Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Molecular and Cellular Underpinnings of Cardiac Electrophysiology
Discussion Leader: Bert Vandendriessche (Cardiogenetics group - Center of Medical Genetics, University of Antwerp, Belgium, Belgium)
3:45 pm - 3:55 pm
Ahmed Ramadan (Dalhousie University, Canada)
"Optogenetic Suppression of Drug-induced Early Afterdepolarisations in the Zebrafish Heart"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Jaël Copier (Amsterdam UMC, The Netherlands)
"Bradycardia in a Long QT Type 2 Family: Coinciding KCNH2 and HCN4 Variants"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Chandra Prajapati (Tampere University, Finland)
"The Junctophilin-2 Mutation (Thr161Lys) Associated with Hypertrophic Cardiomyopathy using Patient-specific iPS Cardiomyocytes Demonstrate Impaired Energetics and Increased Arrhythmogenicity"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural and Functional Proarrhythmic Substrates
Discussion Leaders: Arthur Bezerra (Ghent University, Belgium)
7:30 pm - 7:40 pm
José Romero Sepúlveda (McGill University, Canada)
"Structure-Mediated Arrhythmogenesis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Louisa Mezache (The Ohio State University, United States)
"Targeting the Vascular Endothelial Barrier to Prevent Nanoscale Cardiac Remodeling: A Novel Strategy to Prevent Atrial Fibrillation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Joachim Greiner (IEKM Freiburg, Germany)
"Ultrastructural Reconstruction of Cardiomyocyte Contraction Dynamics"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Brianna Cathey (Texas A&M School of Engineering Medicine, United States)
"Correlation Analysis Between Heart Rate Variability and Heart Rate Fragmentation in Williams-Beuren Syndrome Subjects Reveals Markers of Non-Autonomic Modulators of Sino-Atrial Node (SAN) Function"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Peter Kohl (University of Freiburg, Germany)
"Praise of Failure"
9:15 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Antiarrhythmic Translational Strategies from Neuromodulation, Ablation, the Role of Non-myocytes and Post-infarction Repair
Discussion Leader: Patricia Martínez (Karlsruhe Institute of Technology, Germany)
9:00 am - 9:10 am
Peter Hanna (UCLA, United States)
"Cardiac Disease Alters Regional Noradrenergic and Cholinergic Innervation of the Human Heart"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Ana Simon Chica (Spanish National Center for Cardiovascular Research (CNIC), Spain)
"On the Role of Non-myocytes in Persistent Atrial Fibrillation Maintenance"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Leto Riebel (University of Oxford, United Kingdom)
"Using Modelling and Simulation to Investigate the Safety of Stem Cell- Derived Cardiomyocyte Delivery in the Infarcted Human Ventricles"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Savannah Bifulco (University of Washington, United States)
"Explainable Machine Learning for Atrial Fibrillation: Identifying Risk Factors and Predicting Post-Ablation Recurrence"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Career Panel: Mind the Gap - Lessons Along the Way
Mark Levin (National Institutes of Health, United States)
Sharon George (Northwestern University, United States)
Kevin McElhanon (Pfizer, United States)
Jaclyn Brennan-McLean (AAAS S&T Policy Fellowship Program, United States)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Extrinsic Factors and Mechanisms Contributing to Cardiac Arrhythmogenesis
Discussion Leader: Vladimír Sobota (IHU Liryc, Electrophysiology and Heart Modeling Institute, Foundation Bordeaux Université, France)
1:30 pm - 1:40 pm
Jessica Caldwell (University of California Davis, United States)
"Whole-Heart Multi-Parametric Optical Imaging Reveals Sex-Dependent Heterogeneity in cAMP Signaling and Repolarization Kinetics"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Anna Gams (The George Washington University, United States)
"Sex Modulates the Human Genome Regulatory System in Heart Failure and Aging"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Alexander Clark (Cornell University, United States)
"A High-Throughput Drug Cardiotoxicity Screening Pipeline That Uses Cell-Specific Action Potential and Voltage Clamp Data"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
An Duong (University Of Ottawa Heart Institute, Canada)
"Growth Differentiation Factor 3 Protects Mice from LPS-induced QT Prolongation"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes