| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Session: The History of Ataxias/SCA1 |
| Discussion Leader: Edward Green (German Cancer Research Center, Heidelberg, Germany) |
| 3:15 pm - 3:45 pm | Harry Orr (University of Minnesota, USA)
"Spinocerebellar Ataxia Type 1 (SCA1): Therapeutic Targets" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Emerging Methods and Models: Illuminating New Paths to Therapeutics |
| Discussion Leader: Bahareh Eftekharzadeh (Institute for Research in Biomedicine, Spain) |
| 5:30 pm - 5:50 pm | Hayley McLoughlin (University of Michigan, USA)
"Assessment of Adeno-Associated Virus 2/9 Delivery Routes for SCA3 RNAi Therapy" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Renee Handley (University of Auckland Centre for Brain Research, New Zealand)
"Metabolite Changes in the Huntington’s Disease Transgenic Sheep Model" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Kyle McHugh (University of Delaware, USA)
"Transcription Factor-Assisted Differentiation of iPSCs into Medium Spiny Neuron Progenitors" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Megan Krench (Massachusetts Institute of Technology, USA)
"A Drosophila Model of Huntington’s Disease-Like 2 Exhibits Nuclear Toxicity and Distinct Pathogenic Mechanisms from Huntington’s Disease" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Molecular Mechanisms of Disease |
| Discussion Leader: Leora Fox (Columbia University, USA) |
| 9:00 am - 9:20 am | Rebecca Aron (Gladstone Institutes, USA)
"Functional Specificity of Deubiquitinating Enzymes in Neurodegeneration" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Shyam Ramachandran (The Children's Hospital of Philadelphia, USA)
"Transcriptome-Wide Alternative Splicing in Huntington's Disease" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Rahul Mishra (Indian Institute of Technology Kanpur, India)
"Amyloid Nanospheres from Polyglutamine Rich Peptides: Assemblage Through an Intermolecular Salt Bridge Interaction" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | General Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Pathophysiology of Neurodegeneration |
| Discussion Leader: Matthew Parsons (University of British Columbia, Canada) |
| 1:30 pm - 1:45 pm | Alondra Schweizer Burguete (University of Pennsylvania, USA)
"Neuritic Localization of Microsatellite Repeat RNAs and Transport Granule Dysfunction in Neurodegenerative Disease" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Danny Galleguillos (Neuroscience and Mental Health Institute, University of Alberta, Canada)
"Ganglioside GM1 Modulates the Brain Immune Response in a Mouse Model of Huntington’s Disease" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Riccardo Cristofani (University of Milan, Italy)
"The Role of Dynein Mediated Transport in Mutated Androgen Receptor Clearance" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
