Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Effects of Aging on Crosstalk Between the Skeleton and Muscle
Discussion Leader: Fanxin Long (Washington University School of Medicine, USA)
3:45 pm - 4:20 pm
Lynda Bonewald (Indiana University, USA)
"Effects of Aging on Crosstalk Between the Skeleton and Muscle"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Bone Formation and Repair
Discussion Leaders: Vicki Rosen (Harvard School of Dental Medicine, USA) and Jennifer Zieba (Baylor College of Medicine, USA)
7:30 pm - 7:40 pm
Alice Goring (University of Southampton, United Kingdom)
"Investigating a Role for Endothelial-Derived Growth Factors in Regulating Bone Mineralisation Following Osteoblast VEGF Deletion"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Christophe Merceron (University of Michigan, USA)
"Hypoxia-Inducible Factor 2 Alpha Is a Negative Regulator of Osteoblastogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Shek Man Chim (Harvard School of Dental Medicine, USA)
"BMPs and Activins Regulate Bone Mass Through the Competition of Shared Type 2 Receptors"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Maiko Omi (University of Michigan, USA)
"Molecular and Cellular Analyses of BMP-Dependent Coupling Signals Between Osteoclasts and Osteoblasts During Bone Remodeling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Jingyi Wu (Texas A&M University College of Dentistry, USA)
"Dental Epithelial Proteoglycans Mediate the Renewal of Mouse Incisors via FGF and WNT Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Mengrui Wu (Harvard School of Dental Medicine, USA)
"YAP and TAZ Play Opposite Roles in Osteogenesis in Early and Mature Osteoblasts"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jessica Hathaway-Schrader (Medical University of South Carolina, USA)
"Antibiotic Disruption of Gut Microbiota Dysregulates Osteoimmune Crosstalk in Post-Pubertal Skeletal Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Bone Diseases and Therapies
Discussion Leaders: Brendan Lee (Baylor College of Medicine, USA) and Marina Feigenson (Harvard School of Dental Medicine, USA)
9:00 am - 9:10 am
Dongsu Park (Baylor College of Medicine, USA)
"Paratenon Perivascular Cells Are a Distinct Postnatal Tendon Stem/Progenitor Subset Responsible for Tendon Repair In Vivo "
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Yu Shi (Washington University in St. Louis, USA)
"Gli1 Identifies Osteogenic Progenitor Cells in Embryonic and Postnatal Bone Formation as well as Fracture Repair"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Evan Buettmann (Washington University in St. Louis, USA)
"Post-Fracture Osteogenesis Is Impaired with Loss of Osteoblast Lineage Cell VEGFA"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Michael Sorkin (University of Michigan, USA)
"Recruited Monocyte/Macrophage Populations Promote Initial Inflammation and Propagate Ectopic Bone Formation Through Macrophage Secreted TGF-1 in a Model of Traumatic Heterotopic Ossification"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Anyonya Guntur (Maine Medical Center, USA)
"Overexpression of MitoNEET in Osteoblasts Leads to Impaired Bone Mass and Energy Metabolism in Mice"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Eileen Daley (Goldman School of Dental Medicine, Boston University, USA)
"Incretin Dysregulation of Lysyl Oxidase: A Novel Mechanism for Diabetic Osteopenia"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Anais Møller (Vejle Hospital / University of Southern Denmark, Denmark)
"Mechanism of Menopause-Induced Increase in Osteoclastic Bone Resorptive Activity"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Career Paths in Science
Discussion Leader: Joohyun Lim (Baylor College of Medicine, USA)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Career Paths in Science
Faye Chen (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
Brendan Lee (Baylor College of Medicine, USA)
Vicki Rosen (Harvard School of Dental Medicine, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes