| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Initiation and Maintenance of Arrhythmias |
| Discussion Leader: Yoram Rudy (Case Western Reserve University) |
| Raymond Ideker (University of Alabama)
Important unanswered questions about the mechanisms of fibrillation and defibrillation |
| Natalia Trayanova (Tulane University)
Shock-induced arrhythmogenesis: post-shock filaments and scroll waves |
| Andrew McCulloch (University of California San Diego)
Experimental and computational modeling of ventricular electromechanical interactions |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Organization of VF / Phase Singularities |
| Discussion Leader: J. Jalife (Syracuse University) |
| John Wikswo (Vanderbilt University)
Cardiac phase, in the spatial or phase domains, for identifying reentrant behavior and examining the response of cardiac tissue to electrical stimulation |
| Coffee Break / Photo |
| Richard Gray (University of Alabama)
Is there a formal justification of the cardiac phase variable and using phase singularities to track spiral waves in fibrillation? |
| Bum-Rak Choi (University of Pittsburgh)
Cellular Determinants of VF dynamics |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The role of connexins in the conduction system of the heart |
| Discussion Leader: I. Kodama (Nagoya University) |
| Mark Boyett (University of Leeds)
Pattern of connexin isoforms expressed in the SA node and its relation to function and dysfunction |
| Igor Efimov (Case Western Reserve University)
The role of connexins in the dual-pathway electrophysiology of the AV node |
| G. Morley (NYU Medical Center)
Molecular and functional characterization of murine cardiac conduction |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Role of Repolarization and Restitution Kinetics |
| Discussion Leader: Denis Noble (Oxford University) |
| Robert Gilmour (Cornell University)
Role of electrical restitution in the development of ventricular fibrillation |
| Alan Garfinkel (UCLA)
Role of electrical and chemical instabilities in the genesis and maintenance of fibrillation |
| Coffee Break |
| David Rosenbaum (MetroHealth Campus of Case Western Reserve University)
Mechanisms for generating and maintaining electrophysiological heterogeneities in the heart; role of restitution, memory, cell coupling, and other factors |
| Shien-Fong Lin (UCLA)
Characterization of electrical restitution: approaches and limitations |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Electro-mechanical Alternans |
| Discussion Leader: Alain Karma (Northeastern University) |
| Kenneth Laurita (MetroHealth Campus of Case Western Reserve University)
Heterogeneity of calcium cycling as a mechanism of arrhythmogenic repolarization alternans |
| William Clusin (Stanford University)
Alternans in the ischemic heart |
| Presentation and discussion of Selected Posters:
Discussion Panel: |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Molecularly Engineered Models of Cardiac Disorders |
| Discussion Leader: Barry London (University of Pittsburgh) |
| Glenn Fishman (NYU Medical Center)
Aberrant Gap Junction Expression in the Heart: Implications for Vulnerability to Arrhythmias and Contractile Dysfunction |
| Alex Stewart (University of Pittsburgh)
Dephosphorylation of Connexins Associated with Impaired Conduction and Atrial Arrhythmias |
| Coffee Break |
| Denis Escande (Nantes, France)
Mouse models of cardiac arrhythmia, transgenes can facilitate or limit arrhythmias |
| Gideon Koren (Brigham & Women's Hospital, Harvard Medical School)
Electrical Remodeling and Arrhythmias in Long QT syndrome: Lessons from Genetic Models in Mice |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Patterned Cultured Cells |
| Discussion Leader: André Kléber (University of Bern, Switzerland) |
| André Kléber (University of Bern, Switzerland)
Impulse conduction in synthetic strands of murine myocytes with genetic deletion of connexins |
| Leslie Tung (Johns Hopkins University)
Reentrant Arrhythmias in Cultured Anisotropic Cardiac Cell Monolayers |
| Presentation and discussion of Selected Posters:
Discussion Panel: |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Gender Differences in Vulnerability to Arrhythmias |
| Discussion Leader: Michael Rosen (Columbia University) |
| Milou-Daniel Drici (University of Nice & University of Pittsburgh)
Basis and consequences of gender differences in cardiac depolarization: Estrogens and androgens are defining gender differences in cardiac repolarization, hence arrhythmias with drugs susceptible to prolong the QT |
| Coffee Break |
| Céline Fiset (Montreal Heart Institute, Montreal, Canada)
Gender differences and hormonal regulation of cardiac repolarization |
| Steve Ebert (Georgetown University)
Androgen Regulation of Cardiac Repolarization |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Multi-dimensional mapping techniques |
| Discussion Leader: Guy Salama (University of Pittsburgh) |
| Arkady Pertsov (SUNY Upstate Medical University)
Three-dimensional imaging of electrical propagation in the heart |
| Richard Schuessler (Washington University) |
| Peter Spooner (NIH, Heart and Lung Institute)
Sudden Death, Genes & Arrhythmogenesis: What's Important for the Public's Health? |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
