| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | GENETICS vs. EPIGENETICS |
| Discussion Leader: Stephen Baylin (John Hopkins University School of Medicine) |
| 7:40 pm - 8:00 pm | Wolf Reik (The Babraham Institute)
"Mechanisms of epigenetic reprogramming in development" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Andrew Feinberg (John Hopkins University School of Medicine)
"The Epigenetics of Cancer Etiology" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Jacqueline Lees (MIT Center for Cancer Research)
"E2F and polycomb in Arf regulation" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:15 pm | Stephen Baylin (Johns Hopkins University School of Medicine)
"Epigenetic Gene Silencing, the Cancer Epigenome, and the Initiation and Progression of Cancer" |
| 9:15 pm - 9:20 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHROMATIN MODIFICATIONS AND TRANSCRIPTION REGULATION |
| Discussion Leader: Shelley Berger (The Wistar Institute) |
| 9:00 am - 9:20 am | Danny Reinberg (Howard Hughes Medical Institute, NYU School of Medicine - Smilow Research Center)
"Chromatin and Its Impact on Gene Expression and Cellular Memory" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Yang Shi (Harvard Medical School)
"Dynamic regulation of histone methylation by demethylases" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Sharon Dent (M.D. Anderson Cancer Center)
"In vivo functions of histone modifying enzymes" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Gunnar Schotta (Institute of Molecular Pathology, Vienna, Austria)
"A chromatin-wide transition to H4K20 mono-methylation impairs genome integrity and programmed DNA rearrangements in the mouse" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break / Group Photo |
| Discussion Leader: Danny Reinberg (Howard Hughes Medical Institute, NYU School of Medicine) |
| 11:00 am - 11:20 am | Shelley Berger (The Wistar Institute)
"Reversible lysine methylation of tumor suppressor p53" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Robert Eisenman (Fred Hutchinson Cancer Research Center)
"Interaction of the Myc Transcription Factor Network with Chromatin" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Paul Knoepfler (University of California Davis, School of Medicine)
"Global epigenetic events in neural stem and tumor cells" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Yan Dai (Boston University)
"SIRT1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | DNA METHYLATION IN CANCER |
| Discussion Leader: Thea Tlsty (University of California, San Francisco) |
| 5:30 pm - 5:50 pm | Peter Jones (University of Southern California)
"Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG Island" |
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:05 pm | Pierre Defossez (Institut Curie, Paris, France)
"CNRS UMR218 Two new human transcription factors that bind methylated DNA have a potential role in cancer" |
| 6:05 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:20 pm | Phillip Shaw (Institute of Pathology, Lausanne, Switzerland)
"The Testis-Specific Factor CTCFL (BORIS) Cooperates with the Protein Methyltransferase PRMT7 in H19 Imprinting Control Region Methylation" |
| 6:20 pm - 6:25 pm | Discussion |
| 6:25 pm - 6:45 pm | Taiping Chen (Novartis Institute for BioMedical Research, Cambridge)
"Role of Lsd1 in ES cells and mouse development" |
| 6:45 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:10 pm | Thea Tlsty (University of California, San Francisco)
"Early Epigenetic and Genetic Events in Carcinogenesis" |
| 7:10 pm - 7:15 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ANEUPLOIDY AND GENOME INSTABILITY |
| Discussion Leader: Tom Misteli (National Cancer Institute, National Institutes of Health) |
| 9:00 am - 9:20 am | Kathrin Muegge (National Cancer Institute)
"Lsh, an epigenetic regulator, crucial for normal heterochromatin structure" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Ralph Scully (Beth Israel Deaconess Medical Center)
"Regulation of sister chromatid recombination by histone H2AX" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Roberta Benetti (Spanish National Cancer Centre - CNIO)
"Epigenetic control of telomeric and subtelomeric regions in mammals" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Anne O'Donnell (Columbia University)
"DNA Demethylation in Breast Cancer" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| Discussion Leader: Kathrin Muegge (National Cancer Institute, NIH) |
| 11:00 am - 11:20 am | Tom Misteli (National Cancer Institute, NIH)
"Spatial genome organization and dynamics in the formation of chromosomal translocations" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Peter Verrijzer (Erasmus University Medical Centre, Rotterdam)
"Chromatin control in development and disease" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Karine Monier (Ecole Normale Superieure de Lyon)
"Dynamics of pericentromeres during the G2 phase" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:15 pm | Vincent Dion (Baylor College of Medicine)
"DNMT1-deficiency promotes triplet repeat expansion in mouse germlines" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | CLINICAL INVESTIGATION |
| Discussion Leader: Robert Brown (Centre for Oncology & Applied Pharmacology Glasgow University) |
| 5:30 pm - 5:50 pm | Art Beaudet (Department of Molecular and Human Genetics, Baylor College of Medicine)
"A mixed epigenetic and genetic and de novo and inherited (MEGDI) model for autism and other disorders" |
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:15 pm | Laurie Jackson-Grusby (Harvard Medical School)
