Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: A Scientific Journey: Passion, Flexibility and Collaboration
Discussion Leader: Philipp Trepte (Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Germany)
3:45 pm - 4:20 pm
Leslie Thompson (University of California, Irvine, USA)
"A Scientific Journey: Passion, Flexibility and Collaboration"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging
Methods and Models: Illuminating New Paths to Therapeutics
Discussion Leader: Shyam Ramachandran (Children's Hospital of Philadelphia, USA)
7:30 pm - 7:50 pm
Alexander Tereshchenko (University of Iowa, USA)
"The Role of the Cerebellum in Juvenile Huntington's Disease (JHD)"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Lauren Byrne (UCL Huntington's Disease Centre, United Kingdom)
"Towards a Readily Accessible Biofluid Biomarker for Huntington's Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Colleen Stoyas (University of California, San Diego , USA)
"Sirt1 Restores Proper Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7 (SCA7)"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Daniel Child (The Children's Hospital of Philadelphia, USA)
"Abnormal Cardiac mTORC1 Activity in Huntington Disease Mouse Models"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Molecular
Mechanisms of Disease
Discussion Leader: Gunasekhar Burra (Indian Institute of Technology Kanpur, India)
9:00 am - 9:20 am
Anne Steinhof (Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Germany)
"Mutant HTT Seeding Activity: A Marker of Disease Progression in Models of Huntington's Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Samir Nath (University of Michigan, USA)
"Proteasome Dysregulation in Spinobulbar Muscular Atrophy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Charlene Geater (University of California, Irvine, USA)
"Huntington's Disease in a Dish"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Radhia Kacher (CNRS / Pierre and Marie Curie University, France)
"zQ175 Knock-In Mouse Model Helps to Decipher the Neuroprotective Role of CYP46A1, the Cholesterol Degradation Enzyme, in Huntington's Disease"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Pathophysiology
of Neurodegeneration
Discussion Leader: Sarah Gardiner (Leiden University Medical Centre, The Netherlands)
1:30 pm - 1:45 pm
Frederick Arnold (Thomas Jefferson University, USA)
"Deficient Nuclear Export of Polyglutamine-Expanded Androgen Receptor Contributes to Toxicity in a Cell Model of Spinal and Bulbar Muscular Atrophy"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Anastasia Gromova (University of California, San Diego, USA)
"Elucidating Mechanisms of Skeletal Muscle-Driven Neurodegeneration in Spinal and Bulbar Muscular Atrophy"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Nikhil Ratna (National Institute of Mental Health and Neurosciences, India)
"Lithium in Huntington's Disease"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
