Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Concepts in Arrhythmia Susceptibility
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Macrophages in Cardiac Conduction and Arrhythmia"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Autoimmune Cardiac Channelopathy"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Inflammasome Signaling Promotes Atrial Fibrillation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Approaches for Cell and Tissue Imaging
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Three-Dimensional Electron Tomography of Cardiomyocytes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Real-Time Optical Manipulation of Cardiac Conduction in Intact Hearts"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
"3D Reconstructions of Non-Myocytes in Optically Cleared Hearts Reveal Similar Morphology of Fibroblasts and Resident Macrophages "
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Observing Cardiac Dynamics in 4D and 5D with Volumetric Multi-Spectral Optoacoustic Tomography"
11:15 am - 11:30 am
Discussion
11:30 am - 11:50 am
"From Images to Information: Novel Tools for Modeling Experimental Insights from hiPSC and Derived Cells"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Listening to Voltage in the Heart to Disentangle Mechanisms of Arrhythmias"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Cardiac Ion Channel Structure
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Macromolecular Organization of Cardiac Sodium Channels"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Dynamic Structure of the IKs Channel Voltage Sensor Domain"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Relating Ion Channel Structural Dynamics to Physiological Function"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Unraveling the Mechanisms of the Obese Heart: Role for Potassium Channels "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcriptional, Translational and Epigenetic Regulation of Heart Rhythm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Co-Translational Regulation of Cardiac Ion Channels"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Super-Enhancers and Transcriptional Regulation of Cardiac Electrical Activity"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Transcriptome Analysis of an Atrial Tachy-Paced Pig Model Using Bulk and Single Cell RNA-Sequencing"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels"
11:20 am - 11:35 am
Discussion
11:35 am - 11:55 am
"ETV1 Induces Atrial Remodeling and Arrhythmia"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Dietary Saturated Fat Promotes Arrhythmia by Activating NADPH Oxidase 2"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neuromodulation of Heart Rhythm
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Transcriptional and Signal Transduction Underlying Neuromodulation of Heart Rhythm"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Sympathetic Modulation of Cardiac Electrophysiology"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Autonomic Neuromodulation as Anti-Arrhythmic Therapy"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Decrypting Genetic Variants of Unknown Significance
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genome Editing of Human iPS Cells to Investigate Cardiac Ion Channel Variants"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Automated Electrophysiology for Functional Evaluation of KCNQ1 Variants"
10:00 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Deep Mutational Scanning of SCN5A"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
"Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Electrical Heterogeneity in Adult Zebrafish Hearts Under Normal Conditions and During Proarrhythmic Oxidative Stress "
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Optogenetic Modulation of Central and Intracardiac Neural Pathways Controlling Heart Rhythm in Zebrafish in Development, Ageing and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Prediction of Arrhythmia Risk
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Prediction of Drug-Induced Arrhythmia Using Machine Learning"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Computational Approaches to Predict Cardiac Arrhythmia Susceptibility"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Predicting Proarrhythmia Using Cardiomyocytes Derived from iPS Cells"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Novel Single Cell and High-Throughput Phenotypical Platform to Study Atrial Rhythm in hiPSCs"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Approaches to Antiarrhythmic Therapy
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Novel Approaches to Discover Drug Targets for Atrial Fibrillation"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Identifying Atrial Fibrillation Genes and Mechanisms Using a Multi-Model Systems Approach"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Engineered Heart Slice Preparation for Drug Studies and Disease Modeling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Gene Therapy for Atrial Fibrillation"
11:25 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Noninvasive Cardiac Radiation Therapy for Ablation of Ventricular Tachycardia"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"DG-GUI: A Novel Interactive Tool to Analyze Atrial Tachycardia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanistically-Guided Treatment of Arrhythmias
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Drug Repurposing for Long-QT Syndrome"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Short-Term Variability of Repolarization for Prediction and Prevention of Ventricular Arrhythmia"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Fully Implantable Battery-Free Pacemakers for Optoelectric Stimulation of the Rodent Heart"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Virtual-Heart Technology Guides Ablation of Infarct-Related Ventricular Tachycardia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure