Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Concepts in Arrhythmia Susceptibility
Discussion Leader: Elise Balse (Pierre and Marie Curie University / INSERM UMR1166, France)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Matthias Nahrendorf (Massachusetts General Hospital, USA)
"Macrophages in Cardiac Conduction and Arrhythmia"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Mohamed Boutjdir (State University of New York Downstate Medical Center / NYU School of Medicine, USA)
"Autoimmune Cardiac Channelopathy"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Na Li (Baylor College of Medicine, USA)
"Inflammasome Signaling Promotes Atrial Fibrillation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Approaches for Cell and Tissue Imaging
Discussion Leader: Igor Efimov (George Washington University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Eva Rog-Zielinska (University of Freiburg, Germany)
"Three-Dimensional Electron Tomography of Cardiomyocytes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
Leonardo Sacconi (European Laboratory for Non-Linear Spectroscopy, Italy)
"Real-Time Optical Manipulation of Cardiac Conduction in Intact Hearts"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
Marbely Calderón-Fernández (Institute for Experimental Cardiovascular Medicine (IEKM), Germany)
"3D Reconstructions of Non-Myocytes in Optically Cleared Hearts Reveal Similar Morphology of Fibroblasts and Resident Macrophages "
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Daniel Razansky (ETH Zurich, Switzerland)
"Observing Cardiac Dynamics in 4D and 5D with Volumetric Multi-Spectral Optoacoustic Tomography"
11:15 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mary Maleckar (Simula Research Laboratory, Norway)
"From Images to Information: Novel Tools for Modeling Experimental Insights from hiPSC and Derived Cells"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Enaam Chleilat (Institute for Experimental Cardiovascular Medicine, Germany)
"Listening to Voltage in the Heart to Disentangle Mechanisms of Arrhythmias"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Gail Robertson (University of Wisconsin-Madison, USA) and Carol Ann Remme (Academic Medical Center, The Netherlands)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Cardiac Ion Channel Structure
Discussion Leader: Jeanne Nerbonne (Washington University in St. Louis, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Carol Ann Remme (Academic Medical Center, The Netherlands)
"Macromolecular Organization of Cardiac Sodium Channels"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Charles Sanders (Vanderbilt University, USA)
"Dynamic Structure of the IKs Channel Voltage Sensor Domain"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Yoram Rudy (Washington University in St. Louis, USA)
"Relating Ion Channel Structural Dynamics to Physiological Function"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Ademuyiwa Aromolaran (VA Health Care System / SUNY Downstate Medical Center, USA)
"Unraveling the Mechanisms of the Obese Heart: Role for Potassium Channels "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcriptional, Translational and Epigenetic Regulation of Heart Rhythm
Discussion Leader: Karin Sipido (KU Leuven, Belgium)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Gail Robertson (University of Wisconsin-Madison, USA)
"Co-Translational Regulation of Cardiac Ion Channels"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
Vincent Christoffels (Amsterdam UMC, The Netherlands)
"Super-Enhancers and Transcriptional Regulation of Cardiac Electrical Activity"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
Joana Larupa dos Santos (University of Copenhagen, Denmark)
"Transcriptome Analysis of an Atrial Tachy-Paced Pig Model Using Bulk and Single Cell RNA-Sequencing"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stacey Rentschler (Washington University in St. Louis, USA)
"Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels"
11:20 am - 11:35 am
Discussion
11:35 am - 11:55 am
Carolin Rommel (University of Freiburg, Germany)
"ETV1 Induces Atrial Remodeling and Arrhythmia"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
John Morrow (Columbia University, USA)
"Dietary Saturated Fat Promotes Arrhythmia by Activating NADPH Oxidase 2"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neuromodulation of Heart Rhythm
Discussion Leader: Guy Salama (University of Pittsburgh, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
David Paterson (University of Oxford, United Kingdom)
"Transcriptional and Signal Transduction Underlying Neuromodulation of Heart Rhythm"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Crystal Ripplinger (University of California, Davis, USA)
