Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Emerging Concepts in Computational and Experimental Arrhythmia Research
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Experimental Arrhythmia Research: in vivo Bioelectronics"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Emerging Concepts: Experimental Arrhythmia Research"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Emerging Concepts: Computational Arrhythmia Research"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sinoatrial Nodal Arrhythmias
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Signalling Cascades Connecting Pacemaker Cell Mechanisms and Function in the Sinoatrial Node"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Rethinking How Your Heartbeat Starts"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Sinoatrial Nodal Dysfunction in Human Tissue"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Electrical Remodeling of the Sinoatrial Node During Pregnancy"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autonomic Control of the Heart
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Using hiPSC-derived Sympathetic Neuronal and Neurocardiac Cocultures to Look into Neuronal Contributions to Cardiac Arrhythmia"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Role of Neuropeptide Y in Cardiac Arrhythmias"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Afferent and Efferent Parasympathetic Transmission"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Optogenetic Stimulation of Gs Signaling Increases Ventricular Arrhythmia Triggering From the Endocardium and Modulates Arrhythmia Maintenance and Complexity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Arrhythmias of the Young and Old
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Potential Mechanisms of Age Dependence of Atrial Fibrillation"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Computational Modeling Approaches for Multiscale Investigation of Atrial Arrhythmias"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Diagnosis and Treatment of Pediatric Arrhythmias"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Pathophysiology of Calmodulinopathy"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Probing Mechanisms of Cardiac Long QT Syndrome-Associated Epilepsy with Gene-Edited Stem Cell-Derived Cardiomyocytes and Neurons"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A High-Throughput Drug Cardiotoxicity Screening Pipeline That Uses Cell-Specific Action Potential and Voltage Clamp Data"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Methodologies in Computational Model Rigor and Data Frameworking for Arrhythmia Research and Therapy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Investigating Model Reproducibility for Arrhythmia Simulations from Uncertain Clinical Measurements"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Cell to Whole Organ Global Sensitivity Analysis on a Four-Chamber Electromechanics Model"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Deep Mutational Scanning and Functional Assays: How Functional Genomics Can Keep Pace with Genetic Variant Identification"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Sex Modulates the Human Genome Regulatory System in Heart Failure and Aging"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cardiac Imaging in the Electrophysiology Laboratory
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"In Silico Trials in 400 Human Atria Inform Decision for Pharmacological Versus Ablatio Therapy of Atrial Fibrillation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Explainable Machine Learning for Atrial Fibrillation: Identifying Risk Factors and Predicting Post-Ablation Recurrence"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Optical Imaging Enabled Substrate Mapping for Cardiac Ablation Guidance"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Measuring and Modelling Atrial Biomechanics"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Putting Electromechanical Wave Imaging into Practice in the EP Lab"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extrinsic and Intrinsic Arrhythmogenic Pathologies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Heart Promotes Progression of COVID-19 by Inter-Organ Communication"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Inflammatory Cytokines in the Pathogenesis of Cardiovascular Diseases"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"SARS-CoV-2 Spike Protein-Induced Inflammation, Not Viral Infection of Cardiomyocytes, Underlies Proarrhythmia in COVID-19"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Structural and Electrical Remodeling of the Aging Cardiac Pacemaker"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Ionic Underpinnings of Arrhythmogenesis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Calmodulinopathy: A Case of the Sodium Tail Wagging the Calcium Dog"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Voltage-Energized Calcium-Sensitive ATP Production by Mitochondria"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Novel Pathways for Regulation of Cardiac Electrical and Mechanical Function"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Exploring the Mechanisms Underlying Atrial Arrhythmias and Contractile Dysfunction in Heart Failure"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Ultrasound Reconstruction of Cardiomyocyte Contraction Dynamics"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Impact of Effective Refractory Period Personalization on prediction of Atrial Fibrillation Vulnerability"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
High Throughput Analysis and Screening
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Solid-State High-Throughput Screening Microscopy"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"CRISPRi Gene Modulation and High-Throughput All-Optical Cardiac Electrophysiology Using Human iPSC-CMs"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"High-Throughput Dynamic Clamp to Study Cardiac Action Potentials"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure