Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Emerging Concepts in Computational and Experimental Arrhythmia Research
Discussion Leader: Gary Mirams (University of Nottingham, United Kingdom)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Igor Efimov (Northwestern University, Chicago IL, United States)
"Experimental Arrhythmia Research: in vivo Bioelectronics"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Isabelle Deschenes (The Ohio State University, United States)
"Emerging Concepts: Experimental Arrhythmia Research"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Blanca Rodriguez (University of Oxford, United Kingdom)
"Emerging Concepts: Computational Arrhythmia Research"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sinoatrial Nodal Arrhythmias
Discussion Leader: Alex Quinn (Dalhousie University, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Yael Yaniv (Technion-IIT, Israel)
"Signalling Cascades Connecting Pacemaker Cell Mechanisms and Function in the Sinoatrial Node"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
Edward Lakatta (NIH, United States)
"Rethinking How Your Heartbeat Starts"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Vadim Fedorov (The Ohio State University Wexner Medical Center, United States)
"Sinoatrial Nodal Dysfunction in Human Tissue"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
Céline Fiset (Montreal Heart Institute / Université de Montréal, Canada)
"Electrical Remodeling of the Sinoatrial Node During Pregnancy"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Crystal Ripplinger (University of California, Davis, United States) and Jonathan Silva (Washington University in St. Louis, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autonomic Control of the Heart
Discussion Leader: Crystal Ripplinger (University of California, Davis, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Annika Winbo (University of Auckland, New Zealand)
"Using hiPSC-derived Sympathetic Neuronal and Neurocardiac Cocultures to Look into Neuronal Contributions to Cardiac Arrhythmia"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Neil Herring (University of Oxford, United Kingdom)
"Role of Neuropeptide Y in Cardiac Arrhythmias"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Marmar Vaseghi (University of California, Los Angeles, United States)
"Afferent and Efferent Parasympathetic Transmission"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Vanessa Dusend (University of Bonn, Germany)
"Optogenetic Stimulation of Gs Signaling Increases Ventricular Arrhythmia Triggering From the Endocardium and Modulates Arrhythmia Maintenance and Complexity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Arrhythmias of the Young and Old
Discussion Leader: Dobromir Dobrev (University Hospital Essen, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Uli Schotten (University Maastricht, The Netherlands)
"Potential Mechanisms of Age Dependence of Atrial Fibrillation"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
Stefano Morotti (University of California Davis, United States)
"Computational Modeling Approaches for Multiscale Investigation of Atrial Arrhythmias"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Jennifer Silva (Washington University in St Louis, United States)
"Diagnosis and Treatment of Pediatric Arrhythmias"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
Al George (Northwestern University, United States)
"Pathophysiology of Calmodulinopathy"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Francisco Sanchez-Conde (University of Michigan Department of Pharmacology, United States)
"Probing Mechanisms of Cardiac Long QT Syndrome-Associated Epilepsy with Gene-Edited Stem Cell-Derived Cardiomyocytes and Neurons"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Alexander Clark (Cornell University, United States)
"A High-Throughput Drug Cardiotoxicity Screening Pipeline That Uses Cell-Specific Action Potential and Voltage Clamp Data"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Methodologies in Computational Model Rigor and Data Frameworking for Arrhythmia Research and Therapy
Discussion Leader: Mary Maleckar (Simula Research Laboratory, Norway)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Caroline Roney (Queen Mary University of London, United Kingdom)
"Investigating Model Reproducibility for Arrhythmia Simulations from Uncertain Clinical Measurements"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Marina Strocchi (King's College London, United Kingdom)
"Cell to Whole Organ Global Sensitivity Analysis on a Four-Chamber Electromechanics Model"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Lee Eckhardt (University of Wisconsin - Madison, United States)
"Deep Mutational Scanning and Functional Assays: How Functional Genomics Can Keep Pace with Genetic Variant Identification"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Anna Gams (The George Washington University, United States)
"Sex Modulates the Human Genome Regulatory System in Heart Failure and Aging"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cardiac Imaging in the Electrophysiology Laboratory
Discussion Leader: Patrick Boyle (University of Washington, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Albert Dasí (University of Oxford, United Kingdom)
"In Silico Trials in 400 Human Atria Inform Decision for Pharmacological Versus Ablatio Therapy of Atrial Fibrillation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Savannah Bifulco (University of Washington, United States)
"Explainable Machine Learning for Atrial Fibrillation: Identifying Risk Factors and Predicting Post-Ablation Recurrence"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Christine Hendon (Columbia University, United States)
"Optical Imaging Enabled Substrate Mapping for Cardiac Ablation Guidance"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Steven Niederer (King's College London, United Kingdom)
"Measuring and Modelling Atrial Biomechanics"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
Elaine Wan (Columbia University, United States)
"Putting Electromechanical Wave Imaging into Practice in the EP Lab"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extrinsic and Intrinsic Arrhythmogenic Pathologies
Discussion Leader: Enaam Chleilat (Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Johannes Backs (Heidelberg University, Germany)
"The Heart Promotes Progression of COVID-19 by Inter-Organ Communication"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Sridharan Rajamani (Janssen Pharmaceutical Companies of Johnson & Johnson, United States)
"Inflammatory Cytokines in the Pathogenesis of Cardiovascular Diseases"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Rengasayee Veeraraghavan (The Ohio State University, United States)
"SARS-CoV-2 Spike Protein-Induced Inflammation, Not Viral Infection of Cardiomyocytes, Underlies Proarrhythmia in COVID-19"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Claudia Moreno (University of Washington, United States)
"Structural and Electrical Remodeling of the Aging Cardiac Pacemaker"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Ionic Underpinnings of Arrhythmogenesis
Discussion Leader: Trine Krogh-Madsen (Weill Cornell Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Przemyslaw Radwanski (The Ohio State University, United States)
"Calmodulinopathy: A Case of the Sodium Tail Wagging the Calcium Dog"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
W. Jonathan Lederer (University of Maryland School of Medicine, United States)
"Voltage-Energized Calcium-Sensitive ATP Production by Mitochondria"
10:00 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Thomas Hund (The Ohio State University, United States)
"Novel Pathways for Regulation of Cardiac Electrical and Mechanical Function"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
Katharine Dibb (University of Manchester, United Kingdom)
"Exploring the Mechanisms Underlying Atrial Arrhythmias and Contractile Dysfunction in Heart Failure"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Joachim Greiner (IEKM Freiburg, Germany)
"Ultrasound Reconstruction of Cardiomyocyte Contraction Dynamics"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Patricia Martínez (Karlsruhe Institute of Technology, Germany)
"Impact of Effective Refractory Period Personalization on prediction of Atrial Fibrillation Vulnerability"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
High Throughput Analysis and Screening
Discussion Leader: Edward Vigmond (University of Bordeaux, France)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Gil Bub (McGill University, Canada)
"Solid-State High-Throughput Screening Microscopy"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Emilia Entcheva (George Washington University, United States)
"CRISPRi Gene Modulation and High-Throughput All-Optical Cardiac Electrophysiology Using Human iPSC-CMs"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Teun De Boer (UMC Utrecht, The Netherlands)
"High-Throughput Dynamic Clamp to Study Cardiac Action Potentials"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure