Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Multidisciplinary Approaches to Cancer Nanotechnology
Discussion Leader: Rainer Haag (Freie Universität Berlin, Germany)
7:40 pm - 8:20 pm
Dennis Discher (University of Pennsylvania, USA)
"Macrophage Checkpoint Blockade for Cancer: Nano Approaches"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
David Mooney (Harvard University, USA)
"Building Immunity with Biomaterials"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering Biomaterials for Cancer Nanotechnology
Discussion Leader: Biana Godin (Houston Methodist Research Institute, USA)
9:00 am - 9:40 am
Giuseppe Battaglia (University College London, United Kingdom)
"Multivalency and Multiplexing in Nanomedicine Design"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:10 am
Natalie Artzi (Brigham and Women's Hospital / Harvard Medical School / Massachusetts Institute of Technology, USA)
"Rational and Biologically-Informed Material Design for Cancer Therapy"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Marcelle Machluf (Technion - Israel Institute of Technology, Israel)
"Nano-Ghosts: Charting a New TRAIL for Mesenchymal Stem Cells"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Marianne Ashford (AstraZeneca UK, United Kingdom) and Maria Vicent (Centro de Investigación Príncipe Felipe, Spain)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Nano-Theranostics
Discussion Leader: Marianne Ashford (AstraZeneca UK, United Kingdom)
7:30 pm - 8:00 pm
Avi Schroeder (Technion - Israel Institute of Technology, Israel)
"Barcoded Cancer Nanomedicines and Nanoimmunotherapies Perform Differently in the Primary Tumor and in the Metastasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Daniel Heller (Memorial Sloan Kettering Cancer Center, USA)
"Machine Learning Processes to Develop Targeted Nanomedicines and Diagnostics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Twan Lammers (RWTH Aachen University, Germany)
"Smart Cancer Nanomedicine"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Rational Design of Polymer Therapeutics
Discussion Leader: Avi Schroeder (Technion - Israel Institute of Technology, Israel)
9:00 am - 9:35 am
Rainer Haag (Freie Universität Berlin, Germany)
"Multifunctional Nanosystems for Virus Capture and Tumor Therapy"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
Maria Vicent (Centro de Investigación Príncipe Felipe, Spain)
"Rationally-Designed Polypeptide-Based Combination Therapeutics"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Alexander Kabanov (University of North Carolina at Chapel Hill, USA)
"Super-High Capacity Polymeric Micelles"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Cameron Alexander (University of Nottingham, United Kingdom)
"Responsive Polymers as Probes and Therapeutics for Cancer Applications"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiome as a Target for Cancer Nanotechnology
Discussion Leader: Wenbin Lin (University of Chicago, USA)
7:30 pm - 8:10 pm
James Moon (University of Michigan, USA)
"Nanotechnologies for Combination Cancer Immunotherapy"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Leaf Huang (University of North Carolina at Chapel Hill, USA) and Wantong Song (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China)
"Nanotechnology for Manipulating the Microbiome in Cancer"
9:10 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immuno-Oncology and Nanotechnology
Discussion Leader: Leaf Huang (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:40 am
Helena Florindo (University of Lisbon, Portugal)
"Nano-Vaccine Delivery Overcomes Resistance to Immune Checkpoint Therapy"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:10 am
Jinming Gao (University of Texas Southwestern Medical Center, USA)
"Non-Canonical STING Activation by a Synthetic Polymer for Innate Stimulation"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Wenbin Lin (University of Chicago, USA)
"Using Nanotechnology to Enhance Cancer Immunotherapy"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Clinical Translation of Cancer Nanotechnologies
Discussion Leader: Kostas Kostarelos (University of Manchester, United Kingdom)
7:30 pm - 8:10 pm
Carl Deutsch (Merck KGaA, Darmstadt, Germany)
"Antibody-Drug Conjugates"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Marianne Ashford (AstraZeneca UK, United Kingdom)
"Developing Nanomedicines to Enable Innovative Cancer Medicines"
9:10 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acid Therapeutics
Discussion Leader: Alexander Kabanov (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:40 am
Daniel Siegwart (University of Texas Southwestern Medical Center, USA)
"Transient Gene Silencing Versus Permanent Gene Editing: Opportunities and Limitations for Nanoparticle Delivery of miRNA and CRISPR/Cas Cancer Treatments"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:10 am
Dan Peer (Tel Aviv University, Israel)
"A Universal Platform for RNA Therapeutics"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Luis Brito (Moderna, USA)
"Lipid Nanoparticles to Enable Delivery of mRNA for Oncology"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
Discussion Leader: Darrell Irvine (Massachusetts Institute of Technology, USA)
7:30 pm - 7:40 pm
John Wilson (Vanderbilt University, USA)
"Polymersomes for STING Agonist Delivery"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Manuel Fuentes (Cancer Research Center, University of Salamanca-CSIC, Spain)
"Deciphering Tumoral Biology by Novel Nano-Functional Proteomics Approaches: Novel Therapeutic Targets in Chronic Lymphocytic Leukemia and Leptomeningeal Diseases"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Mingnan Chen (University of Utah, USA)
"What Will Happen When PD-1+ Cells Are Depleted: A Suppression of Autoimmunity, Not Healthy Immunity"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Angelie Rivera-Rodriguez (University of Florida, USA)
"Magnetic Particle Imaging for Quantitative Tracking of Adoptive Cell Transfer in Cancer Immunotherapy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Dali Wang (Northeastern University, USA)
"Polyethylene Glycol Bottlebrush Mediated siRNA Delivery for Cancer Therapy"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Shrey Sindhwani (University of Toronto, Canada)
"How Do Nanoparticles Enter Solid Tumours?"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Qian Yin (Stanford University, USA)
"Activation of Self- and Neoantigen-Specific Tumor Infiltrating T Cells by Polymeric Nanoparticles"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shira Landau (Technion - Israel Institute of Technology, Israel)
"Tissue-Level Mechanosensitivity: Predicting and Controlling the Orientation of 3D Vascular Networks"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure