Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Ca2+ Channels
Discussion Leader: Henry Colecraft (Columbia University, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
Juan Du (Van Andel Institute, United States)
"Calcium Signaling in Taste Perception"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Xiaowei Hou (Memorial Sloan Kettering Cancer Center, United States)
"Structural Studies Reveal Insights into CRAC Channel Activation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Jean-Ju Chung (Yale School of Medicine, United States)
"3D Structure and In Situ Arrangements of CatSper Channel"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Vikas Arige (Yule Lab, C/O Prof. David I Yule, United States)
"Functional Determination of Calcium Binding Sites Required for the Activation of Inositol 1,4,5-trisphosphate Receptors"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
STIM-Dependent Signaling
Discussion Leader: Kenneth Stauderman (CalciMedica, Inc., United States)
9:00 am - 9:20 am
Peter Stathopulos (University of Western Ontario, Canada)
"Mimicking S-Glutathionylation: Structural Insights Into STIM1 Regulation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rainer Schindl (Medical University Graz, Austria)
"Mechanism of Luminal STIM1 Activation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yousang Gwack (UCLA, United States)
"Vesicle Trafficking Mechanism to Argument Store-Operated Ca2+ Entry"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Khaled Machaca (Weill Cornell Medicine Qatar, Qatar)
"STIM1 Hypomorph Mouse Model"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Paul Rosenberg (Duke University School of Medicine, United States)
"STIM1 and Cytoskeleton: Keeping Organellar Ca2+ Straight"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Salvatore Mancarella (UTHSC, United States)
"Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation."
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Benjamin Tripoli (Uniformed Services University of the Health Sciences, United States)
"Septins Regulate Heart Contractility Through Modulation of Cardiomyocyte Store-Operated Ca 2+ Entry"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Grace Stutzmann (Chicago Medical School, Rosalind Franklin University of Medicine and Science, United States) and Sandip Patel (University College London, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
TRP Channel Function
Discussion Leader: Thomas Gudermann (LMU Munich, Germany)
7:30 pm - 7:50 pm
Rudi Vennekens (KU Leuven, Belgium)
"Exploring the Role of TRPM4 in Calcium Dependent Triggered Activity and Cardiac Arrhythmias"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Michael Zhu (University of Texas Health Science Center at Houston, United States)
"TRP Channels in Information Coding, Pain and Itch"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ivana Kuo (Loyola University Chicago, United States)
"Intracellular TRPs as Sensors of the Environment"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Christina Humer (Johannes Kepler University (JKU) Linz, Austria)
"TRPV6 Regulation by Cis-22a and Cholesterol"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ehsan Kheradpezhouh (Australian National University, Australia)
"Enhanced Detection Behavior in Mouse Vibrissal Cortex Through TRPA1"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondrial Ion Channels
Discussion Leader: Madesh Muniswamy (University of Texas Health San Antonio, United States)
9:00 am - 9:20 am
Luca Scorrano (University of Padua, Italy)
"A Genome Wide Screening Identifies Tethers and Spacers at the Mitochondria-Endoplasmic Reticulum Interface"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
John Elrod (Temple University, United States)
"Calcium Control of Mitochondrial Cristae Structure and Function"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Alex Whitworth (University of Cambridge, United Kingdom)
"Applying Drosophila Genetics to Mitochondrial Calcium Flux and Neurodegeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lan Wei-LaPierre (Univeristy of Florida, United States)
"Mitochondrial Ca2+ Uptake, A Potential New Therapeutic Target for Amyotrophic Lateral Sclerosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Dipayan Chaudhuri (University of Utah, United States)
"The Mitochondrial Calcium Uniporter Compensates for Complex I Dysfunction"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mayara Bertolini (University of Georgia, United States)
"Exploring the Relation Between MICU1 and MICU2 in Trypanosoma cruzi by Generation of TcMICU1/TcMICU2-KO Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sandrine Pouvreau (INSERM U1215, France)
"Mitochondrial CB1 Receptors Tune Calcium Dynamics in Astrocytes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intracellular Ion Channels
Discussion Leader: Susan Hamilton (Baylor College of Medicine, United States)
7:30 pm - 7:50 pm
Sandip Patel (University College London, United Kingdom)
"Changing Channels: How TPC2 is Activated by its Ligands"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Irina Serysheva (University of Texas Health Science Center at Houston, United States)
"Structural Dynamics Underlying Gating and Regulation in IP3R Channel"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sebastian Brauchi (Universidad Austral de Chile , Chile)
"Imaging the Electrical Activity of Organelles"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Gihan Gunaratne (Medical College of Wisconsin, United States)
"Co-Regulation of NAADP Signaling by JPT2 and LSM12"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Valerie Brock (University Medical Center Hamburg-Eppendorf, Germany, Germany)
"P2X4 and P2X7 are Essential Players in Basal T Cell Activity and Ca2+ Signaling Milliseconds After T Cell Activation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Calcium Signaling and Neuro(patho)physiology
Discussion Leader: Cecilia Hidalgo (Universidad de Chile, Chile)
9:00 am - 9:20 am
Hilmar Bading (Heidelberg University, Germany)
"Disrupting the NMDAR/TRPM4 Signalosome Using Interface Inhibitors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elizabeth Jonas (Yale University, United States)
"ATP Synthase C-Subunit Leak Channel in Neuronal Developmental and Degenerative Disorders"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Brian Bacskai (Harvard Medical School, United States)
"Calcium Dysregulation in Mouse Models of Alzheimer's Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Wayne Chen (University of Calgary, Canada)
"Mechanism of RyR2-Dependent Modulation of Neuronal Hyperactivity in Alzheimer’s Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Gulnaz Begum (University of Pittsburgh, United States)
"Astrocytic Ion Transport Dysregulation in Stroke Induced Brain Damage"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sarah Hopp (UT Health Science Center San Antonio, United States)
"Cav1.2 Regulates Microglia Phenotype and Influences Behavior in Neuroinflammation, Alzheimer’s Disease, and Parkinson’s Disease Models"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Amreen Mughal (University of Vermont, United States)
"Electro-Calcium Signaling in the Brain Endothelium: A Higher Order Mechanism to Control Cerebral Blood Flow"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Calcium Sensors
Discussion Leader: Loren Looger (Howard Hughes Medical Institute, United States)
7:30 pm - 7:50 pm
Yubin Zhou (Texas A&M University, United States)
"Genetically-Encoded Calcium Channel Actuators and Blockers"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Yan Zhang (Howard Hughes Medical Institute, United States)
"Fast and Sensitive GCaMP Calcium Indicators for Neuronal Imaging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Arnab Mukherjee (University of California Santa Barbara, United States)
"Genetic Methods to Image Calcium with Magnetic Resonance - Preliminary Concepts and Proof-of-Principle"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Joseph Dynes (University of California, Irvine, United States)
"Photo-Inactivation Disrupts Rapid Fluorescence Readout of jGCaMP8 Ca2+ Indicators Tethered to Orai1"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ahmed Eltanahy (University of Nevada Reno, School of Medicine, United States)
"Light Sensitive Ca2+ Signaling in Choriocapillaris Endothelial Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Calcium Signaling and Disease
Discussion Leader: Barbara Niemeyer (University of Saarland, Germany)
9:00 am - 9:20 am
Johanna Lanner (Karolinska Institutet, Sweden)
"Illuminating Ca2+ and Mitochondrial Alterations linked to Muscle Dysfunction in Non-Communicable Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Natasha Prevarskaya (INSERM DR LILLE, France)
"Hallmarks of Cancer: New Dimensions in Calcium Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Saverio Gentile (Medical University of South Carolina, United States)
"Cancer: Ion-Channels - How Studying Ca2+ Signaling Unveils Cancer Vulnerability"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ágnes Enyedi (Semmelweis University, Hungary)
"Plasma Membrane Ca2+ Pump PMCA4 in Actin Cytoskeleton Remodeling, Cell Migration and Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michal Hershfinkel (Ben-Gurion University of the Negev, Israel)
"Zinc Activates ZnR/GPR39-Dependent Ca2+ Signaling to Regulate Ion Composition of the Saliva"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jillian Weissenrieder (University of Pennsylvania, United States)
"The Mitochondrial Calcium Uniporter In Pancreatic Ductal Cell Adenocarcinoma Growth, Proliferation, and Metastasis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Rodrigo Lacruz (New York University, United States)
"SOCE Regulates MMP-1 Expression Modulating the Transformation of Dysplasia to Oral Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Local Calcium Signaling in Plasticity and Disease
Discussion Leader: Ilya Bezprozvanny (University of Texas Southwestern Medical Center, United States)
7:30 pm - 7:50 pm
Klaus Groschner (Medical University of Graz, Austria)
"DAG Binding to the L2 Lipidation Site Sensitizes TRPC3 to Enable Fast Activation and High-Activity Ca2+ Signaling Mode"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Raz Palty (Technion - Israel Institute of Technology, Israel)
"The SOAR of STIM1 Interacts with Plasma Membrane Lipids to Form ER-PM Contact Sites"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Richard Tsien (New York University Grossman School of Medicine, United States)
"Calcium Regulation Genes: Diseases of Young and Old"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure