Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Definition, Location, and Function of Stem and Progenitor Cells
Discussion Leader: Christa Maes (KU Leuven, Belgium)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Noriaki Ono (University of Texas Health Science Center at Houston School of Dentistry, United States)
"Growth Plate Stem Cell Actions in Mosaicism"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Deneen Wellik (University of Wisconsin-Madison, United States)
"Hox Control of Osteochondral Differentiation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Heterogeneity and Functional Specialization of Endothelial Cells in Bone"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Aging and Inflammation
Discussion Leader: Maria Almeida (University of Arkansas for Medical Sciences, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Gabriel Mbalaviele (Washington University School of Medicine in St. Louis, United States)
"Complex Inflammasome-Mediated Inflammatory Responses in Bone Resorption"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Baohong Zhao (Hospital for Special Surgery, United States)
"Pathways Driving Inflammatory Osteoclastogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Megan Weivoda (Mayo Clinic, United States)
"Osteoclast Functional Heterogeneity During Aging"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Cun-Yu Wang (UCLA, United States)
"Epigenetic Control of Skeletal Aging by KDM4B"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Yingzi Yang (Harvard School of Dental Medicine, United States) and Megan Weivoda (Mayo Clinic, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Control of Bone and Tooth Development
Discussion Leader: Noriaki Ono (University of Texas Health Science Center at Houston School of Dentistry, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Ernestina Schipani (University of Pennsylvania, United States)
"Mitochondria and the Control of Skeletal Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Kim Cooper (University of California, San Diego, United States)
"What Big Feet You Have! Evolution of Skeletal Proportion in Bipedal Jerboas"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Ophir Klein (Cedars-Sinai and University of California, San Francisco, United States)
"Development and Renewal of the Dentition Using the Mouse Incisor as a Model"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Responding to Mechanical Signals
Discussion Leader: Matthew Silva (Washington University School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Karl Lewis (Cornell University, United States)
"New Tools, New Questions: Recent Advancements in Intravital Studies of Osteocyte Mechanobiology"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Joel Boerckel (University of Pennsylvania, United States)
"Targeting Fracture Gap Oxygenation for Bone Regeneration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Sarah Calve (University of Colorado Boulder, United States)
"ECM and Biomechanics"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Eileen Shore (University of Pennsylvania School of Medicine, United States)
"Biomechanical Signals and Heterotopic Ossification"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regeneration and Repair
Discussion Leader: Megan Killian (University of Michigan, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Anne George (University of Illinois at Chicago, United States)
"DPP in Tissue Regeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Yingzi Yang (Harvard School of Dental Medicine, United States)
"Hedgehog Signaling in Cranial Bone Regeneration"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Charles Chan (Stanford, United States)
"Cartilage Regeneration"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Rare Diseases
Discussion Leader: Emma Duncan (King's College London, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Kelly Wentworth (University of California, San Francisco, United States)
"Fibrous Dysplasia"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Anna Teti (Universita' dell'Aquila, Italy)
"Osteopetrosis: Nosology, Significance and Therapy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
"Treatment of FOP"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hormonal Impacts on the Skeleton
Discussion Leader: Murat Bastepe (Massachusetts General Hospital/Harvard Medical Sch, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Marc Wein (Massachusetts General Hospital, United States)
"Intracellular Mediators of PTH Action in Target Tissues"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Janet Crane (Johns Hopkins University, United States)
"Glucocorticoids Impact on the Growing Skeleton"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Martina Rauner (Technische Universität Dresden, Germany)
"Erythropoietin and Iron Effects on Bone"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Bone Cell Communication
Discussion Leader: Michelle McDonald (GARVAN INSTITUTE, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Elazar Zelzer (Weizmann Institute of Science, Israel)
"Tendon-Bone Communication"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Chrissy Hammond (University of Bristol, United Kingdom)
"Modelling Skeletal Ageing Phenotypes in Zebrafish"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Rafiou Agoro (The Jackson Laboratory, United States)
"Single Cell Cortical Bone Transcriptomics Define Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Brian Foster (The Ohio State University, United States)
"Bone Sialoprotein: From Bones to Teeth and Back Again"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer and Bone
Discussion Leader: Jesus Delgado-Calle (UAMS, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Hanna Taipaleenmäki (University Hospital, LMU Munich, Germany)
"Osteoblasts as Cellular Targets in Bone Metastasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Xiang Zhang (Baylor College of Medicine, United States)
"Bone Marrow Niches as Targets of Metastasis and Sources of Systemic Immune Suppression"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Colleen Wu (Duke University, United States)
"Targeting the HIF Signaling Pathway for the Radioprotection of Bone"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure