Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Imaging Cancer with Nanotechnology
Discussion Leader: Darrell Irvine (Massachusetts Institute of Technology, United States)
7:40 pm - 8:20 pm
Ulrich Wiesner (Cornell University, United States)
"Ultrasmall Fluorescent Core-Shell Silica Nanoparticles for Nanomedicine"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Michelle Bradbury (Weill Cornell Medicine, United States)
"Ultrasmall Silica Nanoparticle-Mediated Activation and Reprogramming of the Tumor-Immune Microenvironment to Augment Anti-Tumor Responses"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Interactions of Nanomaterials with the Tumor Microenvironment
Discussion Leader: James Moon (University of Michigan, United States)
9:00 am - 9:40 am
Paula Hammond (Massachusetts Institute of Technology, United States)
"Tuning Nanoparticle Charge and Composition to Control Targeting and Cellular Trafficking"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 11:10 am
Kostas Kostarelos (University of Manchester, United Kingdom & ICN2, Barcelona, Spain, United Kingdom)
"Nanoscale Tools for the Holistic Management of the Brain Tumor Microenvironment"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Ronit Satchi-Fainaro (Tel Aviv University, Israel)
"Sensitizing P-selectin-expressing brain malignancies to immune checkpoint modulators"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Marianne Ashford (AstraZeneca UK, United Kingdom) and Daniel Heller (Memorial Sloan Kettering Cancer Center, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Materials for Cancer Therapy and Diagnostics
Discussion Leader: Ronit Satchi-Fainaro (Tel Aviv University, Israel)
7:30 pm - 8:10 pm
Michael Mitchell (University of Pennsylvania, United States)
"Delivery Technologies for Cancer Immunotherapy"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Juan Vivero-Escoto (University of North Carolina, Charlotte, United States)
"Engineering Multifunctional Silica-based Nanoparticles for Cancer Treatment"
9:10 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nanotechnology in Cancer Immunotherapy
Discussion Leader: Junsang Doh (Seoul National University, South Korea)
9:00 am - 9:40 am
Susan Thomas (George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, United States)
"Immunotherapeutic Drug Delivery to Lymph Nodes Augments Cancer Immunotherapy"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:10 am
John Wilson (Vanderbilt University, United States)
"Targeting Innate Immunity for Cancer Immunotherapy"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Li Tang (EPFL, Switzerland)
"Nanotechnology Enabled Reprogramming of T-cell Infiltration and Metabolism in Tumor for Enhanced Immunotherapy"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nanomedicine Therapeutics
Discussion Leader: Tom Anchordoquy (University of Colorado, United States)
7:30 pm - 8:10 pm
Emily Day (University of Delaware, United States)
"Transforming Cancer Treatment with Engineered Nanomedicines"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Samir Mitragotri (Harvard University, United States)
""Backpacking" Therapeutics on Living Cells for Cancer Therapy"
9:10 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diagnostics, Imaging, and Nanomaterial-Cell Interactions
Discussion Leader: Debra Auguste (Northeastern University, United States)
9:00 am - 9:40 am
Toumy Guettouche (Mercy BioAnalytics, United States)
"Co-Localized Biomarker Detection on the Surface of Tumor-Derived Extracellular Particles for the Diagnosis of Early-Stage Cancer"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:10 am
Christopher Alabi (Cornell University, United States)
"Enabling Targeted Protein Degradation with Peptide-Based Degraders"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Betty Kim (MD Anderson Cancer Center, United States)
"Designing Nanomaterials for Immune Modulation"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Therapy and Gene Editing for Cancer
Discussion Leader: Susan Thomas (George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, United States)
7:30 pm - 8:10 pm
James Dahlman (Georgia Institute of Technology / Emory University School of Medicine, United States)
"Testing Thousands of Nanoparticles in vivo Using DNA Barcodes"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Debra Auguste (Northeastern University, United States)
"Chemical and Mechanical Insights to Advance Targeted Drug Delivery"
9:10 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Novel Nanotechnology Platforms Moving into the Clinic
Discussion Leader: Marianne Ashford (AstraZeneca UK, United Kingdom)
9:00 am - 9:40 am
Geoffrey Lynn (Vaccitech, Plc, United States)
"Self-Assembling Nanoparticles Based on Amphiphilic Peptides as Tunable Platforms for Cancer Immunotherapy"
9:40 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:10 am
Nicole Steinmetz (University of California, San Diego, United States)
"Plant Viruses Against Cancer"
11:10 am - 11:30 am
Discussion
11:30 am - 12:10 pm
Alexander Kros (Leiden University, The Netherlands)
"Membrane Defects as a Novel Tool to Target Cells"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Frontiers in Cancer Nanotechnology
Discussion Leader: Daniel Heller (Memorial Sloan Kettering Cancer Center, United States)
7:30 pm - 7:40 pm
Gal Chen (Technion – Israel Institute of Technology, Israel)
"Developing Artificial Cell Micro-Factories as Next-Generation Therapeutic Platforms"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Liangliang Hao (Boston University (Assistant Professor)/MIT (Visiting Scientist), United States)
"Microenvironment-triggered multimodal precision cancer diagnostics"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Brian Lyons (University of Oxford, United Kingdom)
"Development of a Novel Ultrasound Responsive Immune Stimulating Platform Technology"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Mengying Hu (Weill Cornell Medical College, United States)
"Priming immune-evasive tumor with T cell exosomes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Or Shemesh (The University of Pittsburgh, United States)
"Genetically Encoded Nanoparticles for Cancer Therapy"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Ting-Yu Shih (Boston University, United States)
"Nanoparticle-guided Chimeric Antigen Receptor T Cell Therapy in Solid Tumors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Scott Tilden (University of Colorado Anschutz Medical Campus , United States)
"Exploiting a Type-III Interferon Response to Reduce Off-Target Accumulation."
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Cristina Zavaleta (University of Southern California, United States)
"A New Multiplexed Proteomic Imaging Strategy using Raman Nanoparticles"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure