Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Calcium and Cell Function; Cells, Organs and Organisms
Discussion Leader: Tullio Pozzan (Neuroscience Institute, National Research Council (CNR), Italy)
7:40 pm - 8:05 pm
Ole Petersen (School of Biosciences, Cardiff University, United Kingdom)
"Calcium and the Pancreas: In Vitro and In Vivo Studies"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Bradley Launikonis (The University of Queensland, Australia)
"Calcium Entry in Skeletal Muscle"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
David Paterson (University of Oxford, United Kingdom)
"Pre-Synaptic Calcium Channels, Cyclic Nucleotides and the Heart"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Nicola Hamilton-Whitaker (University College London, United Kingdom)
"Calcium Flux Through TRPA1 Channels and Myelin Damage"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into Ca2+ Stores and Intracellular Calcium Channels
Discussion Leader: Katsuhiko Mikoshiba (RIKEN Brain Science Institute, Japan)
9:00 am - 9:25 am
Maike Glitsch (University of Oxford, United Kingdom)
"Regulation of Receptor-Dependent Calcium Release by Environmental Stiffness"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
David Yule (University of Rochester, USA)
"Proteolytic Regulation of IP3 Receptor Function"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
Galina Schmunk (University of California, Irvine, USA)
"Defective IP3 Receptor-Mediated Calcium Signalling in Diverse Monogenic Autism Syndrome"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Masamitsu Iino (Nihon University School of Medicine, Japan)
"Calcium Release: The View from Inside the Stores"
11:30 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Andreas Guse (University Medical Center Hamburg-Eppendorf, Germany)
"Integration of NAADP-Dependent Calcium Signalling"
12:10 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Maike Glitsch (University of Oxford, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Restricting Ca2+ Signals Spatially: Micro- and Macrodomains
Discussion Leaders: Gary St. John Bird (National Institute of Environmental Health Sciences, NIH, USA) and Mohamed Trebak (Pennsylvania State University, USA)
6:00 pm - 6:25 pm
Erwin Neher (Max Planck Institute for Biophysical Chemistry, Germany)
"Short-Term Plasticity in the Calyx of Held"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Tamas Balla (National Institute of Child Health and Human Development, NIH, USA)
"PIP2 Dynamics and Transport at Membrane Junctions"
7:05 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Alexei Tepikin (University of Liverpool, United Kingdom)
"Local Calcium Signalling at ER-PM Junctions"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Gating of Orai1 Channels
Discussion Leader: James Putney (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:25 am
Christoph Romanin (Johannes Kepler University Linz, Austria)
"Molecular Basis of STIM-Orai Interaction"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Patrick Hogan (La Jolla Institute for Allergy and Immunology, USA)
"Gating of Orai Channels"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Shmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, USA)
"Control of Calcium Channels by Local PIP2 Microdomains"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:40 am
Donald Gill (Pennsylvania State University, USA)
"STIM1 Binding Site Nexus Remotely Controls Orai1 Channel Gating"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Richard Lewis (Stanford University, USA)
"Conformational Dynamics of the STIM1 Cytosolic Domain"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
VOCCs and TRPS
Discussion Leader: Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA)
6:00 pm - 6:25 pm
Joerg Striessnig (University of Innsbruck, Austria)
"Cav1.3 L-Type Calcium Channels in Brain Disorders"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Annette Dolphin (University College London, United Kingdom)
"New Insight into α2δ Regulation of Neuronal N-Type Calcium Channels"
7:05 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Reinhold Penner (The Queen's Medical Center / University of Hawaii, USA)
"Regulation of CRAC Channels by the 'Chanzyme' TRPM7"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondrial Ca2+ Dynamics
Discussion Leader: Andrew Thomas (Rutgers University, USA)
9:00 am - 9:25 am
Fabiana Perocchi (Ludwig Maximilian University of Munich, Germany)
"MCU Stoichiometry and Binding Partners Identified Through a Proteomic Approach"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Kevin Foskett (Perelman School of Medicine, University of Pennsylvania, USA)
"Interorganellar Crosstalk Between the ER and Mitochondria"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
Elisa Greotti (Institute of Neuroscience, National Research Council (CNR), Italy)
"mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo "
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Israel Sekler (Ben-Gurion University of the Negev, Israel)
"Mitochondrial Function Deciphered Through Optogenetics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Jorgina Satrustegui (Universidad Autónoma de Madrid, Spain)
"Calcium Regulation of Mitochondrial Carriers"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Targeting Ca2+ Channels for Drug Discovery: The View from Pharma
Discussion Leader: Colin Taylor (University of Cambridge, United Kingdom)
6:00 pm - 6:25 pm
Klaus Seuwen (Novartis Institutes for Biomedical Research, Switzerland)
"Novel Approaches to Target Calcium-Mobilising Receptors"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Grace Stutzmann (Chicago Medical School, Rosalind Franklin University of Medicine and Science, USA)
"Targeting Ryanodine Receptors as a Therapeutic Strategy for Neurodegenerative Disease and Brain Injury"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Geert Bultynck (KU Leuven, Belgium)
"Reciprocal Sensitivity of Diffuse Large B-Cell Lymphoma Cells to Bcl-2 Inhibitors BIRD-2 Versus Venetoclax"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Srikant Viswanadha (Rhizen Pharmaceuticals SA, Switzerland)
"RP3128: An Oral Calcium Release Activated Calcium (CRAC) Channel Inhibitor for Immune-Inflammatory Disorders"
7:35 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Ca2+ Signals in Inflammatory and Immunological Disease
Discussion Leader: Aldebaran Hofer (Harvard Medical School / VA Boston Health Care System, USA)
9:00 am - 9:25 am
Murali Prakriya (Northwestern University, USA)
"Calcium Signals and Airway Epithelial Cell Activation"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Nicolas Demaurex (University of Geneva, Switzerland)
"Calcium Signalling and Neutrophil Function"
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
Miryam Hortua Triana (Center for Tropical and Emerging Global Diseases, University of Georgia, USA)
"Two Mechanisms of Calcium Entry in Toxoplasma gondii , Each with Specific Roles in Virulence Pathways"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Stefan Feske (New York University School of Medicine, USA)
"Store-Operated Calcium Entry in Autoimmunity"
11:30 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Markus Hoth (Saarland University, Germany)
"Calcium Signatures of T-Cell and NK Cell Cytotoxicity"
12:10 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Late-Breaking Topics / Keynote Session: Mitochondria - Conductors of the Calcium Orchestra
Discussion Leader: Anant Parekh (Oxford University, United Kingdom)
6:00 pm - 6:15 pm
Kozo Hamada (RIKEN, Japan)
"Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography"
6:15 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
Ornella Manfra (University of Oslo, Norway)
"Super-Resolution (dSTORM) Imaging of Calcium Handling Proteins in Cardiomyocytes"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:40 pm
Rosario Rizzuto (University of Padova, Italy)
"Mitochondria: Conductors of the Calcium Orchestra"
7:40 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure