Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Regeneration/Repair and Arrhythmogenesis: Potential and
Pitfalls |
| Discussion Leader: Michael Rosen (Columbia University, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 8:05 pm | Lior Gepstein (Technion - Israel Institute of Technology, Israel) "Reprogramming Mature Cells: Changing Nature or Habits?" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Nicola Smart (University of Oxford, United Kingdom) "How to Mend a Broken Heart: Make More Muscle" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Jeff Holmes (University of Virginia, USA) "How to Mend a Broken Heart: Make Better Scars" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pacemaking and Conduction |
| Discussion Leader: Toon Van Veen (University Medical Center, Utrecht, The Netherlands) |
9:00 am - 9:20 am | Vincent Christoffels (Academic Medical Center, Amsterdam, The Netherlands) "Gene Regulatory Elements of the Cardiac Conduction System" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Vadim Fedorov (The Ohio State University College of Medicine, USA) "Nodal Conduction Abnormalities Revealed by Dual-Sided Intramural Optical Mapping" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Peter Mohler (The Ohio State University College of Medicine, USA) "TRPM4 and Sinus Node Pacemaking" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Stacey Rentschler (Washington University at St. Louis, USA) "Reprogramming Strategies for Cardiac Conduction: Yes We Can" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Eugenio Cingolani (Cedars Sinai, USA) "Using Heart Cells to Fix Cardiac Conduction: We Can, Too" |
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Atrial Arrhythmias |
| Discussion Leader: Nathalie Virag (Swiss Federal Institute of Technology, Lausanne, Switzerland) |
6:00 pm - 6:10 pm | Farhad Pashakhanloo (Johns Hopkins University, USA) "Novel High-Resolution Image-Based Model of Whole Human Atria with Realistic Subject-Specific Fiber Orientation" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:35 pm | Guy Salama (University of Pittsburgh, USA) "Relaxin Suppresses AF by Differential Effects on Fibrosis, Myocytes, and Conduction Velocity: Mechanisms" |
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Uli Schotten (Maastricht University, The Netherlands) "The Role of Fat and Fibrosis in the Domestication of AF" |
7:10 pm - 7:25 pm | Discussion |
7:25 pm - 7:45 pm | Sanjiv Narayan (Stanford University, USA) "Mechanistic Therapies for Atrial Fibrillation: Are We Nearly There Yet?" |
7:45 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Ventricular Arrhythmias |
| Discussion Leader: Magdi Yacoub (Qatar Cardiovascular Research Center, Qatar) |
9:00 am - 9:20 am | Burkert Pieske (Deutsches Herzzentrum Berlin / Charité Universitätsmedizin Berlin CVK, Germany) "Ca-Related Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Katja Odening (Heart Center Freiburg University, Germany) "LQT: An Electro-Mechanical Disorder" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Bettina Cuneo (University of Colorado School of Medicine, USA) "In Utero Diagnosis of LQT Syndrome by Magnetocardiography: Possibilities and Limitations" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Peter Schwartz (IRCCS Istituto Auxologico Italiano, Italy) "Management of LQT: How to Project from Mouse to Man" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Natalia Trayanova (Johns Hopkins University, USA) "The Virtual Electrophysiology Lab: From Pad to Patient" |
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Unravelling Arrhythmia Mechanisms: One Channel at a Time (or
Two…) |
| Discussion Leader: Jose Jalife (University of Michigan, USA) |
6:00 pm - 6:10 pm | Przemyslaw Radwanski (The Ohio State University, USA) "A Novel Role for Nav1.6 in Arrhythmogenic Diastolic Ca2+ Release: Neuronal Na+ Channels and the Microdomain Na+/ Ca2+" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:35 pm | Antonio Zaza (Università Milano-Bicocca, Italy) "Late
Sodium Current (SCN5A/NaV1.5) in Acute Ischemia: Does It Exist and, If So, Does It
Matter?" |
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Isabelle Deschenes (Case Western Reserve University, USA) "SCN5A: Driving Sick Sinus Syndrome and Early Atrial Fibrillation" |
7:10 pm - 7:25 pm | Discussion |
7:25 pm - 7:45 pm | Connie Bezzina (Academic Medical Center, Amsterdam, The Netherlands) "SCN10A and SCN5A: Conspiracy to Cause Brugada" |
7:45 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanics Matters |
| Discussion Leader: Ursula Ravens (Dresden University of Technology, Germany) |
9:00 am - 9:20 am | Stephane Hatem (INSERM/UPMC, France) "Shear Stress Effects on Voltage-Sensitive Ion Channel Location: Shifting the Goal Posts" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Alex Quinn (Dalhousie University, Canada) "Mechanical Induction of VF: The Concept of a Critical Window in Both Space and Time" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Elisa Konofagou (Columbia University, USA) "Atrio-Ventricular Electromechanical Wave Imaging: What Can We Learn?" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Peter Taggart (University College London, United Kingdom) "Mechanical Modulation of Cardiac Electrophysiology in Patients: So What?" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Sian Harding (Imperial College London, United Kingdom) "SERCA2a Gene Therapy in Heart Failure: Anti-Arrhythmic Effects of Positive Inotropy" |
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | The Nervous Heart |
| Discussion Leader: James Weiss (David Geffen School of Medicine at UCLA, USA) |
6:00 pm - 6:10 pm | Emily Ongstad (Clemson University / Virginia Tech Carillon Research Institute, USA) "A Cx43 CT-Mimetic Peptide Alters Cx43 and Cx43pS368 Heterocellular Interactions in the Injury Border Zone" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:35 pm | Sami Noujaim (Tufts Medical Center, USA) "Pulmonary Vein Plexi and Pacemaker Function" |
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Dominik Linz (University Homburg/Saar, Germany) "Renal Denervation and Ventricular Arrhythmias: New (Causal?) Links" |
7:10 pm - 7:25 pm | Discussion |
7:25 pm - 7:45 pm | Crystal Ripplinger (University of California, Davis, USA) "Neuronal Effects on Cardiac Source-Sink Relations" |
7:45 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Techniques That (Will) Change the Way We Study and Treat
Cardiac Arrhythmia Mechanisms |
| Discussion Leader: Al George (Northwestern University, USA) |
9:00 am - 9:20 am | Paul Blainey (The Broad Institute, USA) "Single Cell Sequencing: Applications, Challenges, Solutions" |
9:20 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Mario Delmar (New York University School of Medicine, USA) "Visual Proteomics Applied to the Cardiac Connexome: Deciphering Arrhythmia Mechanisms" |
9:55 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Jan Huisken (Max Planck Institute (MPI-CBG), Germany) "Light Sheet Microscopy of the Heart: Seeing Is Believing" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Marisa Jaconi (Geneva University, Switzerland) "Human Stem Cell-Based Three-Dimensional Micro-Tissues for Advanced Cardiac Cell Therapies" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Stefanie Dimmeler (Goethe-University Frankfurt, Germany) "Vascular MicroRNAs: From Contributors to Heart Disease to Therapeutic Targets" |
12:10 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | The Surprising Heart: More than Myocytes |
| Discussion Leader: Gail Robertson (University of Wisconsin, Madison, USA) |
6:00 pm - 6:20 pm | Yoram Rudy (Washington University at St. Louis, USA) "Multi-Scale Cardiac Electrophysiology: From Single Ion-Channel Molecular Structure to the Human Heart Rhythm" |
6:20 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Filip Swirski (Massachusetts General Hospital / Harvard Medical School, USA) "Immune Cells and Ventricular Function" |
6:55 pm - 7:10 pm | Discussion |
7:10 pm - 7:30 pm | Thomas Knopfel (Imperial College London, United Kingdom) "Cell-Specific Expression of Voltage-Sensitive Proteins: Illuminating Cell Activity and Heterotypic Interactions" |
7:30 pm - 7:45 pm | Discussion |
7:45 pm - 7:50 pm | Peng-Sheng Chen (Krannert Institute of Cardiology, USA) "The Surprising Heart: Lessons from the 2015 GRC on Cardiac Arrhythmia Mechanisms" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | Closing Remarks |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |