Regeneration of Bones and Teeth
Discussion Leader: Fanxin Long (Children's Hospital of Philadelphia, USA)
7:30 pm - 8:00 pm
Ralph Marcucio (University of California, San Francisco, USA)
"The Death of Dogma and the Transformation of Chondrocytes to Osteoblasts: A New Model of Bone Regeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Benjamin Alman (Duke University, USA)
"The Orchestration of Bone Repair: The Role of Monocytes, Macrophages and Osteoclasts"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Selected from Poster Abstracts: Qian Cong (Harvard School of Dental Medicine, USA)
"Genetic and Acquired Heterotopic Ossification Are Driven by a Self-Amplifying Positive Feedback Loop of Hedgehog Signaling"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: James Watt (Tulane University School of Medicine, USA)
"The Influence of Cellular Metabolism on Digit Regeneration"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure