Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: CAZymes from Terrestrial and Aquatic Ecosystems
Discussion Leader: Bernard Henrissat (CNRS, France)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Michelle O'Malley (University of California, Santa Barbara, USA)
"Mining Microbiomes for Nature's CAZymes"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Nicolas Terrapon (Aix-Marseille University, France)
"Functional Exploration of the CAZy Databank and Beyond: Discovery of New Families and Substrate Specificities"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plant Cell Walls and Implications to Their Bioconversion
Discussion Leader: Breeanna Urbanowicz (University of Georgia, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Paul Dupree (University of Cambridge, United Kingdom)
"The Importance of Precise Substitution Patterns for Interactions of Hemicelluloses with Cellulose Fibrils"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Cécile Hervé (Station Biologique de Roscoff, France)
"Sugars from the Sea: Cell Wall Polysaccharides from Macroalgae"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Taku Demura (Nara Institute of Science and Technology, Japan)
"Functional Analysis of Polygalacturonases During Water-Conducting Cell Formation Required for Plant Adaptation to Land"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Daniel Cosgrove (Pennsylvania State University, USA)
"The Remarkable Wall-Loosening Actions of a Maize β-Expansin"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Greta Reintjes (Agriculture and Agri-Food Canada, Canada)
"Visualizing Polysaccharide Uptake Using Fluorescent Glycan Conjugates and Single Cell Microscopy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Paul Walton (University of York, United Kingdom) and Nicole Koropatkin (University of Michigan Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzyme Action on Intermolecular Linkages and Complex Carbohydrate Structures
Discussion Leader: Leila Lo Leggio (University of Copenhagen, Denmark)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Lisbeth Olsson (Chalmers University of Technology, Sweden)
"Elucidating the Action of Glucuronoyl Esterases: From Model Substrates to Action on Lignin Carbohydrate Complexes"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Jeffrey Gardner (University of Maryland, Baltimore County, USA)
"Systems Biology Approaches to Characterize Bacterial Chitinases: A Microbe-Centric Perspective on the Degradation of Complex Insoluble Substrates"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Harry Brumer (University of British Columbia, Canada)
"Divide and Conquer: Using Subfamily Analysis to Refine Specificity Determination and Prediction in GH16"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Carbohydrate Active Enzyme Cascades from Diverse Habitats
Discussion Leader: Claire Dumon (Institut National de la Recherche Agronomique, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Matthias Hess (University of California, Davis, USA)
"Solving the Puzzle of Anaerobic Biomass Degradation: Metatranscriptomics of Rumen Fungi"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Phillip Pope (Norwegian University of Life Sciences, Norway)
"Where the Wild Things Are: CAZyme Lessons Learnt from Wild and Domestic Herbivores"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Ana Sofia Luis (University of Gothenburg, Sweden / University of Michigan, USA)
"The Critical Roles of Sulfatases and Fucosidases in Mucin Utilization by Bacteroides"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Elizabeth Ficko-Blean (CNRS / Sorbonne University, France)
"Expanding the Notion of Polysaccharide Utilization Loci: Carrageenan Catabolism in Marine Heterotrophic Bacteria"
11:35 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Jan-Hendrik Hehemann (MARUM, University of Bremen / Max Planck Institute for Marine Microbiology, Germany)
"Exploring the Marine Glyco-Carbon Cycle with CAZymes"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Multi-Enzyme Complexes in Nature and by Design
Discussion Leader: Edward Bayer (Weizmann Institute of Science, Israel)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Raul Perez-Jimenez (CIC nanoGUNE, Spain)
"Ancestral Enzymes: Towards Highly Efficient Biomass Conversion"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Steven Smith (Queen's University, Canada)
"Seaweedosome: Engineering of an Efficient Agarose-Degrading Multi-Enzyme Complex"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Yves Briers (Ghent University , Belgium)
"VersaTile: A High-Throughput DNA Assembly Method for the Combinatorial Construction and Evaluation of Cellulosome Components"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Oxidative Enzymes and Their Partners
Discussion Leader: Jean-Guy Berrin (INRA, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Bastien Bissaro (Aix-Marseille University / INRA, France)
"Connecting the Dots Between Oxidoreductases in Lignocellulose Conversion"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Aurore Labourel (Aix-Marseille University, France)
"Discovery of Fungal Copper Proteins Evolutionarily Related to Lytic Polysaccharide Monooxygenases"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Glyn Hemsworth (University of Leeds, United Kingdom)
"Activation of a Bacterial Lytic Polysaccharide Monooxygenase Using a Small C-Type Cytochrome"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
David Cannella (Université Libre de Bruxelles, Belgium)
"Biophysical Studies of Cellulose Oxidation: Effects on Water and Enzyme Interactions with Cellulose Surfaces"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Kaisa Marjamaa (VTT Technical Research Centre of Finland Ltd, Finland)
"Lytic Polysaccharide Monooxygenases in Preparation of Cellulosic Materials"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Carbohydrate-Active Enzymes for New Bio-Based Chemicals and Materials
Discussion Leader: Kiyohiko Igarashi (VTT Technical Research Centre of Finland Ltd, Finland / University of Tokyo, Japan)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Anne Meyer (Technical University of Denmark, Denmark)
"Engineering of Glycosidases for Enzymatic Synthesis of Human Milk Oligosaccharides"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Naoki Sunagawa (The University of Tokyo, Japan)
"New Cellulosic Materials via Cellulose Endo-Transglycosylases and Cellodextrin Phosphorylases"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Peter Ciesielski (National Renewable Energy Laboratory, USA)
"Interplay Between Cellulose Defects, Nanomechanics and Cellulases: New Insights and Implications for Production of Nanocellulose"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Tools for CAZyme Discovery, Design and Development
Discussion Leader: Roman Brunecky (National Renewable Energy Laboratory, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Adrian Tsang (Concordia University, Canada)
"Production Hosts for the Characterization of New Carbohydrate-Active Enzymes"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Heather Mayes (University of Michigan, USA)
"Unbiased Simulations of CAZy Reaction Mechanisms for Enzyme Engineering"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
André Damasio (Institute of Biology, University of Campinas (UNICAMP), Brazil)
"Redesigning N-Glycosylation Sites to Improve CAZyme Efficiency"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Michael Crowley (National Renewable Energy Laboratory, USA)
"Machine Learning in Enzyme and Biomaterial Design"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
Discussion Leaders: Tina Jeoh (University of California, Davis, USA) and Nicole Koropatkin (University of Michigan Medical School, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Jennifer Nill (University of California, Davis, USA)
"The Effect of LPMOs and Endoglucanases on Cellulose Accessibility and Productive Enzyme Binding"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Sabina Leanti La Rosa (Norwegian University of Life Sciences, Norway)
"Roseburia intestinalis : A Primary Degrader of Dietary β-Mannans"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jonathon Briggs (University of British Columbia, Canada)
"Breakdown and Utilization of Arabinogalactan by Bacteroides in the Human Gut"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Rebecca Pollet (University of Michigan Medical School, USA)
"The Role of TonB in Polysaccharide Utilization by the Bacteroidetes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Kristin Low (Agriculture and Agri-Food Canada, Canada)
"Increasing the Digestibilty of Non-Starch Dietary Polysaccharides with CAZymes Bioprospected from the Chicken Intestinal Microbiome"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure