| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Introductory Session: "The History of HD" |
| Discussion Leader: Emily Sontag (Stanford, USA) |
| 3:45 pm - 4:15 pm | David Housman (MIT, USA)
"Selected vignettes in HD Research carried out by the young and the restless" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I (Surnames A-K) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Emerging Methods and Models: Illuminating New Paths to Therapeutics |
| Discussion Leader: Lisa Ellerby (Buck Institute, USA) |
| 7:30 pm - 7:50 pm | Anna Parievsky (UCLA, USA)
"Alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease using optogenetics" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Jintang Du (Scripps Research Institute, USA)
"CTG·CAG triplet-repeat instability in DM1 iPSCs" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Laura Bowie (McMaster University, Canada)
"Using high content image analysis to identify potential drug treatments for Huntington's disease" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Megan Keiser (University of Iowa, USA)
"Gene therapies for spinocerebellar ataxia type 1" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Molecular Mechanisms of Disease |
| Discussion Leader: Vahri Beaumont (CHDI Foundation Inc., USA) |
| 9:00 am - 9:20 am | Leora Fox (Columbia University, USA)
"Elimination of Alfy in an inducible model of Huntington's disease" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Chiara Scaramuzzino (Italian Institute of Technology, Italy)
"Pathogenic interaction of PRMT6 and polyglutamine androgen receptor in SBMA" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Joseph Ochaba (University of California Irvine, USA)
"SUMOylation regulates the formation of insoluble mutant Huntingtin: relevance to HD pathogenesis" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Andreas Neuder (King's College London, UK)
"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II (Surnames L-Z) |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:45 pm | Pathophysiology of Neurodegeneration |
| Discussion Leader: Andy Lieberman (University of Michigan, USA) |
| 1:30 pm - 1:45 pm | Davina Hensman Moss (UCL, UK)
"The C9orf72 expansion is the most frequent genetic cause of HD-like disorders in a UK based population" |
| 1:45 pm - 1:55 pm | Discussion |
| 1:55 pm - 2:10 pm | Rana Soylu (Lund University, Sweden)
"Long-term metabolic effects of huntingtin expression in the hypothalamus" |
| 2:10 pm - 2:20 pm | Discussion |
| 2:20 pm - 2:35 pm | Bindu Diana Paul (Johns Hopkins University School of Medicine, USA)
"Depletion of cystathionine gamma lyase, the biosynthetic enzyme for cysteine, mediates neurodegeneration in Huntington's disease" |
| 2:35 pm - 2:45 pm | Discussion |
| 2:45 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
