Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Metabolism and Bone Cells
Discussion Leader: Fanxin Long (The Children's Hospital of Philadelphia and University of Pennsylvania, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Brendan Lee (Baylor College of Medicine, United States)
"Multi-omic Approach to Defining Novel Skeletal Human Phenotypes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Geert Carmeliet (KU Leuven, Belgium)
"Skeletal Cell Metabolism: Bystander or Driver"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Gerard Karsenty (Columbia University, United States)
"Embryogenesis and Homeostasis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Development of Skeleton and Teeth
Discussion Leader: Karen Lyons (University of California, Los Angeles, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Andrei Chagin (Karolinska Institute, Sweden)
"Evolution and Function of Secondary Ossification Centers"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"PTHR1 and MMP14 in the Chondrocyte Derived Osteoblast Lineage"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Hervé Kempf (IMoPA Laboratory, Nancy, France)
"Tracheal Calcification: Not so Crystal Clear!"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Véronique Lefebvre (Children's Hospital of Philadelphia, United States)
"Key Roles for the SOXC Genes in Developmental and Adult Bone Formation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Wanida Ono (University of Texas Health Science Center at Houston School of Dentistry, United States)
"PTHrP, Stem Cells and Tooth Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Terence Capellini (Harvard University, United States)
"The Developmental Genetics of the Human Pelvis and Knee"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Peter Fabian (Masaryk University, Czech Republic)
"Single-Cell Sequencing Reveals Specialized Fibroblasts for Protecting the Skeleton"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Deneen Wellik (University of Wisconsin-Madison, United States) and Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Origin and Fate of Bone Cells
Discussion Leader: Deneen Wellik (University of Wisconsin-Madison, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Vicki Rosen (Harvard School of Dental Medicine, United States)
"The Secreted Life of Periosteal BMP2"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Sarah Dallas (University of Missouri Kansas City, United States)
"Osteoclast and Osteocyte Dynamics in Bone"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Maria Almeida (University of Arkansas for Medical Sciences, United States)
"The Role of NAD in Mesenchymal Cells from Bone Development to Aging"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Diana Carlone (Boston Children's Hospital, United States)
"CXXC Finger Protein 1: A Gatekeeper of BMP Signaling and Skeletal Development"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cross Talks Among Hematopoietic, Endothelial and Bone Cells
Discussion Leader: Joy Wu (Stanford University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Laura Calvi (University of Rochester, United States)
"Macrophage-Osteolineage Cell's Cross Talk in Skeletal Homeostasis and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Anjali Kusumbe (University of Oxford, United Kingdom)
"Vascular Control of Skeletal Homeostasis and Regeneration"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Matthew Greenblatt (Weill Cornell Medicine, United States)
"A Stem Cell Mediating Osteoblast Versus Adipocyte Lineage Commitment"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Michelle McDonald (GARVAN INSTITUTE, Australia)
"Osteomorphs and Osteoclast Recycling: A Mechanism for Rebound Bone Loss Following Withdrawal of Denosumab Therapy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yuji Mishina (University of Michigan School of Dentistry, United States)
"New Modes for Spatio-Temporal Coupling of Bone Formation and Bone Resorption Governed by Osteoclasts"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Steve Stegen (KU Leuven, Belgium)
"De Novo Serine Synthesis Regulates Osteoclast Differentiation and Bone Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Contribution of Bone Marrow Adipocytes and Stroma to Bone Homeostasis
Discussion Leader: Pamela Robey (National Institute of Dental and Craniofacial Research, NIH, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Steven Teitelbaum (Washington University School of Medicine, United States)
"Fat Talks to Bone"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Ling Qin (University of Pennsylvania, United States)
"Marrow Adipogenic Lineage Precursor (MALP): A Master Regulator of Bone Metabolism and Marrow Environment"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Michaela Reagan (Maine Medical Center, United States)
