| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:00 pm | Welcome and Introduction to the GRC |
| 7:30 pm - 9:30 pm | MECHANISMS OF HYPERTROPHY AND FAILURE |
| Discussion Leader: Judith Gwathmey (Boston University) |
| 7:30 pm - 7:45 pm | "Overview" Judith Gwathmey (Boston University) |
| 7:45 pm - 8:15 pm | Peter Buttrick (University of Illinois at Chicago)
"PKC signaling and cardiac adaptation" |
| 8:15 pm - 8:30 pm | Speaker chosen from abstracts |
| 8:30 pm - 9:00 pm | Gerald Dorn (University of Cincinnati)
"Molecular predestination 1 : Cardiomyocyte death from growth" |
| 9:00 pm - 9:30 pm | Jeff Molkentin (Cincinnati Children's Hospital Research Foundation)
"Molecular predestination 2: Cardiomyocyte health from growth |
| 9:30 pm | General Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENOMICS, PROTEOMICS, AND PHENOTYPING |
| Discussion Leader: Ken Philipson (UCLA) |
| 9:00 am - 9:30 am | Pei Pei Ping (University of Louisville)
"Characterization of functional sub-proteomes in the heart: Linking cellular mechanisms to phenotypes". |
| 9:30 am- 10:00 am | |
| 10:00 am - 10:15am | Speaker chosen from abstracts |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:00 am | Speaker chosen from abstracts |
| 11:00 am - 11:30 am | Litsa Kranias (University of Cincinnati)
"Proteomics: Novel insights into cardiac function" |
| 11:30 am - Noon | Jennie Van Eyk (Queen's University)
"Unraveling heart failure through proteomics" |
| Noon - 12:15 pm | General Discussion |
| 12:15 pm | Conference Photograph |
| 12:30 pm - 1:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | POSTER SESSION I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RESCUE OF THE FAILING HEART |
| Discussion Leader: Henk ter Keurs (Calgary University) |
| 7:30 pm - 8:00 pm | Roger Hajjar (Harvard University)
"Mechanisms for rescue of the failing Heart" |
| 8:00 pm - 8:15 pm | Speaker chosen from abstracts |
| 8:15 pm - 8:45 pm | Masao Endoh (Yamagata University)
"Inotropic agents" |
| 8:45 pm - 9:00 pm | Speaker chosen from abstracts |
| 9:00 pm - 9:30 pm | Eduardo Marban (Johns Hopkins University)
"The next best thing" |
| 9:30 pm | General Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METABOLISM AND GENE EXPRESSION |
| Discussion Leader: Doug Lewandowski (Univ of Illinois at Chicago) |
| 9:00 am - 9:30 am | Heinrich Taegtmeyer (University of Texas Houston)
"Metabolic adaptation through gene expression" |
| 9:30 am - 10:00 am | Raymond Russell (Yale University)
"Adaptations of glucose uptake by the ischemic Heart" |
| 10:00 am - 10:15 am | Speaker chosen from abstracts |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:00 am | Speaker chosen from abstracts |
| 11:00 am - 11:30 am | Dan Kelly (Washington University)
"Peroxisome proliferator-activated receptor and transcriptional Control of Cardiac Fatty Acid Oxidation" |
| 11:30 am - Noon | Jeanie McMillin (University of Texas Houston)
"Regulation of rat carnitine palmitoyltransferase I gene expression: Potential sites of COUP TF II interaction". |
| Noon - 12:30 PM | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | POSTER SESSION II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SIGNALING: LOCALIZATION AND SCAFFOLDING |
| Discussion Leader: Larry Jones (Indiana University) |
| 7:30 pm - 8:00 pm | Susan Steinberg (Columbia University)
"Compartmentation of signaling pathways in cardiac myocytes" |
| 8:00 pm - 8:15 pm | Speaker chosen from abstracts |
| 8:15 pm - 8:45 pm | Meredith Bond (Cleveland Clinic Foundation)
"AKAPs and cellular signaling" |
| 8:45 pm - 9:00 pm | Speaker chosen from abstracts |
| 9:00 pm - 9:30 pm | Daria Mochly-Rosen (Stanford University)
"PKC and heart functions" |
| 9:30 pm | General Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | INTEGRATIVE BIOLOGY: MATHEMATICAL MODELING |
| Discussion Leader: Donald Bers (Loyola University) |
| 9:00 am - 9:30 am | Thomas Shannon (Loyola University)
"Modeling of EC coupling" |
| 9:30 am - 10:00 am | Kenneth Campbell (Washington State University)
"Dynamic LV elastance: Myofilament contractile origins" |
| 10:00 am - 10:15 am | Speaker chosen from abstracts |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:00 am | Speaker chosen from abstracts |
| 11:00 am - 11:30 am | J. Jeremy Rice (IBM T J Watson Research Center)
"Modeling myofilament force and sensitivity to Ca2+ " |
| 11:30 am - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | POSTER SESSION III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MYOFILAMENTS AND MYOPATHIES |
| Discussion Leader: John Solaro (University of Illinois at Chicago) |
| 7:30 pm - 8:00 pm | James Potter (University of Miami)
"FHC Tn Mutations: Functional consequences and mechanisms" |
| 8:00 pm - 8:15 pm | Speaker chosen from abstracts |
| 8:15 pm - 8:45 pm | Larry Tobacman (University of Iowa)
"Mechanisms of thin filament activation" |
| 8:45 pm - 9:00 pm | Speaker chosen from abstracts |
| 9:00 pm - 9:30 pm | Pieter deTombe (University of Illinois at Chicago)
"Frank-Starling law of the heart: Role of inter-filament spacing" |
| 9:30 pm | General Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENDER RELATED DIFFERENCES |
| Discussion Leader: Ed Lakatta (NIA/NIH) |
| 9:00 am - 9:30 am | Leslie Leinwand (University of Colorado)
"Gender differences in cardiac function and disease" |
| 9:30 am - 10:00 am | Michael Rosen (Columbia University)
"Determinants of gender-related differences in the ECG" |
| 10:00 am - 10:15 am | Speaker chosen from abstracts |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:00 am | Speaker chosen from abstracts |
| 11:00 am - 11:30 am | Judith Brouillette |
| 11:30 am- noon | Christian Grohe (RheinÃsche Friedrich Wilhelms Universität)
"Sex hormones and signaling in cardiac disease" |
| noon - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | DISCUSSION OF CURRENT QUESTIONS |
| Discussion Leader: Steve Houser (Temple University) |
| 4:00 pm - 5:00 pm | Question: "Are alterations in the properties of the cardiac Ca release channel centrally involved in the deranged Ca transient in heart failure?" |
| Discussants: Andrew Marks (Columbia University)
David Eisner (Manchester University) |
| 5:00 pm - 6:00 pm | Question: "Is abnormal SR Ca release in CHF caused by EC coupling or SR transport defects?" |
| Discussants: Brian O'Rourke (Johns Hopkins University)
Jon Lederer (University of Maryland) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BUSINESS MEETING AND KEYNOTE LECTURE |
| Discussion Leaders: John Solaro (University of Illinois at Chicago)
Steve Houser (Temple University) |
| 7:30 pm - 8:00 pm | Business Meeting |
| 8:00 pm - 9:00 pm | Jeff Robbins (Cincinnati Children's Hospital Research Foundation)
"How not to fail at studying failure: The next 5 years" |
| 9:00 pm | General Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
