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CAG Triplet Repeat Disorders (GRS)

Gordon Research Seminar

June 4 - 5, 2011
Chair Lise N. Munsie
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on CAG Triplet Repeat Disorders is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is on topics impacting graduate student and post doctoral work in the field of CAG Triplet Repeat Disorders and will span basic cell biology and molecular mechanisms of disease to drug target discovery, potential therapies, and testing in higher order mammalian models. The seminar will feature talks from graduate students and post doctoral fellows, a keynote address from Dr. Kenneth Fischbeck and a career panel including representatives from industry, Cell Press and academia.

Related Meeting

This GRS will be held in conjunction with the "CAG Triplet Repeat Disorders" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

SATURDAY
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Address
3:15 pm - 3:45 pm Kenneth H. Fischbeck (NINDS)
"CAG Expansion Disorders - Pathogenic insights and therapeutic approaches"
3:45 pm - 4:00 pm Discussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmMolecular Mechanisms of Disease: Protein and RNA gain and loss of function
Discussion Leader: Beverly L. Davidson (University of Iowa)
5:30 pm - 5:45 pm Kevin N. Dietz (Massachusetts General Hospital)
"Investigating the normal function of huntingtin in Drosophila"
5:45 pm - 5:50 pm Discussion
5:50 pm - 6:05 pm Thorsten Mueller (University of Clinic Bonn)
"Phosphorylation of ATXN3 - a key event in SCA3 pathogenesis"
6:05 pm - 6:10 pm Discussion
6:10 pm - 6:25 pm Jacqueline Gire (University of California, Irvine)
"SUMO modification of huntingtin in HD pathogenesis"
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:45 pm Tao Zu (University of Florida)
"Expression and post-translational modification of proteins expressed by repeat associated non-ATG translation (RAN-translation)"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:05 pm Nicholas S. Caron (McMaster University)
"Measuring Fluorescence Lifetime in Living Cells Reveals Huntingtin Exon1 Structure at Nanometer Resolution"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:30 pm Structured Discussion
8:00 pmDinner
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPathophysiology of Neurodegeneration
Discussion Leader: Austen J. Milnerwood (University of British Columbia)
9:00 am - 9:15 am Ulrike Träger (UCL Institute of Neurology)
"Innate immune dysfunction in Huntington's disease"
9:15 am - 9:20 am Discussion
9:20 am - 9:35 am Ricardo Mouro Pinto (Harvard Medical School)
"Mlh1 - a genetic modifier of CAG repeat instability in HD CAG knock-in mice"
9:35 am - 9:40 am Discussion
9:40 am - 9:55 am Clare M. Gladding (University of British Columbia)
"Investigating the molecular mechanisms underlying increased extrasynaptic NMDA receptor localization in a mouse model of Huntington's Disease"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 am Renee R. Handley (University of Auckland Centre for Brain Research)
"Identifying early gene expression changes in a transgenic ovine model of Huntington's disease"
10:15 am - 10:20 am Discussion
10:20 am - 10:35 am Ryan L. Boudreau (University of Iowa)
"Improving the safety of RNAi therapy for polyQ-repeat diseases"
10:35 am - 10:40 am Discussion
10:40 am - 11:00 am Structured Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCareer Panel: Beyond the PhD in the field of CAG Triplet Repeat Disorders
1:30 pm - 1:45 pm James Palacino (Novartis)
"Introduction to industry research in neurodegenerative disorders"
1:45 pm - 1:50 pm Discussion
1:50 pm - 2:05 pm Meredith LeMasurier (Cell Press)
"Career opportunities as a journal editor"
2:05 pm - 2:10 pm Discussion
2:10 pm - 2:25 pm Deanna Marchionini (CHDI)
"Science careers at not-for-profit organizations"
2:25 pm - 2:30 pm Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Contributors

Conference Links

Conference History CAG Triplet Repeat Disorders
Additional Fee Info

CAG Triplet Repeat Disorders
May 25 - 30, 2025


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