SATURDAY |
2:00 pm - 5:00 pm | Arrival and Check-in |
3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:45 pm - 4:30 pm | Keynote Lecture |
3:45 pm - 4:15 pm | Andrew McMahon (Keck School of Medicine USC)
"Gene Regulatory Networks Governing Cartilage and Bone Programs"
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4:15 pm - 4:30 pm | Discussion |
4:30 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Developmental Biology of the Skeleton |
| Discussion Leaders: Maurizio Pacifici (Children's Hospital of Philadelphia) and Harunur Rashid (University of Alabama at Birmingham)
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7:30 pm - 7:42 pm | Shai Eyal (Weizmann Institute of Science)
"On the Development of the Patella"
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7:42 pm - 7:47 pm | Discussion |
7:47 pm - 7:59 pm | Pallavi Bhattaram (Cleveland Clinic)
"Critical Roles for SoxC Transcription Factors in Cell Fate Determination at the Onset of Skeletogenesis"
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7:59 pm - 8:04 pm | Discussion |
8:04 pm - 8:16 pm | Rebekah Cosden Decker (Children's Hospital of Philadelphia)
"Kartogenin Promotes Mouse Embryo Limb Joint Formation and Skeletal Growth through Modulation of Tgf-Beta Signaling"
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8:16 pm - 8:21 pm | Discussion |
8:21 pm - 8:33 pm | Jason Rockel (Hospital for Sick Children, Toronto)
"Hedgehog Signaling in Interzone Progeny Alters Cell Differentiation and Synovial Joint Morphogenesis by Inhibiting Beta-Catenin-Mediated Fgf18 Expression"
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8:21 pm - 8:33 pm | Discussion |
8:38 pm - 8:50 pm | Noriaki Ono (Massachusetts General Hospital)
"Early Mesenchymal Progenitors in Developing Bones Express Type II Collagen Gene"
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8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:07 pm | James Ferguson (Case Western Reserve University)
"Identifying the Mechanism of Ectodermal Wnts in Suppression of Ectopic Cartilage fate"
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9:07 pm - 9:12 pm | Discussion |
9:12 pm - 9:25 pm | Lick Pui Lai (University of Southern California)
"Stk11 (Lkb1) is a Key Gate Keeper of the Chondrocyte Development Program"
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9:25 pm - 9:30 pm | Discussion |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Skeletal Repair and Regeneration |
| Discussion Leaders: Steven Teitelbaum (Washington University School of Medicine, St. Louis) and Nunzia di Maggio (Basel University Hospital)
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9:00 am - 9:15 am | Sandeep Paul (University of Southern California)
"Chondrocyte-Derived Osteoblasts Regenerate Jawbone in Adult Zebrafish"
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9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Hu Zhao (Ostrow School of Dentistry)
"The Suture Mesenchyme Provides a Stem Cell Niche for Craniofacial Bones"
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9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Cuicui Wang (University of Rochester Medical Center)
"Loss of Notch Signaling in Skeletogenic Mesenchymal Stem Cells Results in Fracture Non-Union"
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9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Gurpreet Baht (University of Toronto)
"Reversing the Age of Fracture Repair"
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10:15 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Holly Weiss-Bilka (University of Notre Dame)
"The Effect of Chondrogenic Culture Conditions on Endochondral Bone Formation with Human Aadipose-Derived Stem Cells"
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10:35 am - 10:40 am | Discussion |
10:40 am - 10:55 am | Daniela Zwolanek (University of Veterinary Medicine Vienna)
"Beta1 Integrin Mediates Adhesion of MSC to Defective Cartilage and Bone"
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10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Understanding the Disease Process |
| Discussion Leaders: Brendan Lee (Baylor College of Medicine) and Katherine Motyl (Maine Medical Center Research)
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1:30 pm - 1:40 pm | Girish Ramaswamy (University of Pennsylvania)
"Effects of GNAS Inactivation on Bone Formation"
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1:40 pm - 1:45 pm | Discussion |
1:45 pm - 1:55 pm | Ingo Grafe (Baylor College of Medicine)
"Increased TGF-Beta Signaling is a Common Mechanism in Osteogenesis Imperfecta"
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1:55 pm - 2:00 pm | Discussion |
2:00 pm - 2:10 pm | Kyu Sang Joeng (Baylor College of Medicine)
"The Sway Mouse is a Murine Model of Osteogenesis Imperfecta Caused by WNT1 Mutations"
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2:10 pm - 2:15 pm | Discussion |
2:15 pm - 2:25 pm | Jie Shen (University of Rochester)
"Dnmt3b is a Critical Target Gene During the Development of Osteoarthritis"
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2:25 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |