| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CANCER PATHWAYS |
| Discussion Leader: D. Dean (Washington University) |
| 7:30 pm - 8:10 pm | E. Fearon (U. Michigan)
"Cadherins and catenins: genetics and epigenetics" |
| 8:10 pm - 8:50 pm | W. Gu (Columbia)
"Regulation of p53-mediated function by acetylation" |
| 8:50 pm - 9:30 pm | M. Roussel (St. Jude)
"Role of cell cycle inhibitor proteins in development and cancer" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENE SILENCING 1 |
| Discussion Leader: R. Weksberg (Hospital for Sick Children, Toronto) |
| 9:00 am - 9:39 am | T. Bestor (Columbia)
"Cytosine methylation and genomic stability" |
| 9:39 am - 10:18 am | R. MacLeod (MethylGene, Inc.)
"Epigenetic regulators as novel cancer targets" |
| 10:18 am | Group Photo and Coffee Break |
| 10:33 am - 11:12 am | A. Feinberg (Johns Hopkins)
"DNA methylation, genomic imprinting and cancer" |
| 11:12 am - 11:51 am | S. Belinsky (Lovelace Research Institute)
"Gene Targets for Aberrant Promoter Hypermethylation: Utility for Cancer Screening" |
| 11:51 am - 12:30 am | K. Ushijima (National Cancer Center Research Institute, Tokyo)
"Gene silencing in breast cancers and its diagnostic application" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHROMATIN AND CANCER 1 |
| Discussion Leader: T. Magnuson (UNC Chapel Hill) |
| 7:30 pm - 8:00 pm | K. Ahmad (Harvard)
"Replacement histone H3 variants mark transcriptionally active sites" |
| 8:00 pm - 8:30 pm | T. Magnuson (UNC Chapel Hill)
"Genome imprinting regulated by a mouse Polycomb group protein" |
| 8:30 pm - 9:00 pm | T. Kouzarides (Wellcome Trust/Cancer Research Institute)
"Histone methylation and transcriptional control" |
| 9:00 pm - 9:30 pm | Y. Shi (Harvard)
Transcriptional repression through coordinated histone modifications mediated by a CtBP co-repressor complex |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | REPAIR AND RECOMBINATION 1 |
| Discussion Leader: W. Bonner (NCI) |
| 9:00 am - 9:39 am | A. Nussenzweig (NCI)
"Role of DNA damage detection and repair in maintaining genomic stability" |
| 9:39 am - 10:18 am | W. Bonner (NCI)
"Histone H2AX and chromatin integrity" |
| 10:18 am | Coffee Break |
| 10:33 am - 11:12 am | M. Thayer (Oregon Health Sciences University)
"Delayed Chromosome Replication Timing, Checkpoint Adaptation and Genomic Instability" |
| 11:12 am - 11:51 am | M. Weitzman (Salk Institute)
"Viral oncoproteins and DNA repair" |
| 11:51 am - 12:30 am | J. Chen (Mayo Clinic, Rochester)
"Regulation of DNA damage signal transduction" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BREAST AND OVARIAN CANCER MECHANISMS |
| Discussion Leader: R. Scully (Harvard) |
| 7:30 pm - 8:00 pm | R. Baer (Columbia)
"Biological functions of the BRCA1/BARD1 heterodimer" |
| 8:00 pm - 8:30 pm | T. Ludwig (Columbia)
"Breast cancer mechanisms in mouse models" |
| 8:30 pm - 9:00 pm | M. Jasin (Memorial Sloan-Kettering)
"Double-strand break repair and tumorigenesis" |
| 9:00 pm - 9:30 pm | T. Taniguchi (Harvard)
"Disruption of the Fanconi anemia/BRCA pathway in cisplatin-sensitive ovarian tumors" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CANCER MARKERS: GENETICS AND EPIGENETICS |
| Discussion Leader: R. Santella (Columbia) |
| 9:00 am - 9:39 am | M. Yu (USC/Norris Cancer Center)
"Gene-environment interactions in cancer risk: prospective studies in Chinese" |
| 9:39 am - 10:18 am | D. Christiani (Harvard)
"Gene-Environment Interactions: The Case of Lung Cancer" |
| 10:18 am | Coffee Break |
| 10:33 am - 11:12 am | C. Ambrosone (Mt. Sinai, New York)
"From genotype to phenotype: considerations for molecular epidemiologic studies" |
| 11:12 am - 11:51 am | R. Lesche (Epigenomics, AG)
"Methylation Profiling to Identify Colon Cancer Markers for Early Detection of Disease" |
| 11:51 am - 12:30 am | R. Santella (Columbia)
"Immunologic measurment of DNA and protein adducts and relationship to cancer risk" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Business Meeting |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHROMATIN AND CANCER 2 |
| Discussion Leader: M. Cleary (Stanford) |
| 7:30 pm - 7.55 pm | P. Pelicci (European Institute of Oncology)
"Chromatin changes in leukemias" |
| 7.55 pm - 8:20 pm | M. Cleary (Stanford)
"Mutations of the epigenetic regulatory machinery in leukemias" |
| 8:20 pm - 8.45 pm | B. Weissman (UNC Chapel Hill)
"Loss of snf5/ini1 activity in human tumors inactivates Rb and p53 tumor suppressor pathways" |
| 8.45 pm - 9:10 pm | D. Dean (Washington University)
"Rb function and chromatin alterations" |
| 9.10 pm - 9.30 pm | G. Filippova (Fred Hutchinson Cancer Research Center)
"CTCF is a tumor suppressor that is essential for early embryonic development" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENE SILENCING 2 |
| Discussion Leader: B. Tycko (Columbia) |
| 9:00 am - 9:39 am | E. Li (Harvard)
"Epigenetic regulation of cell growth" |
| 9:39 am - 10:18 am | M. Oshimura (Tottori University)
"Novel mechanistic studies of genomic imprinting" |
| 10:18 am | Coffee Break |
| 10:33 am - 11:12 am | P. Jones (USC Norris Cancer Center)
"Changing, maintaining and reversing DNA methylation patterns in human cancer" |
| 11:12 am - 11:51 am | W. Reik (Babraham Institute, Cambridge)
"Epigenetic reprogramming in mammalian development" |
| 11:51 am - 12:30 am | F. Urnov (Sangamo Biosciences)
"The chromatin epigenome as a diagnostic and therapeutic target" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 3 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REPAIR AND RECOMBINATION 2 |
| Discussion Leader: M. Jasin (Memorial Sloan-Kettering) |
| 7:30 pm - 8:00 pm | S. Ganesan (Harvard)
"A role for BRCA1 in the maintenance of X inactivation" |
| 8:00 pm - 8:30 pm | B. Michel (Institut National de la Recherche Agronomique)
"Replication fork arrest and the formation of DNA double stand ends" |
| 8:30 pm - 9:00 pm | C. Richardson (Columbia)
"Double strand breaks and genome rearrangements in differentiating cells" |
| 9:00 pm - 9:30 pm | Frank McKeon (Harvard)
"p53 homologs p63 and p73: interactions in stem cells,
neurogenesis, and cancer"
|
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
