| SATURDAY |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Lecture |
| 3:15 pm - 3:45 pm | Dr. Henry Kronenberg (Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA)
"The Osteoblast Lineage and its Regulation" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | Teeth and Craniofacial Bones |
| Discussion Leaders: Dr. Christine Hartmann (Institute of Molecular Pathology, Vienna, Austria) and Manav Mehta (Harvard School of Engineering and Applied Sciences, Cambridge, MA, USA) |
| 5:30 pm - 5:45 pm | Keishi Otsu (Iwate Medical University, Iwate, Japan)
"Functional Role of Rho Signaling in Dental Epithelial Stem Cells" |
| 5:45 pm - 5:50 pm | Discussion |
| 5:50 pm - 6:05 pm | Olivier Duverger (NIAMS/NIH, Bethesda, MD, USA)
"Neural Crest Expression of Dlx3 is Essential for Craniofacial Bone Mineralization, Odontoblast differentiation, and Dentin Deposition" |
| 6:05 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Ines Bruckmann (HI-STEM, Heidelberg, Germany)
"The Influence of c-Myc Overexpressing Osteoblasts on the Interaction between Stem Cells and their Niche" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:45 pm | Lotta Veistinen (University of Helsinki, Helsinki, Finland)
"Calvarial Bone Phenotype of Gli3-/- Mice Is Independent of Ihh Signalling" |
| 6:45 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:05 pm | Johannes Keller (University Medical Center Hamburg-Eppendorf, Hamburg, Germany)
"Control of Bone Formation by the Calcitonin Receptor in Osteoclasts" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Masaki Ishikawa (NIDCR/NIH, Bethesda, MD, USA)
"Pannexin 3 Promotes Osteoblast Differentiation Through Its Function as an Endoplasmic Reticulum (ER) Ca2+ Channel, a Hemichannel and a Gap Junction" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Bone Development and Regeneration |
| Discussion Leaders: Dr. Henry Kronenberg (Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) and Renata Granito (INSERM U1059, Saint-Etienne, France) |
| 9:00 am - 9:15 am | Nunzia Di Maggio (Basel University Hospital, Basel, Switzerland)
"FGF-2 Maintains a Niche-Dependent Population of Self-Renewing Highly Potent Non-Adherent Mesenchymal Progenitors through FGFR2c" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Bjorn Behr (Stanford University School of Medicine, Stanford, CA, USA)
"Locally Applied VEGFA Increases the Osteogenic Healing Capacity of Human Adipose Derived Stem Cells by Promoting Osteogenic and Endothelial Differentiation" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Nick van Gastel (KU Leuven, Leuven, Belgium)
"Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Scott Roberts (KU Leuven, Leuven, Belgium)
"Ectopic Bone Formation by Human Periosteal Derived Cells Progresses through a Cartilaginous Intermediate" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | April Craft (University Health Network, Toronto, Canada)
"Regulation of Articular and Growth Plate Chondrocytes from Pluripotent Stem Cells" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Ryan Gillespie (University of Western Ontario, London, Ontario, Canada)
"The Roles of Glycogen Synthase Kinase 3 Beta in Cartilage and Bone Development" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Bones and Pathological Conditions |
| Discussion Leaders: Dr. Christine Hartmann (Institute of Molecular Pathology, Vienna, Austria) and Swati Biswas (Vanderbilt University Medical Center, Nashville, TN, USA) |
| 1:30 pm - 1:45 pm | Julianne Huegel (Thomas Jefferson University, Philadelphia, PA, USA)
"Mechanisms of Exostosis Formation in Hereditary Multiple Exostoses Syndrome" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Helen Owen (KU Leuven, Leuven, Belgium)
"Bone hyperresorption via spontaneous osteoclast differentiation in critical illness" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Katherine Motyl (Maine Medical Center Research Institute, Portland, ME, USA)
"The Second Generation Antipsychotic Risperidone Causes Bone Loss in C57BL/6J Mice as a Result of Direct and Indirect Effects on Bone Turnover" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