"Bone Marrow Adipocytes, Sclerostin, and Myeloma"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Benjamin Alman (Duke University, United States)
"Splenic Derived Macrophages and the Expression of Extracellular Matrix Protein 1 (Ecm1) Regulates the Pace of Fracture Repair in Mature Mice"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microenvironment and Metabolism of Tumors and Normal Cells
Discussion Leader: Amato Giaccia (University of Oxford, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Rachelle Johnson (Vanderbilt University Medical Center, United States)
"Impact of Tumor-Targeted Therapies on Skeletal Health"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Florent Elefteriou (Baylor College of Medicine, United States)
"Importance of the Local Bone Microenvironment in NF1 Skeletal Dysplasias and Pseudarthrosis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Stavroula Kousteni (Columbia University, United States)
"Role of the Osteoblastic Niche in Acute Myeloid Leukemia Transformation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Jesus Delgado-Calle (UAMS, United States)
"The Osteocyte as a Signaling Cell in the Tumor Bone Microenvironment"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sinthu Pathmanapan (Hospital for Sick Children, Canada)
"Characterizing Glycogen Metabolism’s Role in Cartilage Development & in mutant IDH Chondrosarcomas"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Anyonya Guntur (Maine Medical Center, United States)
"Impaired Mitochondrial Stress Signaling in Osteoblasts Mediates Bone Loss in Male Mice in the Absence of BNIP3"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
The Tendon-Bone Unit and Healing Processes
Discussion Leader: Elazar Zelzer (Weizmann Institute of Science, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Megan Killian (University of Michigan, United States)
"Development, Disease, and Healing of the Enthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Kurt Hankenson (University of Michigan, United States)
"Callus Size Regulation During Compromised Bone Healing"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Robert Tower (University of Texas Southwestern Medical Center, United States)
"Spatial Transcriptomics Reveals Increased Energetic Requirements Underpinning Age-Dependent Declines in Digit Regeneration Rescued Through Administration of OAA"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Alexandra Tits (University of Liege, Belgium)
"Biomechanical and Biological Aspects of Mineralized Fibrocartilage at the Tendon-Bone Interface: a Multi-Modal Analysis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Katharine Hubert (University of Wisconsin-Madison, United States)
"Elucidating the Role of Hox Genes in Fracture Repair"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Rare Bone Diseases
Discussion Leader: Maurizio Pacifici (Children's Hospital of Philadelphia, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Thomas Gardella (Massachusetts General Hospital, United States)
"PTHR1 Mutations in Skeletal Disease and Potential Paths to Therapy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Laurence Legeai-Mallet (Institut Imagine-Inserm U1163-Université de Paris, France)
"Latest News Regarding FGFR3 Related Disorders"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
"New Insights into the Mechanism of Signaling by Fibrodysplasia Ossificans Progressiva (FOP)-mutant ACVR1"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Benjamin Levi (University of Texas Southwestern Medical Center, United States)
"The Nervous Niche of Musculoskeletal Tissue in Repair and Disrepair"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mary Adeyeye (University of Texas Medical Scientist Training Program, United States)
"Paradoxical Effect of Frizzled2-Fc on Bone Mass for the Treatment of Osteogenesis Imperfecta"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Efrosini Tsouko (Cuko) (Baylor College of Medicine, United States)
"Nf1 Deficiency-Induced Senescence in Osteoprogenitor Cells as a New Therapeutic Target for NF1 Pseudarthrosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regeneration of Bone
Discussion Leader: Yingzi Yang (Harvard School of Dental Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Jerome Guicheux (University of Nantes, Inserm UMR 1229, France)
"Novel Modalities of Joint Regeneration: When Developmental Biologists meet Tissue Engineers"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Matthew Silva (Washington University School of Medicine, United States)
"Role of Osteoblast Lineage Cell Proliferation in Fracture Healing"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Regina Brunauer (Texas A&M University, United States)
"Exploring the Microcosm of Mouse Digit Regeneration to Understand Bone Aging"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure