Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Integrative Cancer Genetics and Epigenetics in Precision Cancer Therapy
Discussion Leader: Hui Shen (Van Andel Institute, United States)
7:40 pm - 8:10 pm
Kathleen Burns (Dana-Farber Cancer Institute, United States)
"Retrotransposon in Cancer: The Marker and the Mutator"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Joseph Costello (UCSF, United States)
"Drivers of Tumor Cell Immortality and Early Clonal Expansions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jonathan Licht (The University of Florida, United States)
"Histone Mutations as Cancer Drivers"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer and Non-Coding Genome
Discussion Leader: Feng Yue (Northwestern University, United States)
9:00 am - 9:25 am
Nada Jabado (mcgill university, Canada)
"Histone Mutations in Disease: From Cancer and Beyond"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Peter Scacheri (Amgen, United States)
"Oncogenic Reactivation of Young L1s is a Hallmark of Colon Cancer"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Hui Shen (Van Andel Institute, United States)
"New Single-Cell Tools to Study Cancer 'Epigenetics'"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Danny Leung (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Epigenomic Dysregulation of Retrotransposons in Human Diseases"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Anna Dysko (Oxford Nanopore Technologies, United Kingdom)
"Simultaneous Characterisation of Somatic Genomic and Epigenomic Mutations in Clinical Research Samples Using a Single Nanopore Sequencing Assay"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Christopher Oakes (The Ohio State University - James Cancer Hospital, United States)
"Wilms’ Tumor 1 Functions as a Tumor Suppressor to Suppress FLT3-STAT Signaling and Epigenetic Remodeling in Acute Myeloid Leukemia"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Zuzana Tothova (Dana-Farber Cancer Institute, United States) and Katherine Chiappinelli (George Washington University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Technologies to Interrogate Cancer Genome, Epigenome and 3D Chromatin
Discussion Leader: Guillaume Bourque (McGill University, Canada)
6:00 pm - 6:25 pm
Chia-Lin Wei (The Jackson Labortory, United States)
"Genomic Technologies for Extrachromosomal Circular DNA (ecDNA) Structure and Function Analyses"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Feng Yue (Northwestern University, United States)
"Extensive Enhancer and Silencer Rewriting in AML."
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Elisa Oricchio (EPFL-ISREC, Switzerland)
"Oncogenic Evolution of Chromatin 3D Structure"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Juanma Vaquerizas (MRC London Institute of Medical Sciences, United Kingdom)
"Alterations in Chromatin Looping and Enhancer Function in Acute Myeloid Leukemia"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transposable Elements and Immune Response
Discussion Leader: Danny Leung (Hong Kong University of Science and Technology, Hong Kong SAR China)
9:00 am - 9:25 am
Katherine Chiappinelli (George Washington University, United States)
"Targeting Transposable Elements to Reverse Immune Evasion in Cancer"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Guillaume Bourque (McGill University, Canada)
"Graph Genomes Reveal Missing Signal in Epigenomic Data"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Zuzana Tothova (Dana-Farber Cancer Institute, United States)
"Transposable Element Activation in Cohesin-Mutant Myeloid Malignancies"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Didier Trono (Ecole Polytechnique Federale de Lausanne, Switzerland)
"KRAB Zinc Finger Proteins Protect Cancer Cells from Transposon-Driven Genotoxic Stress"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Ozgen Deniz (Queen Mary University of London, United Kingdom)
"Gene Regulation by Transposable Elements in Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Michael Keogh (EpiCypher Inc, United States)
"Nucleosome Conformation Dictates the Histone Code"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intratumoral Heterogeneity
Discussion Leader: Yun Nancy Huang (Texas A&M University, United States)
6:00 pm - 6:25 pm
Sarah Aitken (University of Cambridge, UK, United Kingdom)
"Rerunning Tumour Evolution Reveals Germline Influences Cancer Susceptibility"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Bing Ren (University of California, San Diego, United States)
"Dissecting Gene Regulatory Circuits with Single-cell Epigenomics"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Celine Vallot (Institut Curie, France)
"Mechanisms of Cell Plasticity in Breast Cancer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Luca Magnani (Imperial College London, United Kingdom)
"Sleepwalking Through Evolution: A Tale of Dormancy and Hormone-Dependent Breast Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer Systems Biology
Discussion Leader: Sarah Aitken (University of Cambridge, UK, United Kingdom)
9:00 am - 9:25 am
Martin Hirst (University of British Columbia, Canada)
"Heterogeneity in Chromatin States Define a Disease Spectrum in Synovial Sarcoma"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Peter Jones (Van Andel Institute, United States)
"Role of DNMT3A in Cancer"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Han Liang (The University of Texas MD Anderson Cancer Center, United States)
"Fill the Gap Between Cancer Omics Data and Precision Cancer Medicine."
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Piero Carninci (Human Technopole, Italy)
"Global Analysis of Transcriptome and its Interaction with Chromatin in the FANTOM6 Project"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Lyndsay Murrow (Genentech, United States)
"Single-Cell Multiome Profiling from the coopERA trial: a Window into the Response to Endocrine Therapies in Early ER+ Breast Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Hyo Sik Jang (Van Andel Institute, United States)
"VAI-SU2C Epigenetics Dream Team: Synergistic Potential of Epigenetic Therapy and Immunotherapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yolanda Colino Sanguino (Children's Cancer Institute, Australia)
"Targeting Epigenetic Vulnerabilities in H3K27-altered Diffuse Midline Glioma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sriharsa Pradhan (New England Biolabs, Inc, United States)
"Genome Wide Integrative Spatio-Functional Genomics Using Novel Bifunctional Nicking Enzyme Reveals NPM1 as a Transcription Factor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Beyond the Tumor Cells: Microenvironment and Macroenvironment
Discussion Leader: Daniel De Carvalho (Princess Margaret Cancer Centre, Canada)
6:00 pm - 6:25 pm
Yvonne Fondufe-Mittendorf (Van Andel institute, United States)
"3D Chromatin Structure at the Intersection of Toxicology and Disease."
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Cheryl Walker (Baylor College of Medicine, United States)
"Enhancer Reprogramming Drives an Epigenomic Risk Network for Liver Tumorigenesis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Marisa Bartolomei (University of Pennsylvania, United States)
"DNA Methylation Reprogramming in Mammals"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Toshikazu Ushijima (Hoshi University, Japan)
"Epigenetic Field with Epithelial and Stromal Cells Predicts Cancer Risk"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translational Epigenetics: Detection and Therapy
Discussion Leader: Zuzana Tothova (Dana-Farber Cancer Institute, United States)
9:00 am - 9:25 am
Daniel De Carvalho (Princess Margaret Cancer Centre, Canada)
"Epigenetic Therapy and Immunotherapy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Susan Clark (Garvan Institute of Medical Research, Australia)
"Epigenetic Therapy Disrupts the 3D Epigenome"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Stephen Baylin (Johns Hopkins University, United States)
"Some Approaches to Targeting the Cancer Epigenome for Therapy and Biomarkers"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Lixing Yang (University of Chicago, United States)
"Oncogenic Non-coding Genes Activated by Distal Enhancers through Somatic Genome Rearrangements in Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Marah Altabbal (Mohammed bin Rashid University of Medicine and Health Sciences, United Arab Emirates)
"The Unique Transcriptomic Landscape Behind the Aggressiveness of Breast Cancer in Young Women"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yinghui Li (Nanyang Technological University (NTU), Singapore)
"Aberrant Non-canonical NF-kB Signalling Reprograms the Epigenome Landscape to Drive Oncogenic Transcriptomes in Multiple Myeloma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Chongzhi Zang (University of Virginia, United States)
"Clustered Pattern of Transcription Factor Binding Reveals Phase-Separated Transcriptional Condensates at Super-Enhancers"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Tina Keshavarzian (University of Toronto, Princess Margaret Cancer Research, Canada)
"Exploiting Chromatin Variants to Understand Prostate Cancer Oncogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Andrew Farmer (Takara Bio USA, Inc., United States)
"Development of a Complete, End-to-End, Automated Single-Cell System for Biomarker Discovery."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cancer Genome, Epigenome and Epi-Transcriptome Engineering
Discussion Leader: Martin Hirst (University of British Columbia, Canada)
6:00 pm - 6:25 pm
Mathieu Lupien (Princess Margaret Cancer Centre, Canada)
"Engineering at Chromatin Variants to Modulate Self-Renewal in Leukemia"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Yun Nancy Huang (Texas A&M University, United States)
"TET Mediated Epigenetic Regulation in Cancer and Aging"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Jennifer Karlow (Dana-Farber Cancer Institute, United States)
"Defining the Locus-Specific Landscape of Transposon Expression in Cancers"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Shikhar Sharma (Pfizer, United States)
"Targeting KAT6A/KAT6B Dependencies in Breast Cancer with a Novel Selective, Orally Bioavailable KAT6 Inhibitor, CTx-648/PF-9363"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Housheng He (Princess Margaret Cancer Center, University of Toronto, Canada)
"Dual Function of MEN1 in Regulating Repeat Expression and Tumor-Microenvironment Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