"Sympathetic Modulation of Cardiac Electrophysiology"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Kalyanam Shivkumar (University of California, Los Angeles, USA)
"Autonomic Neuromodulation as Anti-Arrhythmic Therapy"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Annika Winbo (University of Auckland, New Zealand)
"Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Decrypting Genetic Variants of Unknown Significance
Discussion Leader: Elisabeth Lodder (Academic Medical Center, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Bjorn Knollmann (Vanderbilt University School of Medicine, USA)
"Genome Editing of Human iPS Cells to Investigate Cardiac Ion Channel Variants"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
Carlos Vanoye (Northwestern University, USA)
"Automated Electrophysiology for Functional Evaluation of KCNQ1 Variants"
10:00 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
Andrew Glazer (Vanderbilt University Medical Center, USA)
"Deep Mutational Scanning of SCN5A"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
Dorien Schepers (University of Antwerp / Center of Medical Genetics, Belgium)
"Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Thao Nguyen (David Geffen School of Medicine at UCLA, USA)
"Electrical Heterogeneity in Adult Zebrafish Hearts Under Normal Conditions and During Proarrhythmic Oxidative Stress "
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Matthew Stoyek (Dalhousie University, Canada)
"Optogenetic Modulation of Central and Intracardiac Neural Pathways Controlling Heart Rhythm in Zebrafish in Development, Ageing and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Prediction of Arrhythmia Risk
Discussion Leader: Trine Krogh-Madsen (Weill Cornell Medicine, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Eric Sobie (Icahn School of Medicine at Mount Sinai, USA)
"Prediction of Drug-Induced Arrhythmia Using Machine Learning"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Colleen Clancy (University of California, Davis, USA)
"Computational Approaches to Predict Cardiac Arrhythmia Susceptibility"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Milica Radisic (University of Toronto, Canada)
"Predicting Proarrhythmia Using Cardiomyocytes Derived from iPS Cells"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Alexandre Colas (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Novel Single Cell and High-Throughput Phenotypical Platform to Study Atrial Rhythm in hiPSCs"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Approaches to Antiarrhythmic Therapy
Discussion Leader: Andras Varro (University of Szeged, Hungary)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Sridharan Rajamani (Amgen, USA)
"Novel Approaches to Discover Drug Targets for Atrial Fibrillation"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
Karen Ocorr (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Identifying Atrial Fibrillation Genes and Mechanisms Using a Multi-Model Systems Approach"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
Adriana Blazeski (Johns Hopkins University School of Medicine, USA)
"Engineered Heart Slice Preparation for Drug Studies and Disease Modeling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Rishi Arora (Feinberg School of Medicine, Northwestern University, USA)
"Gene Therapy for Atrial Fibrillation"
11:25 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Phillip Cuculich (Washington University in St. Louis, USA)
"Noninvasive Cardiac Radiation Therapy for Ablation of Ventricular Tachycardia"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Enid Van Nieuwenhuyse (Ghent University, Belgium)
"DG-GUI: A Novel Interactive Tool to Analyze Atrial Tachycardia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanistically-Guided Treatment of Arrhythmias
Discussion Leaders: Ursula Ravens (University Heart Center Freiburg - Bad Krozingen / TU Dresden, Germany) and David Christini (Weill Cornell Medicine, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Lia Crotti (University of Milano-Bicocca / Istituto Auxologico Italiano, IRCCS, Italy)
"Drug Repurposing for Long-QT Syndrome"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Marc Vos (University of Utrecht, The Netherlands)
"Short-Term Variability of Repolarization for Prediction and Prevention of Ventricular Arrhythmia"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Rose Yin (The George Washington University, USA)
"Fully Implantable Battery-Free Pacemakers for Optoelectric Stimulation of the Rodent Heart"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Natalia Trayanova (Johns Hopkins University, USA)
"Virtual-Heart Technology Guides Ablation of Infarct-Related Ventricular Tachycardia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure