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CAG Triplet Repeat Disorders (GRS)

Gordon-Kenan Research Seminar

May 30 - 31, 2009
Chair Mary Y. Heng
Waterville Valley
56 Packard's Road
Waterville Valley, New Hampshire, United States
 Venue and Travel Information

Conference Description

Triplet repeats occur naturally throughout the genome. Triplet repeat disorders result when triplet repeat numbers expand above some critical threshold. How expanded triplet repeats result in a variety of human genetic disorders is a growing field and spans many interdisciplinary fields of study including genetics, pharmacology, biochemistry, cell biology, neurology, and psychiatry.

The goal of the Gordon Research Seminar (GRS) in triplet repeat disorders is to provide opportunities for graduate students and postdoctoral fellows to showcase their work in a collaborative atmosphere. The aim of this event is to provide a forum for young scientists to discuss and to present their innovative, unpublished findings in a supportive environment, to spur stimulating discussions led by recognized leaders in triplet repeat disorders, and to foster the growth of new ideas and form new interdisciplinary collaborations for future research.

Related Meeting

This GRS will be held in conjunction with the "CAG Triplet Repeat Disorders" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

SATURDAY
2:00 pmCheck-In Begins
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Address
3:15 pm - 3:45 pmJ. Paul Taylor (St. Jude Children's Research Hospital)
"Insights into the Pathogenesis of a Polyglutamine Disease Provide Approaches to Therapeutic Intervention"
3:45 pm - 4:00 pmDiscussion
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPolyglutamine Protein Biology: Gain and Loss of Function Toxicity
Discussion Leader: Diane Merry (Thomas Jefferson University)
7:30 pm - 7:45 pm Christopher Reina (University of Pennsylvania)
"Cellular stress induces nuclear localization of ataxin-3"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pm Lise Munsie (McMaster University)
"The Huntington's Disease protein has a nuclear function in cell stress response"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Heather Montie (Thomas Jefferson University)
"Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Carly Desmond (McMaster University)
"Mediation of Huntingtin Nuclear Import Via Karyopherin Beta 2"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Austen Milnerwood (University of British Columbia)
"Evidence for augmented extrasynaptic NMDA receptor signaling in a transgenic mouse model of Huntington's disease"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pmStructured Discussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 9:35 amSuccessful Grant Writing
9:00 am - 9:25 amMargaret Sutherland (NIH/NINDS)
"How to Successfully Navigate the Funding Maze - The Dos and Don'ts for Grant Submission"
9:25 am - 9:35 amDiscussion
9:35 am - 12:15 pmPathogenesis and Therapeutics of Polyglutamine Disease
Discussion Leader: Harry Orr (University of Minnesota)
9:35 am - 9:50 am Rebecca Aron (Gladstone Institute of Neurological Disease, University of California, San Francisco)
"Validation of Potential Genetic Modifiers of Huntington's Disease in Neuronal Cell Models"
9:50 am - 9:55 am Discussion
9:55 am - 10:10 am Jill Yersak (Thomas Jefferson University)
"The 11S Proteasomal Activator REGgamma Protects Transgenic SBMA Motor Neurons from DHT-Dependent Cell Death while Enhancing AR Aggregation"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:00 am Edgardo Rodriguez-Lebron (University of Michigan)
"Optimizing RNAi as potential therapy for Spinocerebellar Ataxias"
11:00 am - 11:05 am Discussion
11:05 am - 11:20 am Nobuhiro Fukikake (National Center of Neurology and Psychiatry)
"Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones"
11:20 am - 11:25 am Discussion
11:25 am - 11:40 am Wanda Kwan (Gladstone Institute of Neurological Disease, University of California, San Francisco)
"Analysis of the Effects of Bone Marrow Transplantation in the YAC128 Mouse Model of Huntington's Disease"
11:40 am - 11:45 am Discussion
11:45 am - 12:15 pmStructured Discussion
12:15 pm - 12:30 pmGRS Evaluation
(Discuss request for a subsequent GRS; Fill out Evaluation Forms)
12:30 pmLunch
1:30 pm - 3:30 pmPoster Session II
3:30 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Conference Links

Conference History CAG Triplet Repeat Disorders
Additional Fee Info

CAG Triplet Repeat Disorders
May 25 - 30, 2025


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