| SUNDAY, July 15th |
| 14.00-18.00 | Arrival and registration |
| 18.00-19.30 | Dinner |
| Session 1. | Clinical and neuropathological features of triplet repeat diseases |
| Chair: Nancy Wexler, Columbia University, USA |
| 19.30-20.10 | Barry Kremer, Nijmegen University, The Netherlands
"What can we learn from the clinical features of triplet repeat diseases?" |
| 20.10-20.50 | Marian DiFiglia, Massachusetts General Hospital, USA
"Pathogenesis of Huntington's Disease: Revelations from cell models" |
| 20.50-21.30 | Discussion Leader: Jang-Ho Cha, Massachusetts General Hospital, USA |
| 21.30- | Welcome reception in the Willits-Hallowell Conference Center |
| MONDAY, July 16th |
| 08.45-09.00 | Group photograph |
| Session 2. | Molecular genetics of triplet repeat diseases |
| Chair: Albert La Spada, University of Washington, USA |
| 09.00-09.30 | Leslie Thompson, University of California Irvine, USA
"Pathogenic mechanisms in Huntington's Disease" |
| 09.30-10.00 | Marcy E MacDonald, Massachusetts General Hospital, USA
"Molecular mechanism of Huntington's disease" |
| 10.00-10.30 | Discussion Leader: Harry T Orr, University of Minnesota, USA |
| 10.30-11.00 | Coffee break |
| Session 3. | CAG triplet repeat expansions in model organisms |
| Chair: Max Perutz, Cambridge University, UK |
| 11.00-11.30 | Anne Hart, Massachusetts General Hospital, USA
"Genetic analysis of polyglutamine toxicity in the C. elegans nervous system" |
| 11.30-12.00 | Nancy Bonini, University of Pennsylvania, USA
"Chaperone mediated suppression of neurodegeneration in Drosophila" |
| 12.00-12.30 | Discussion Leader: Allan Tobin, University of California Los Angeles, USA |
| 12.30-13.30 | Lunch |
| 16.30-18.00 | Monday afternoon poster session |
| 18.00-19.30 | Dinner |
| Session 4. | Transgenic mouse models of triplet repeat diseases |
| Chair: Gillian Bates, GKT School of Medicine, UK |
| 19.30-20.10 | Peggy Shelbourne, University of Glasgow, UK
"Modelling Huntington's disease in mice" |
| 20.10-20.50 | Ai Yamamoto, Columbia University, New York, USA
"Modelling Huntington's disease: The relationship between expression and toxicity" |
| 20.50-21.30 | Discussion Leader: Michael Hayden, University of British Columbia, Canada |
| 21.30- | Informal discussions and posters |
| TUESDAY, July 17th |
| Session 5. | Chemistry and intracellular handling of proteins with expanded polyglutamine tracts |
| Chair: Samuel Karlin, Stanford University, USA |
| 09.00-09.45 | Alfred L. Goldberg, Harvard Medical School, Boston, USA
"Cellular mechanisms for eliminating abnormal, potentially-toxic polypeptides" |
| 09.45-10.30 | Frederic Saudou, Institut Curie - Section Recherche, Orsay, France
"Neuroprotection and intracellular processing of huntingtin" |
| 10.30-10.50 | Coffee break |
| 10.50-12.30 | Discussion Leader: David Housman, Massachusetts Institute of Technology, USA |
| 12.30-13.30 | Lunch |
| 16.30-18.00 | Tuesday afternoon poster session |
| 18.00-19.30 | Dinner |
| Session 6. | Similarities between different protein inclusion disorders |
| Chair: Henry L Paulson, University of Iowa, USA |
| 19.30-20.10 | Kenneth H Fischbeck, NINDS, NIH, USA
"Kennedy's disease" |
| 20.10-20.50 | Benoit Giasson, University of Pennsylvania, Philadelphia, Pennsylvania, USA
"Synucleinopathies" |
| 20.50-21.30 | Discussion Leader: Anne Young, Massachusetts General Hospital, USA |
| 21.30- | Informal discussions and posters |
| WEDNESDAY, July 18th |
| Session 7. | The role of apoptosis in triplet repeat diseases |
| Chair: Shoji Tsuji, Niigata University, Japan |
| 09.00-09.45 | Junying Yuan, Harvard Medical School, Boston, USA
"Studying polyglutamine expansion diseases by chemical biological approaches" |
| 09.45-10.30 | Cheryl Wellington, University of British Columbia, Canada
"New insights into the pathogenesis of Huntington's Disease" |
| 10.30-10.50 | Coffee break |
| 10.50-12.30 | Discussion Leader: Christopher E Henderson, INSERM U 382, France |
| 12.30-13.30 | Lunch |
| 16.30-18.00 | Wednesday afternoon poster session |
| 18.00-19.30 | Dinner |
| Session 8. | Triplet repeat diseases, neurotoxins and disrupted cellular energy metabolism |
| Chair: Patrik Brundin, Wallenberg Neuroscience Center, Lund, Sweden |
| 19.30-20.10 | Timothy Greenamyre, Emory University, Atlanta, USA
"Defects of mitochondrial calcium handling in Huntington's disease" |
| 20.10-20.50 | Anthony Schapira, Royal Free Hospital, London, UK
"Mitochondrial dysfunction in Huntington's disease" |
| 20.50-21.30 | Discussion Leader: Michael Levine, University of California Los Angeles, USA |
| 21.30- | Informal discussions and posters |
| THURSDAY, July 19th |
| Session 9. | Special emphasis panel |
| 09.00-10.10 | Special emphasis panel: Transfering basic science into clinical trials: problems and possibilities. |
| Discussion leader: Steven M. Hersch, Massachusetts General Hospital, USA |
| 10.10-10.30 | Coffee break |
| The impact of DNA chip technology on triplet repeat disease research |
| Chair: James F Gusella, Massachusetts General Hospital, USA |
| 10.30-11.10 | James Olson, Fred Hutchinson Center, Seattle, USA
"Designing and interpreting microarray studies" |
| 11.10-11.50 | Hans Lehrach, Max Planck Institute for Molecular Biology, Berlin, Germany
"Protein-protein interactions in Huntington's disease: implications for therapy" |
| 11.50-12.30 | Discussion Leader: Ethan Signer, Massachusetts Institute of Technology, USA |
| 12.30-13.30 | Lunch |
| 18.00-20.00 | Banquet |
| Session 10. | Keynote speaker |
| Chair: Marie-Francoise Chesselet, University of California Los Angeles, USA |
| 20.00-21.30 | Huda Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, USA
"Repeat Rapport: Collaborating Against Glutamines" |
| 21.30- | Social |
| FRIDAY, July 20th |
| 09.00 | Departure |
