SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | State of the Art |
| Discussion Leader: Tullio Pozzan (University of Padova) |
7:40 pm - 8:05 pm | Loren Looger (Janelia Farms) "New Tools for Measuring Calcium" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Jenny Yang (Georgia State University)
"Design and Application of a Novel Class of Sensors to Monitor Ca2+ Dynamics in High Ca2+ Concentration Cellular Compartments" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Andrew Thomas (University of Medicine and Dentistry, New Jersey) "Calcium Signaling - State of the Art" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Insights into Mechanisms of Ca2+ Release from ER Stores |
| Discussion Leader: Barbara Ehrlich (Yale University) |
9:00 am - 9:25 am | Daniel Mak (University of Pennsylvania)
"Rapid Kinetic Responses of Single InsP3R Ca2+ Release Channels" |
9:25 am - 9:45 am | Discussion |
9:45 am | Group Photo / Coffee Break |
10:15 am - 10:40 am | Ian Parker (University of California, Irvine) "Imaging Ca2+ Fluxes Through Single Release Channels" |
10:40 am - 11:00 am | Discussion |
11:00 am - 11:15 am | William Ross (New York Medical College) "Calcium Sparks in Pyramidal Neuron Dendrites" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Gopal Velmurugan (Rosalind Franklin University) "Calcium Homeostasis in Vascular Smooth Muscle Cells is Altered in Type 2 Diabetes by Bcl-2 Protein Modulation of InsP3R Ca2+ Release Channels" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Irina Serysheva (University of Texas) "Cryo-EM studies of InsP3R at Subnanometer Resolution" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Organellar Ca2+ Signaling |
| Discussion Leader: Shmuel Muallem (NIH) |
7:30 pm - 7:55 pm | Hiroshi Takeshima (Kyoto University) "TRIC Channel Subtypes, Willing Partners with Ca2+ Release Channels in Intracellular Stores" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Michael Zhu (University of Texas Health Sciences Center) "Two-pore Channels in Calcium Signaling Originating From Acidic Organelles" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Haoxing Xu (University of Michigan)
"Ca2+ release channels in the lysosome" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Plasma Membrane Ca2+ Influx |
| Discussion Leader: Indu Ambudkar (NIH) |
9:00 am - 9:25 am | Yuoxing Jiang (Univ Texas Southwestern Medical Center) "Structural Bases of Ca2+ Permeation and Regulation" |
9:25 am - 9:45 am | Discussion |
9:45 am | Coffee Break |
10:15 am - 10:40 am | Murali Prakriya (Northwestern University) "Permeation and Gating Mechanisms in ORAI Channels" |
10:40 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Jack Roos (CalciMedica, Inc) "Drug Discovery Targeting CRAC Channels" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:55 am | Kyle Cunningham (Johns Hopkins University) "The VGCC of Fungi: New Subunits, Regulators, Functions, and Connections with Intracellular Organelles" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Christian Blenn (University of Zurich) Poly(ADP-ribose)glycohydrolase is an Upstream Regulator of Ca2+ Fluxes in Oxidative Cell Death" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of Plasma Membrane Ca2+ Influx |
| Discussion Leader: Donald Gill (Temple University) |
7:30 pm - 7:55 pm | Amy Lee (Emory University) "Regulation of Ca2+ Channels by Protein Complexes" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Dan Minor (Univ California, San Francisco) "Structural and Functional Insights into Calcium Channel Modulation" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Eitan Reuveny (Weizmann Institute) "Identification of SERAF, a Novel Regulator of SOC Entry" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial Calcium |
| Discussion Leader: Gyorgy Hajnoczky (Thomas Jefferson University) |
9:00 am - 9:25 am | Robert Balaban (NIH)
"Mitochondrial Ca2+ and Cell Bioenergetics" |
9:25 am - 9:45 am | Discussion |
9:45 am | Coffee Break |
10:10 am - 10:20 am | Carl White (Rosalind Franklin University) "Interaction Between Bcl-xL and VDAC Regulates Mitochondrial Ca2+ in the Absence of Apoptotic Stimuli"
|
10:20 am - 10:30 am | Discussion |
10:30 am - 10:55 am | Israel Sekler (Ben-Gurion University, Israel) "NCLX and Mitochondrial Na/Ca2+ Exchange" |
10:55 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Rosario Rizzuto (University of Padua)
"Molecular characterization of mitochondrial calcium uptake" |
11:40 am - 12:05 pm | Fabiana Perocchi (Harvard University) "Integrative Genomics of Mitochondrial Ca2+ Uptake" |
12:00 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Calcium Signaling Physiology |
| Discussion Leader: Jim Putney (NIH) |
7:30 pm - 7:55 pm | Alexi Tepikin (University of Liverpool)
"Ca2+ Signaling in Exocrine Secretory Cells" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:20 pm | Ariel Quintana (La Jolla Inst. Allergy and Immunology) "Ca2+ Microdomains at the Immunological Synapse: How ORAI Channels, Mitochondria and Ca2+ Pumps Generate Local Ca2+ Signals for Efficient T-cell Activation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Mark Nelson (University of Vermont)
"Endothelial TRPV4 Sparklets: Elementary Ca2+ Signals That Regulate Vascular Function" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Jonathan Marchant (University of Minnesota) "Opposing Roles of Voltage-Gated Ca2+ Channels in Neuronal Control of Hedgehog Signaling and Stem Cell Differentiation in vivo"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ca2+ as Life and Death Signals |
| Discussion Leader: Beth Stutzmann (Rosalind Franklin University) |
9:00 am - 9:25 am | Hilmar Bading (University of Heidelberg, Germany) "Nuclear Calcium Signaling, Gene programs and Neuroprotection Induced by Synaptic Activity" |
9:25 am - 9:45 am | Discussion |
9:45 am | Coffee Break |
10:15 am - 10:40 am | Cecilia Hidalgo (University of Chile) "Ryanodine receptor-mediated calcium release in neuronal synaptic plasticity" |
10:40 am - 11:00 am | Discussion |
11:00 am - 11:25 am | James Surmeier (Northwestern University) "Ca2+ Homeostasis, Selective Vulnerability and Parkinson's Disease" |
11:25 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Ricardo Dolmetsch (Stanford University) "iPS Cells For Studying Ca2+ Channel Signaling in Neurological Diseases" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Late Breaking Science |
| Discussion Leader: Martin Bootman (The Babraham Institute) |
7:30 pm - 7:45 pm | Tomoki Matsuda (Res Inst Electronic Science, Japan) "Photoactivatable Ca2+ Indicator to Visualize Biological Events in Single Arbitrary Cells Within Tissues / Whole Body"
|
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Teresa Alonso (Inst of Biology and Molecular Genetics, Spain)
"Calcium Homeostasis Modulator 1 (CALHM1) Reduces the Ca2+ Content of the Endoplasmic Reticulum and Triggers ER Stress" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 9:05 pm | Keynote Lecture: David Clapham (Childrens' Hospital, Boston) "Calcium: a Fossil's View" |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |