Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Keynote Session
Discussion Leader: URBI ROY (Indian Institute of Science, India)
3:15 pm - 3:35 pm
Luciane Kagohara (Johns Hopkins University, United States)
"Keynote Presentation: Leveraging Spatial-Omics for Cancer Treatment"
3:35 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Daria Ostroverkhova (Queen's University, Canada)
"DNA Polymerase Epsilon Variants Generate Distinct Mutational Landscape in Endometrial Cancer Genomes"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Development and Implementation of "-omics" Technology
Discussion Leader: Yonghao Liang (Washington University in St. Louis, United States)
5:30 pm - 5:40 pm
Oliver Chung (Duke University, United States)
"Targeting Circular DNA Biogenesis in Cancer"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Benjamin Johnson (Van Andel Institute, United States)
"Total RNA Profiling at Single-Cell Resolution"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Alaa Farghli (Cornell University, United States)
"Integrative Single-Nucleus and Spatial Analysis Maps the Tumor Environment of Fibrolamellar Carcinoma"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Austin Gabel (University of Washington, Fred Hutchinson Cancer Center, United States)
"Cancer-Specific Alternative Polyadenylation Shapes Tumor Phenotypes in vivo "
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Md Noor Akhtar (Indian institute of science, India)
"Regulation of Cell Cycle by Stop Codon Readthrough of FEM1B"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Michael Meers (Washington University School of Medicine in St. Louis, United States)
"Multifactorial Profiling of Epigenetic Landscapes at Single-Cell Resolution"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Johann-Christoph Jann (Dana-Farber Cancer Institute, United States)
"The Role of Transposable Elements as Oncogenic Enhancers in Cohesin-Mutant Myeloid Malignancies."
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Dawn Chen (Broad Institute of MIT and Harvard, United States)
"Long-Range Continuous Mutagenesis of Endogenous Genomes"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Technology-Driven Translational Approaches for Cancer Therapy
Discussion Leader: Maria Valeria Freire Chadrina (CHU de Liege, Belgium)
9:00 am - 9:10 am
Chang Jiang (Moffitt Cancer Center, United States)
"Leveraging CRISPR Screening for a Deeper Understanding of Human Malignancy"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Tomas Kanholm (The George Washington University, United States)
"Dynamic Regulation of Transposable Elements During Malignant Transformation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Christian Cerda-Smith (Duke University, United States)
"Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Jingxin Li (UPenn, United States)
"Cellular Memory and Adaptive Resistance in Metastatic Melanoma"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Arianna Baggiolini (Institute of Oncology Research, BIOS+, Switzerland)
"Human Pluripotent Stem Cells-Based Models to Address Oncogenic Competence"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Evelyn Nguyen (Memorial Sloan Kettering Cancer Center, United States)
"Targeting LSD1 Rescues MHC-I Antigen Presentation and Overcomes Resistance to PD-L1 Checkpoint Blockade in Small Cell Lung Cancer"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Ashish Goyal (DKFZ, Germany)
"DNMT and HDAC Inhibition Induces Immunogenic Neoantigens From Human Endogenous Retroviral Element-derived Transcripts"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Lian Narunsky Haziza (The Weizmann institute of Science, Israel)
"The Tumor Mycobiome"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Maximizing Success: Technology Development, Career Trajectory, and Work-Life Balance
Discussion Leader: Brooke Grimaldi (Van Andel Institute, United States)
1:30 pm - 1:40 pm
Simon Pearce (Cancer Research UK Manchester Institute, United Kingdom)
"A cfDNA Methylation Tissue-of-Origin Classifier for Cancer of Unknown Primary"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Maria F Carrera (University of Pennsylvania, United States)
"Differentiation-Focused CRISPR Screens Identify LSD1i-based Combination Therapy Target That Induces Terminal Differentiation in AML"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:30 pm
Panel Discussion
Maximizing Success: Technology Development, Career Trajectory, and Work-Life Balance
Luciane Kagohara (Johns Hopkins University, United States)
Benjamin Johnson (Van Andel Institute, United States)
Michael Meers (Washington University School of Medicine in St. Louis, United States)
Chang Jiang (Moffitt Cancer Center, United States)
Arianna Baggiolini (Institute of Oncology Research, BIOS+, Switzerland)
Lian Narunsky Haziza (The Weizmann institute of Science, Israel)
David Brocks (immunai, Israel)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
