Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Huntington's Disease: Trials and Tribulations
Discussion Leader: Ronald Buijsen (Leiden University Medical Center (LUMC), The Netherlands)
3:15 pm - 3:45 pm
Edward Wild (Huntington's Disease Centre, Institute of Neurology, University College London, United Kingdom)
"Huntington's Disease: Trials and Tribulations"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Polyglutamine Diseases: Molecular Mechanisms Behind Neurodegeneration
Discussion Leader: Emily Machiela (University of Central Florida, USA)
5:30 pm - 5:50 pm
Sarah Hernandez (University of California, Irvine, USA)
"Aberrant Extracellular Matrix Signaling Through Integrins May Contribute to Blood-Brain Barrier Dysfunction in Huntington's Disease"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Lauren Moore (University of Michigan, USA)
"Impairments in Nucleocytoplasmic Transport and Loss of Nuclear Integrity in SCA3"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Rafael Alcalá Vida (Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), University of Strasbourg, France)
"Aberrant Regulation of Learning-Induced Epigenome and Transcriptome in Huntington's Disease Mouse Striatum"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Melanie Alpaugh (Centre de Recherche du CHU de Québec (CHUL), Université Laval, Canada)
"Untangling the Contribution of Tau to Huntington's Disease"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Targets for the Treatment of Polyglutamine Diseases
Discussion Leader: Lauren Byrne (Huntington's Disease Centre, Institute of Neurology, University College London, United Kingdom)
9:00 am - 9:20 am
Branduff McAllister (Cardiff University, United Kingdom)
"Whole Exome Sequencing and Regression Analyses Identify Damaging DNA Repair Variants Associated with Altered Age at Onset in Huntington's Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Celeste Suart (McMaster University, Canada)
"Ataxin-1 Localizes to DNA Damage in an ATM-Dependent Manner"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Emma Bunting (University College London, United Kingdom)
"MSH3 Modifies Somatic Instability and Disease Severity in Huntington's and Myotonic Dystrophy Type 1"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Philipp Trepte (Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Germany)
"Systematic Interaction Mapping to Define the Quantitative Huntingtin Interactome"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Advances in Modifiers, Models and Drug Discovery
Discussion Leader: Avinash Gahane (Indian Institute of Technology Kanpur, India)
1:30 pm - 1:45 pm
Jasmine Donaldson (Cardiff University, United Kingdom)
"Effect of FAN1 Knock-Out on CAG Repeat Expansions and Associated Phenotypes in iPSC Models of Huntington's Disease"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Andrea Reyes-Ortiz (University of California, Irvine, USA)
"Evaluating the Contribution of Astrogliosis to Huntington's Disease Pathogenesis"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Maria Lucia Pigazzini (Leibniz Institute for Molecular Pharmacology (FMP), Germany)
"Tracking Huntingtin Interaction In Vivo and Its Interaction with the Proteostasis Network"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