"Functional roles of DNA methylation in cancer" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:40 pm | Jean-Pierre Issa (UTMD Anderson Cancer Center)
"Therapeutic targeting of epigenetic pathways" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 6:55 pm | Toshikazu Ushijima (National Cancer Center Res Institute, Tokyo, Japan)
"Epigenetic Field Defect for Gastric Cancers" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Robert Brown (Centre for Oncology & Applied Pharmacology, Glasgow University)
"Pharmacogenomics and pharmacoepigenomics in ovarian cancer" |
| 7:20 pm - 7:25 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MOUSE TUMOR MODELS |
| Discussion Leader: Hong Wu (UCLA) |
| 9:00 am - 9:20 am | Kristian Helin (Center for Epigenetics, University of Copenhagen)
"Identification and characterization of chromatin modifying enzymes involved in the development of cancer" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Andrew Kung (Dana-Farber Cancer Institute)
"Integrating in vivo imaging endpoints into mouse cancer models" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Chuxia Deng (National Institutes of Health)
"Interplay between BRCA1 and SIRT1 in genetic instability and tumorigenesis" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Ralph Lindemann (Nationales Zentrum fuer Tumorerkrankungen -NCT, Heidelberg)
"Defining the apoptotic pathways underlying HDAC inhibitor-mediated tumor therapy by assessing genotype-response relationships in vivo" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| Discussion Leader: Kristian Helin (Center for Epigenetics, University of Copenhagen) |
| 11:00 am - 11:20 am | Hong Wu (UCLA)
"PTEN, stem cells and tumorigenesis" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Clemens Schmitt (Max-Delbrueck-Center for Molecular Medicine)
"Mechanisms of stress-induced senescence in tumor development and therapy" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Tannishtha Reya (Duke University Medical Center)
"Wnt signaling in Stem Cells and Cancer" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Senta Georgia (Hillblom Islet Research Center, University of California, Los Angeles)
"p27 Regulates the transition of beta-cells from quiescence to proliferation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 6:15 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 6:15 pm - 7:30 pm | SPECIAL SESSION |
| Discussion Leaders: Thomas Jenuwein (co-chair) and En Li (co-chair) |
| 6:15 pm - 6:45 pm | Tony Kouzarides (The Gurdon Institute)
"Function of Chromatin Modifications" |
| 6:45 pm - 6:55 pm | Discussion |
| 6:55 pm - 7:30 pm | Open Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NON-CODING RNAs |
| Discussion Leader: Thomas Gingeras (Biological Sciences, Affymetrix, Inc) |
| 9:00 am - 9:20 am | Denise P. Barlow (Ce-M-M- Research Center for Molecular Medicine of the Austrian Academy of Science)
"Active and repressive chromatin is interspersed without spreading in the Igf2r imprinted gene cluster" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Carlo M. Croce (Ohio State University)
"MicroRNAs and Cancer" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Adele Murrell (University of Cambridge)
"Maintainance of Genomic Imprinting can be disrupted in somatic cells. A model for loss of Imprinting in Cancer" |
| 10:00 am - 10:05 am | Discussion |
| 10:05 am - 10:15 am | Nadine Hornig (Epigenetics and Genome Reprogamming Lab, Institute of Genetics and Biophysics Cnr, Naples, Italy)
"RNAi-mediated knock down of LINEs and SINEs severely affects cell viability" |
| 10:15 am - 10:20 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break
|
| Discussion Leader: Denise P. Barlow (Ce-M-M- Research Center for Molecular Medicine of the Austrian Academy of Science) |
| 11:00 am - 11:20 am | Thomas Gingeras (Biological Sciences, Affymetrix, Inc)
"Genome-wide Transcription Maps Reveal A Modular and Interleaved Organization of Functional Elements and Likely Novel Regulatory Strategies" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Ramin Shiekhattar (Center de Regulacio Genomica, Barcelona, Spain)
"Silencing of the genome through small non-coding RNA" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Ulrich Lehman-Muehlenhoff (Medizinische Hochschule Hannover)
"Epigenetic inactivation of microRNA gene hsa mir-9-1 in human breast cancer" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | RECENT BREAKTHROUGHS |
| Discussion Leader: Benjamin Tycko (Columbia University) |
| 5:30 pm - 5:50 pm | Manel Esteller (Spanish National Cancer Centre, Madrid, Spain)
"The Epigenomes of Cancer Cells" |
| 5:55 pm - 6:10 pm | Raffaela Di Micco (IFOM-IEO-CAMPUS)
"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication" |
| Discussion |
| 6:10 pm - 6:20 pm | Pilar Blancafort (University of North Carolina at Chapel Hill)
"Reactivation of dormant tumor suppressors by artificial transcription factors" |
| 6:20 pm - 6:25 pm | Discussion |
| 6:25 pm - 6:35 pm | Luciano Di Croce (Centre for Genomic Regulation, Barcelona)
"Role of the Polycomb repressive complex 2 in acute promyelocytic leukemia" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:50 pm | Stella Tommasi (City of Hope)
"Genome-wide profiling of CpG island methylation in aging disorders" |
| 6:50 pm - 6:55 pm | Discussion |
| 6:55 pm - 7:15 pm | Benjamin Tycko (Columbia University)
"Genome-wide profiling of allele-specific DNA methylation in normal and cancer tissues" |
| 7:15 pm - 7:20 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
