Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Role of Amino Acids in Osteoblast Differentiation and Bone Formation - More Than Just Protein Synthesis
Discussion Leader: Naomi Dirckx (University of Maryland, Baltimore, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Courtney Karner (University of Texas Southwestern, United States)
"The Role of Amino Acids in Osteoblast Differentiation and Bone Formation - More Than Just Protein Synthesis"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms and Stem Cells Regulating the Skeleton
Discussion Leader: Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 7:55 pm
Marco Angelozzi (Children's Hospital of Philadelphia, United States)
"SOX4 Inhibits Trabecular Bone Formation in Female Mice"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Lisanne Groeneveldt (KU Leuven, Belgium)
"Periosteum-Derived Cells From Craniofacial Area Could Serve as a Cell Source for Bone Tissue Engineering Purposes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Zhaoyang Liu (University of Southern California, United States)
"ADGRG6 Maintains Cartilage Homeostasis Through Gs/cAMP Signaling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Emily Moore (Harvard School of Dental Medicine, United States)
"The Primary Cilium Mediates BMP Signaling in Periosteal Cell Differentiation and Mechanotransduction"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Efrosini Tsouko (Cuko) (Baylor College of Medicine, United States)
"Nf1 Deficiency-Induced Senescence in Osteoprogenitor Cells as a New Therapeutic Target for NF1 Pseudarthrosis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Tim Herpelinck (KU Leuven, Belgium)
"An Integrated Single-Cell Atlas of the Skeleton From Development Through Adulthood"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Mary Adeyeye (University of Texas Medical Scientist Training Program, United States)
"Paradoxical Effect of Frizzled2-Fc on Bone Mass for the Treatment of Osteogenesis Imperfecta"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Metabolism and Microenvironment in Bone Homeostasis and Pathology
Discussion Leader: Emily Moore (Harvard School of Dental Medicine, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
Stephen Gadomski (National Institutes of Health, United States)
"Bone-Anabolic Cholinergic Neurons Maintain the Osteocyte Syncytium"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Naomi Dirckx (University of Maryland, Baltimore, United States)
"A Specialized Metabolic Pathway Regulates Osteoblast Citrate Deposition in Bone Mineral to Impact Mechanical Strength"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Samantha Costa (MaineHealth Institute for Research, United States)
"PD-L1 Expression Promotes Bone Marrow Immunosuppression and Bone Loss with Diet-Induced Obesity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sinthu Pathmanapan (Hospital for Sick Children, Canada)
"Characterizing Glycogen Metabolism’s Role in Cartilage Development & in Mutant IDH Chondrosarcomas"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Nicole Gould (Washington University in St. Louis, United States)
"Conditional Deletion of the Catalytic Subunit of NADPH Oxidase 2 in Late Osteoblasts/Osteocytes Results in Mild Osteopenia in Female Mice"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Luciana Yamamoto de Almeida (NIDCR, United States)
"Influence of B Cells in a Large-Scale Bone Regeneration Mouse Model"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Guoli Hu (University of Texas Southwestern Medical Center, United States)
"De novo Glutathione Biosynthesis is Essential for Osteoblast Differentiation by Establishing a Pro-Osteogenic Redox Environment"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: A Roadmap to Being Successful in Academia
Discussion Leader: Nicole Migotsky (Washington University in St. Louis, United States)
1:30 pm - 2:30 pm
Panel Discussion
A Roadmap to Being Successful in Academia
Terence Capellini (Harvard University, United States)
Gage Crump (University of Southern California, United States)
Michaela Reagan (Maine Medical Center, United States)
Nick van Gastel (de Duve Institute, UCLouvain, Belgium)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes