Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Future of Arrhythmia Therapeutic Development
Discussion Leader: Lori Isom (University of Michigan, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
Peter Larsson (University of Miami, USA)
"Fatty Acid Modulators as LQT1 Therapeutics"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Igor Efimov (George Washington University, USA)
"Human Organotypic Slices as a Platform for Preclinical Drug Studies"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Riccardo Olcese (University of California, Los Angeles, USA)
"Suppressing EADs in Single Cells and VT/VF in Isolated Hearts"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Specificity and Variability in Predictive Modeling
Discussion Leader: James Weiss (University of California, Los Angeles, USA)
9:00 am - 9:20 am
Blanca Rodriguez (University of Oxford, United Kingdom)
"Experimentally Calibrated Population of Models Predicts and Explains Inter-Subject Variability"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
David Christini (Weill Cornell Medicine, USA)
"Cell-Specific Models Can Produce More Robust Simulations"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Najah Abi Gerges (AnaBios Corporation, USA)
"Proarrhythmia Predictions Using Primary Human Cardiomyocytes"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
Jamie Vandenberg (Victor Chang Cardiac Research Institute, Australia)
"Predicting Proarrhythmia - The CiPA Initiative"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Navneet Bhogal (Imperial College London, United Kingdom)
"The Loss of Popeye Domain-Containing Proteins Promote Atrial Arrhythmogenesis in Mice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Gail Robertson (University of Wisconsin-Madison, USA) and Penelope Boyden (Columbia University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Arrhythmia Triggers
Discussion Leader: Penelope Boyden (Columbia University, USA)
7:30 pm - 7:50 pm
Beth Habecker (Oregon Health and Science University, USA)
"Phenotypic Switching After Infarction"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Peter Ruben (Simon Fraser University, Canada)
"Molecular Mechanisms of Arrhythmia in the Brugada and Long QT Syndromes"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
David Park (NYU Langone Medical Center, USA)
"Novel Transcription Factors Regulating Cardiac Conduction"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Esperanza Agullo Pascual (New York University School of Medicine, USA)
"Single-Base Gene Editing Combined with 3D-Super-Resolution Microscopy in hIPSC-CMs to Study SCN5A Mutations Leading to Arrhythmogenic Right Ventricular Cardiomyopathy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Atrial Fibrillation
Discussion Leader: Jose Jalife (University of Michigan, USA)
9:00 am - 9:20 am
Barbara Casadei (John Radcliffe Hospital, University of Oxford, United Kingdom)
"Atrial Fibrillation Is a Dystrophinopathy of the Atria"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
Patrick Boyle (Johns Hopkins University, USA)
"Patient-Specific Simulations of Atrial Arrhythmia Enable Precision Catheter Ablation"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Jonathan Silva (Washington University in St. Louis, USA)
"Modulation of Sodium Channel Voltage Sensing in AF"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
Karen Ocorr (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Channelopathies and Cardiac Remodeling in Drosophila "
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Jan Christoph (Max Planck Society, Germany)
"Ultrasound-Based Mapping of Electromechanical Rotors During Cardiac Fibrillation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Wandi Zhu (Washington University in St. Louis, USA)
"A Novel Mechanism for the Prediction of Gene-Specific Sensitivity to Class-Ib Antiarrhythmic Mexiletine"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechano-Electrical Signaling in Arrhythmia
Session in memory of Max Lab.
Discussion Leaders: Julia Gorelik (Imperial College London, United Kingdom) and Robert Kass (Columbia University, USA)
7:30 pm - 7:50 pm
Peter Kohl (University of Freiburg, Germany)
"Stretch Effects on Myocytes and Non-Myocytes in the Heart"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Shelly Tzlil (Technion - Israel Institute of Technology, Israel)
"Mechanical Communication in Synchronized Beating Cardiomyocytes"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Stefan Luther (Max Planck Institute for Dynamics and Self-Organization, Germany)
"Visualizing Electrical and Mechanical Activity"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Sharon George (George Washington University, USA)
"Ephaptic Coupling in Cardiac Diseases"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Illuminating Arrhythmia: Optogenetics in Research and Therapy
Discussion Leader: Natalia Trayanova (Johns Hopkins University, USA)
9:00 am - 9:20 am
Adam Cohen (Harvard University, USA)
"Optical Electrophysiology in Excitable Cells: What In Vitro Measurements Can and Cannot Predict About Arrhythmia"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
Emilia Entcheva (George Washington University, USA)
"Massively Parallel All-Optical Electrophysiology"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Philipp Sasse (University of Bonn, Germany)
"Novel Optogenetic Methods to Understand and Treat Cardiac Arrhythmia"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
Matthew Kay (George Washington University, USA)
"Optogenetics for Selective Activation of Cardiac Autonomic Nerves"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Marcel Goldschen-Ohm (University of Wisconsin-Madison, USA)
"Single-Molecule Fluorescence Imaging of fcAMP Association Dynamics Reveal Ligand-Driven Conformational Changes at Binding Domains in Human Pacemaker HCN Channels"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Transcriptional and Translational Mechanisms in Arrhythmia
Discussion Leader: Carol Ann Remme (Academic Medical Center, The Netherlands)
7:30 pm - 7:50 pm
Barry London (University of Iowa, USA)
"Epigenetics and a Role for miRNA in Arrhythmia"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Isabelle Deschenes (Case Western Reserve University, USA)
"Transcriptional Regulation of Cardiac Depolarization and Repolarization"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Ivan Moskowitz (University of Chicago, USA)
"Long-Range Transcriptional Control: Connecting GWAS Hits with Biology"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Larisa Tereshchenko (Oregon Health and Science University, USA)
"Molecular Remodeling Is an Underlying Mechanism of Global Electrical Heterogeneity and Sudden Cardiac Death"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Targets and Macromolecular Complexes in Cardiac Excitability
Discussion Leader: Mario Delmar (New York University School of Medicine, USA)
9:00 am - 9:20 am
Elise Balse (Pierre and Marie Curie University / INSERM UMR1166, France)
"A New Partner of the Nav1.5 Channel in the Dystrophin-Syntrophin Complex: The Unconventional MAGUK Protein CASK"
9:20 am - 9:35 am
Discussion
9:35 am - 9:55 am
Timothy Kamp (University of Wisconsin-Madison, USA)
"Regulation of Cardiac Repolarization by Caveolae"
9:55 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Calum Macrae (Harvard Medical School / Brigham and Women's Hospital, USA)
"Cardiac Connectomes and Arrhythmia"
11:00 am - 11:15 am
Discussion
11:15 am - 11:35 am
Nipavan Chiamvimonvat (University of California, Davis, USA)
"A Novel Transporter in the Heart and Its Functional Roles"
11:35 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Lee Eckhardt (University of Wisconsin-Madison, USA)
"KCNJ2 as a Novel Mechanism of CPVT"
12:10 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Old Targets, New Diseases and Mendelian Mysteries
Discussion Leader: Al George (Northwestern University, USA)
7:30 pm - 7:50 pm
Mohamed Chahine (IUSMQ, Laval University, Canada)
"Gating Pore Currents in SCN5A Mutations Linked to Complex Cardiac Arrhythmias and Dilated Cardiomyopathy"
7:50 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Joseph Wu (Stanford Cardiovascular Institute, Stanford University School of Medicine, USA)
"iPSC Modeling of Cardiac Arrhythmia"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Dan Roden (Vanderbilt University Medical Center, USA)
"Do Monogenic Arrhythmia Syndromes Exist? Musings on How Genomics Meets Mendel"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure