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Bones and Teeth (GRS)

Gordon Research Seminar

From Understanding the Mechanisms Regulating the Skeleton to Developing Therapies

February 1 - 2, 2020

Chairs Hongyuan Zhang and David E. Maridas

Grand Galvez

2024 Seawall Boulevard

Galveston, Texas, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Bones and Teeth is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Many scientific questions remain about the physiological mechanisms that govern the homeostasis of the skeleton. Current research in bone biology aims to answer these questions in order to facilitate the development of novel therapies for skeletal diseases. At the 2020 Bones and Teeth GRS, we intend to focus on therapeutics for bone disorders: From understanding the mechanisms regulating the skeleton to developing therapies. We hope to introduce early career scientists to novel perspectives and innovative techniques by creating a bridge between basic and translational research.

Related Meeting

This GRS will be held in conjunction with the "Bones and Teeth" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Signaling Pathways and Mechanisms Regulating the Development, Maintenance and Repair of the Skeleton Our keynote session will set the stage for the seminar by introducing signaling pathways and mechanisms involved in the development, maintenance and repair of the skeleton. Dr. Lyons is a professor at UCLA and an accomplished senior scientist with numerous contributions to bone biology. Discussion Leader: Jason Long (Duke University, USA)
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:20 pm	Karen Lyons (University of California, Los Angeles, USA) "Cartilage and Bone Biology Matricellular Proteins BMP Signaling"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms Regulating the Skeleton Discussion Leader: Karen Lyons (University of California, Los Angeles, USA)
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 7:55 pm	Faisal Alshalawy (Texas A&M University, USA) "Endoplasmic Reticulum (ER) Stress Transducer IRE1a Regulates Postnatal Bone Development and Bone Marrow Homeostasis"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Beatriz Ibarra (Case Western Reserve University, USA) "Wnt Signaling Is Required for Phosphorylation of Erk1/2 During Murine Cranial Bone Development In Vivo"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Lisa Lawson (Washington University in St. Louis, USA) "Wnts Produced by Osteo-Lineage Cells Inhibit Bone Resorption and Are Required for Loading-Induced Bone-Formation in Adult Mice"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Jason Long (Duke University, USA) "Unique Populations of Skeletal Stem Cells Arise from the Growth Plate"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Shauni Loopmans (KU Leuven, Belgium) "Glucose Catabolism via the Pentose Phosphate Pathway Controls Chondrocyte Function During Bone Development"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Yuki Matsushita (University of Michigan School of Dentistry, USA) "Notch Effector Hes1 Marks an Early Perichondrial Progenitor Cells in Endochondral Bone Development"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Maiko Omi (University of Michigan School of Dentistry, USA) "Molecular and Cellular Analyses of BMP-Dependent Coupling Signals Between Osteoclasts and Osteoblasts During Bone Remodeling"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Pathologies of the Skeleton and Their Therapies Discussion Leader: Aris Economides (Regeneron Pharmaceuticals, Inc., USA)
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:25 am	Daniel Clark (University of California, San Francisco, USA) "The Aging Macrophage and Inflammatory Dysregulation Within Bone: Implications for Periodontal Disease"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	Adriana Carvalho (Maine Medical Center Research Institute, USA) "Sex-Differences of Morphine Impact on Bone Homeostasis: Sustained Exposure Is Associated with Bone Loss and Altered miRNA Profiles in Male Mice"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Eben Estell (Maine Medical Center Research Institute, USA) "Irisin Stimulates Osteoclast Differentiation and Function"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Julio Mejia (Baylor College of Medicine, USA) "A Novel Stem and Progenitor Cell Induced During Heterotopic Ossification"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	I-Wen Song (Baylor College of Medicine, USA) "Changes in 3D Genome Architecture During Chondrocyte Differentiation in the Pathogenesis of Human Skeletal Dysplasia"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	Ying Ru (Icahn School of Medicine at Mount Sinai, USA) "Human Osteogenic Differentiation of iPSC-Derived Osteogenic Progenitors Studied by Transcriptome and Network Analyses"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	Reut Shainer (National Institute of Dental and Craniofacial Research, NIH, USA) "Biglycan Regulates Inflammation and Bone Regeneration During Fracture Healing"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Navigating Career Paths in Science Discussion Leader: Johanna Bolander (KU Leuven, Belgium)
1:30 pm - 2:30 pm	Panel Discussion Navigating Career Paths in Science Aris Economides (Regeneron Pharmaceuticals, Inc., USA) Kristy Nicks (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA) Karen Lyons (University of California, Los Angeles, USA) Elizabeth Rendina-Ruedy (Vanderbilt University Medical Center, USA)
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by (1R13AR076878-01) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and all co-funding support provided by the National Institute On Aging (NIA), and the National Institute of Dental and Craniofacial Research (NIDCR). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Bones and Teeth

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