Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Building an Academic Career
Discussion Leaders: Nicole De Jesus (Stanford University, USA) and Emily Ongstad (MedImmune, USA)
3:45 pm - 4:15 pm
Colleen Clancy (University of California, Davis, USA)
"Building an Academic Career from Post-Doc to Dean's Office in 20 Easy Steps"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Conduction, Pacemaking, and Arrhythmias
Discussion Leaders: Mathilde Rivaud (University Medical Center Utrecht, The Netherlands) and Sharon George (George Washington University, USA)
7:30 pm - 7:40 pm
Drew Nassal (Case Western Reserve University, USA)
"KChIP2 Is a Key Transcriptional Regulator of Cardiac Excitability"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
David Jones (University of Wisconsin-Madison, USA)
"Targeting Intracellular hERG Domains as a Potential Therapeutic Approach"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Eilidh MacDonald (Dalhousie University, Canada)
"Stretch Effects on Pacemaker Activity in Zebrafish"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Axel Loewe (Karlsruhe Institute of Technology, Germany)
"Influence of Electrolyte Concentration Changes on Sinus Node Function - A New Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Nele Vandersickel (Ghent University, Belgium)
"Different Mechanisms of Torsade de Pointes Arrhythmias in the Drug-Induced Chronic AV Block Dog"
8:40 pm - 8:45 pm
Discussion
Modeling in Disease and Drug Development
8:45 pm - 8:55 pm
Sara Dutta (Food and Drug Administration, USA)
"Optimization of an In Silico Cardiac Cell Model for Proarrhythmia Risk Assessment Using hERG-Drug Binding Kinetics and Multi-Channel Pharmacology"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Michael Liu (University of California, Los Angeles, USA)
"T-Wave Alternans and Lability in the Initiation of Ventricular Arrhythmias Caused by QT Prolongation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Anna Muszkiewicz (University of Oxford, United Kingdom)
"Whole Atria Mechanisms of Inducibility and Persistence of Atrial Fibrillation by Depletion of nNOS in Human"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Novel Approaches in
Arrhythmia Diagnosis and Treatment
Discussion Leader: Francis Ortega (Weill Cornell Medical College, USA)
9:00 am - 9:10 am
Tobias Bruegmann (University of Bonn, Germany)
"Optogenetic Termination of Atrial Fibrillation in the Mouse Heart"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Monique Windley (The Victor Chang Cardiac Research Institute, Australia)
"Investigating the Temperature Dependency of hERG Drug Block Kinetics and Potency: Implications for High Throughput Screening Assays and In Silico Proarrhythmic Risk Prediction"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Jan Christoph (Max Planck Society, Germany)
"Ultrasound-Based Mapping of Electromechanical Rotors During Cardiac Fibrillation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Wandi Zhu (Washington University in St. Louis, USA)
"A Novel Mechanism for the Prediction of Gene-Specific Sensitivity to Class-Ib Antiarrhythmic Mexiletine"
9:55 am - 10:00 am
Discussion
Mentorship Component: Career Panels
10:00 am - 10:30 am
Panel Discussion
Early Career Development
Peng-Sheng Chen (Indiana University School of Medicine, USA)
Eleonora Grandi (University of California, Davis, USA)
Colleen Clancy (University of California, Davis, USA)
10:30 am - 11:00 am
Panel Discussion
Non-Academic Careers
David Lathrop (National Heart, Lung, and Blood Institute, NIH, USA)
Najah Abi Gerges (AnaBios Corporation, USA)
Jiansong Sheng (U.S. Food and Drug Administration, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Cardiac Innervation
Discussion Leader: Colin Peters (Simon Fraser University, Canada)
1:30 pm - 1:40 pm
Stephanie Anderson (University of Glasgow, United Kingdom)
"Differential Chronotropic and Inotropic Effects of Left and Right Stellate Ganglion Stimulation in the Innervated Rabbit Heart"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Jakub Tomek (University of Oxford, United Kingdom)
"An Anti-Arrhythmic Potential of Infarct Border Zone Sympathetic Innervation via Alternans Attenuation"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Matthew Stoyek (Dalhousie University, Canada)
"Regulation of Pacemaker Function by the Intracardiac Cardiac Nervous System in Zebrafish"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes