Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Novel Insights into Anti-Arrhythmic Drugs
Discussion Leader: Jaclyn Brennan (The George Washington University, USA)
3:15 pm - 3:25 pm
Adriana Blazeski (Johns Hopkins University School of Medicine, USA)
"Engineered Heart Slice Preparation for Drug Studies and Disease Modeling"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
Hector Martinez-Navarro (University of Oxford, United Kingdom)
"Human In Silico Investigations into Therapeutic Strategies in Acute Myocardial Ischemia"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Zhinuo Wang (University of Oxford, United Kingdom)
"Electrophysiological Response of HCM Myocardium to Disopyramide"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Scientific Rigor and Reproducility / Mapping, Mechanism, Modelling and Medicine
Discussion Leader: Jan Christoph (University Medical Center Göttingen, Germany)
5:30 pm - 6:00 pm
Al George (Northwestern University, USA)
"Scientific Rigor and Reproducility"
6:00 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Enaam Chleilat (Institute for Experimental Cardiovascular Medicine, Germany)
"Listening to Voltage in the Heart to Disentangle Mechanisms of Arrhythmias"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Matthijs Cluitmans (Amsterdam UMC / Philips Research, The Netherlands)
"Steepness of Repolarization Gradients Is Associated with Increased Susceptibility for Trigger-Induced Arrhythmias in Intact Hearts with Drug-Induced Repolarization Dispersion"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Enid Van Nieuwenhuyse (Ghent University, Belgium)
"DG-GUI: A Novel Interactive Tool to Analyze Atrial Tachycardia"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Brian Hansen (The Ohio State University, USA)
"Reentrant Atrial Fibrillation Drivers Identified by Sub-Surface Near-Infrared Optical Mapping May Be Misinterpreted as Multi Breakthroughs by Epicardial Multi-Electrode Arrays"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Caroline Roney (King's College London, United Kingdom)
"Probabilistic Wavefront Analysis of Panoramic Mapping Data Demonstrates Preferential Pathways of Atrial Fibrillation and Predicts Pulmonary Vein Isolation Outcome"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Ion Channel Function and Regulation / Mentorship Component: How to Build Your Own Lab
Discussion Leader: Vincent Portero (Academic Medical Center, University of Amsterdam, The Netherlands)
9:00 am - 9:10 am
Kathryn Mangold (Washington University in St. Louis, USA)
"Enumerating Viable N-State Markov Models of Sodium Channel Dynamics "
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Mohammad-Reza Ghovanloo (Simon Fraser University, Canada)
"Biophysical Characterization of a Novel CPVT-Causing SCN5A Mutation: T1857I"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Ilse van Herck (Simula Research Laboratory, Norway)
"In Silico Model Development of SK Channel Gating, Temperature Dependence and Calcium Sensitivity"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Gerard Marchal (Amsterdam UMC / Academic Medical Center, The Netherlands)
"Targeting the Microtubule Plus-End Tracking EB1-CLASP2 Protein Complex Modulates Nav1.5 Specifically at the Intercalated Disc"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
How to Build Your Own Lab
Patrick Boyle (University of Washington, USA)
Jordi Heijman (Maastricht University, The Netherlands)
Ursula Ravens (University Heart Center Freiburg - Bad Krozingen / TU Dresden, Germany)
Crystal Ripplinger (University of California, Davis, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mechano-Electrical Coupling in the Heart
Discussion Leader: Nele Vandersickel (Ghent University, Belgium)
1:30 pm - 1:40 pm
Ramona Emig (University Heart Center Freiburg - Bad Krozingen, Germany)
"Effects of Dynamic Changes in the Mechanical Environment on Fibroblast-Cardiomyocyte Mechano-Electric Coupling"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Viviane Timmermann (Simula Research Laboratory, Norway)
"A One Dimensional Computational Study of Mechano-Electric Feedback and Arrhythmogenic Current Generation"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Koen Scholman (Amsterdam UMC, University of Amsterdam, The Netherlands)
"Disparity Between Calcium Transient Duration and Action Potential Duration in the Rabbit Right Ventricular Outflow Tract Myocardium"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
D. Ryan King (Fralin Biomedical Research Institute at VTC, USA)
"Perfusate Composition Modulates Cardiac Contractile Properties Before, During and Following an Ischemic Insult"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes