Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Future of Arrhythmia Therapeutic Development
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Fatty Acid Modulators as LQT1 Therapeutics"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Human Organotypic Slices as a Platform for Preclinical Drug Studies"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Suppressing EADs in Single Cells and VT/VF in Isolated Hearts"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Specificity and Variability in Predictive Modeling
9:00 am - 9:20 am
"Experimentally Calibrated Population of Models Predicts and Explains Inter-Subject Variability"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Cell-Specific Models Can Produce More Robust Simulations"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Proarrhythmia Predictions Using Primary Human Cardiomyocytes"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Predicting Proarrhythmia - The CiPA Initiative"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"The Loss of Popeye Domain-Containing Proteins Promote Atrial Arrhythmogenesis in Mice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Phenotypic Switching After Infarction"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Molecular Mechanisms of Arrhythmia in the Brugada and Long QT Syndromes"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Novel Transcription Factors Regulating Cardiac Conduction"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Single-Base Gene Editing Combined with 3D-Super-Resolution Microscopy in hIPSC-CMs to Study SCN5A Mutations Leading to Arrhythmogenic Right Ventricular Cardiomyopathy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Atrial Fibrillation Is a Dystrophinopathy of the Atria"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Patient-Specific Simulations of Atrial Arrhythmia Enable Precision Catheter Ablation"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Modulation of Sodium Channel Voltage Sensing in AF"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Channelopathies and Cardiac Remodeling in Drosophila "
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Ultrasound-Based Mapping of Electromechanical Rotors During Cardiac Fibrillation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"A Novel Mechanism for the Prediction of Gene-Specific Sensitivity to Class-Ib Antiarrhythmic Mexiletine"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechano-Electrical Signaling in Arrhythmia
Session in memory of Max Lab.
7:30 pm - 7:50 pm
"Stretch Effects on Myocytes and Non-Myocytes in the Heart"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Mechanical Communication in Synchronized Beating Cardiomyocytes"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Visualizing Electrical and Mechanical Activity"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Ephaptic Coupling in Cardiac Diseases"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Illuminating Arrhythmia: Optogenetics in Research and Therapy
9:00 am - 9:20 am
"Optical Electrophysiology in Excitable Cells: What In Vitro Measurements Can and Cannot Predict About Arrhythmia"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Massively Parallel All-Optical Electrophysiology"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Novel Optogenetic Methods to Understand and Treat Cardiac Arrhythmia"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Optogenetics for Selective Activation of Cardiac Autonomic Nerves"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Single-Molecule Fluorescence Imaging of fcAMP Association Dynamics Reveal Ligand-Driven Conformational Changes at Binding Domains in Human Pacemaker HCN Channels"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Transcriptional and Translational Mechanisms in Arrhythmia
7:30 pm - 7:50 pm
"Epigenetics and a Role for miRNA in Arrhythmia"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Transcriptional Regulation of Cardiac Depolarization and Repolarization"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Long-Range Transcriptional Control: Connecting GWAS Hits with Biology"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Remodeling Is an Underlying Mechanism of Global Electrical Heterogeneity and Sudden Cardiac Death"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Targets and Macromolecular Complexes in Cardiac Excitability
9:00 am - 9:20 am
"A New Partner of the Nav1.5 Channel in the Dystrophin-Syntrophin Complex: The Unconventional MAGUK Protein CASK"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Regulation of Cardiac Repolarization by Caveolae"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Cardiac Connectomes and Arrhythmia"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
"A Novel Transporter in the Heart and Its Functional Roles"
11:35 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"KCNJ2 as a Novel Mechanism of CPVT"
12:10 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Old Targets, New Diseases and Mendelian Mysteries
7:30 pm - 7:50 pm
"Gating Pore Currents in SCN5A Mutations Linked to Complex Cardiac Arrhythmias and Dilated Cardiomyopathy"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"iPSC Modeling of Cardiac Arrhythmia"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Do Monogenic Arrhythmia Syndromes Exist? Musings on How Genomics Meets Mendel"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure