| SATURDAY |
| 2:00 pm | Check-In Begins |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Address |
| 3:15 pm - 3:45 pm | J. Paul Taylor (St. Jude Children's Research Hospital)
"Insights into the Pathogenesis of a Polyglutamine Disease Provide Approaches to Therapeutic Intervention" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Polyglutamine Protein Biology: Gain and Loss of Function Toxicity |
| Discussion Leader: Diane Merry (Thomas Jefferson University) |
| 7:30 pm - 7:45 pm | Christopher Reina (University of Pennsylvania)
"Cellular stress induces nuclear localization of ataxin-3" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Lise Munsie (McMaster University)
"The Huntington's Disease protein has a nuclear function in cell stress response" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Heather Montie (Thomas Jefferson University)
"Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Carly Desmond (McMaster University)
"Mediation of Huntingtin Nuclear Import Via Karyopherin Beta 2" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Austen Milnerwood (University of British Columbia)
"Evidence for augmented extrasynaptic NMDA receptor signaling in a transgenic mouse model of Huntington's disease" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:30 pm | Structured Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 9:35 am | Successful Grant Writing |
| 9:00 am - 9:25 am | Margaret Sutherland (NIH/NINDS)
"How to Successfully Navigate the Funding Maze - The Dos and Don'ts for Grant Submission" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 12:15 pm | Pathogenesis and Therapeutics of Polyglutamine Disease |
| Discussion Leader: Harry Orr (University of Minnesota) |
| 9:35 am - 9:50 am | Rebecca Aron (Gladstone Institute of Neurological Disease, University of California, San Francisco)
"Validation of Potential Genetic Modifiers of Huntington's Disease in Neuronal Cell Models" |
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:10 am | Jill Yersak (Thomas Jefferson University)
"The 11S Proteasomal Activator REGgamma Protects Transgenic SBMA Motor Neurons from DHT-Dependent Cell Death while Enhancing AR Aggregation" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:00 am | Edgardo Rodriguez-Lebron (University of Michigan)
"Optimizing RNAi as potential therapy for Spinocerebellar Ataxias" |
| 11:00 am - 11:05 am | Discussion |
| 11:05 am - 11:20 am | Nobuhiro Fukikake (National Center of Neurology and Psychiatry)
"Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Wanda Kwan (Gladstone Institute of Neurological Disease, University of California, San Francisco)
"Analysis of the Effects of Bone Marrow Transplantation in the YAC128 Mouse Model of Huntington's Disease" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Structured Discussion |
| 12:15 pm - 12:30 pm | GRS Evaluation |
| (Discuss request for a subsequent GRS; Fill out Evaluation Forms) |
| 12:30 pm | Lunch |
| 1:30 pm - 3:30 pm | Poster Session II |
| 3:30 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
