Insights into Molecular Signaling, Cellular Function and Disease

June 6 - 7, 2015

Chairs

and

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, Maine, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Calcium Signalling is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of the 2015 meeting is to highlight the latest developments in Calcium Signalling and to stimulate participants to identify the most relevant questions that need to be answered in the near future. Topics of discussion in scientific sessions include structure and function of calcium signaling molecules and components, and advances in understanding calcium signaling and the associated changes in physiology and disease.

The meeting will feature a keynote presentation by Professor Diane Lipscombe, PhD (Department of Neuroscience, Brown University), as well as a manuscript writing/career development session, presented by Dr. Elizabeth Adler (Executive Editor, Journal of General Physiology) and Lorna MacEachern (Director of Postdoctoral Career Services, Yale University).

Related Meeting

This GRS will be held in conjunction with the "Calcium Signalling" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pm	Keynote Session: The Diversity of Calcium Signaling
	Discussion Leaders: Kamil Alzayady (University of Rochester, USA) and Ivana Kuo (Yale University, USA)
3:45 pm - 4:20 pm	Diane Lipscombe (Brown University, USA) "Neuronal Calcium Channels: From One to Thousands"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm	Dinner
7:30 pm - 9:30 pm	Calcium Entry and Cell Biology
	Discussion Leaders: Sandip Patel (University College London, United Kingdom) and Sona Lakshme Balasubramaniam (University of Delaware, USA)
7:30 pm - 7:45 pm	Jennifer Stancill (Vanderbilt University, USA) "Aberrant Ca²⁺-Signaling Disrupts Islet Morphology and Affects β-cell Identity"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Veronica Granatiero (University of Padua, Italy) "MICU3 Is a Neuron-Specific Enhancer of Mitochondrial Calcium Uptake"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Xuexin Zhang (Pennsylvania State University, College of Medicine, USA) "Complex Roles of STIM1 in the Activation of Store-Independent Orai1/3 Channels"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Claire Whitworth (Newcastle University, United Kingdom) "Phenotype-Specific Store-Operated Calcium Entry in Differentiating Neuroblastoma Cells"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Dhananjay Thakur (University of Texas Health Science Center at Houston, USA) "Coincident Stimulation of Gi/o Proteins and PLC-δ-1 Supports Activation of Receptor Operated TRPC4 Channels"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Monika Jakubowska (Cardiff University School of Biosciences, United Kingdom) "Pathophysiological Ca²⁺ and NO Signaling in Pancreatic Stellate Cells"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Signaling from the Endoplasmic Reticulum
	Discussion Leaders: Sebastian Boie (University of Auckland, New Zealand) and David Yule (University of Rochester, USA)
9:00 am - 9:15 am	Rahul Chandrasekhar (University of Rochester, USA) "Novel Insights into the Regulation of Heteromeric Inositol 1,4,5-Trisphosphate Receptors Using Concatenated Constructs"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	Vera Konieczny (University of Cambridge, United Kingdom) "Segregated IP₃-Sensitive Stores Respond to IP₃ or IP₃ with cAMP in HEK293 Cells"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Forrest Wright (State University of New York, Upstate Medical University, USA) "Erlin2 and RNF170: Major Players in Inositol 1,4,5-Trisphosphate Receptor Degradation and Desensitization by the Ubiquitin-Proteasome Pathway"
9:55 am - 10:00 am	Discussion
	Mentorship Component: Papers and Networking
10:00 am - 10:25 am	Elizabeth Adler (The Journal of General Physiology, USA) "Tips and Tricks from a Journal Editor"
10:25 am - 10:30 am	Discussion
10:30 am - 10:55 am	Lorna MacEachern (McGill University, Canada) "Networking and Next Steps"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session
	Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm	Lunch
1:30 pm - 2:30 pm	Calcium Signaling in Disease and Therapy
	Discussion Leaders: Stine Frandsen (Copenhagen University Hospital, Herlev, Denmark) and Andrew James (The University of Manchester, United Kingdom)
1:30 pm - 1:45 pm	Ram Chandra Paudel (KU Leuven, Belgium) "Non-Canonical Autophagy Induced by Resveratrol Needs Intracellular Ca²⁺ Signaling"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	Galina Schmunk (University of California, Irvine, USA) "Reduced IP₃-Mediated Ca²⁺ Signaling in Autism Spectrum Disorders in the Context of Fragile X and Tuberous Sclerosis Syndromes"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:25 pm	Robert Hooper (Temple University, USA) "Novel PKC-Mediated Control of Orai1 Function in Invasive Melanoma"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period
	Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Conference Links

Conference History Calcium Signalling