| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The Dichotomous Role of Ca2+ in Contractility And Signaling |
| Discussion Leader: Meredith Bond (University of Maryland) |
| 7:30 pm - 8:00 pm | Jeffery Molkentin (Children's Hospital Medical Center)
"PKC alpha directly regulates cardiac contractility and calcium handling" |
| 8:00 pm - 8:30 pm | Peter Backx (University of Toronto)
"Mechanism for Regulation of Growth and Contractility by Action Potential Profile" |
| 8:30 pm - 9:00 pm | Joan Heller-Brown (University of CA/SD)
"Ca2+ and CaM kinase signaling in apoptosis and heart failure" |
| 9:00 pm - 9:30 pm | Late Breaking Science: Joshua Goldhaber (UCLA)
"Life without the sodium-calcium exchanger" |
| 9:30 pm | Opening Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Ca2+ Regulatory Proteins: Structure, Function and Pathophysiology |
| Discussion Leader: Jeff Robbins (University of Cincinnati) |
| 9:00 am - 9:30 am | Paul Allen (Brigham and Women's Hospital)
"Structure-Function Relationships for the Ryanodine Receptor" |
| 9:30 am - 10:00 am | Steven Marx (Columbia University)
"Ion channel regulation through macromolecular complexes" |
| 10:00 am - 10:30 am | Larry Jones (Indiana University)
"Molecular Interactions between Phospholamban and SERCA2a Probed with Cross-linking Reagents" |
| 10:30 am - 11:00 am | Coffee break / Photo Session |
| 11:00 am - 11:30 am | Donald Hilgemann (University of Texas Southwestern Medical Center)
"Direct measurements of ion fluxes mediated by cardiac Na transporters
-- new insights into old problems" |
| 11:30 am - 12:00 pm | David Eisner (University of Manchester)
"Stability and alternans of the calcium transient" |
| 12:00 pm - 12:30 pm | Late Breaking Science: John Colyer (University of Leeds)
"Engineering the Selective Degradation of PLB as a therapeutic Target" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Excitation-Contraction coupling in normal and diseased hearts |
| Discussion Leader: Jon Lederer (University of Maryland) |
| 7:30 pm - 8:00 pm | Heping Cheng (NIA/NIH)
"Calcium Blinks in the Sarcoplasmic Reticulum" |
| 8:00 pm - 8:30 pm | Martin Morad (Georgetown University)
"Naked & Dressed Ryanodine Receptors: Calcium cross-signaling and multiplicity of atrial gating" |
| 8:30 pm - 9:00 pm | Thomas Shannon (Rush University School of Medicine)
"Excitation-Contraction Coupling and Sarcoplasmic Reticulum Ca Leak in Diseased Hearts" |
| 9:00 pm - 9:30 pm | Karin Sipido (University of Leuven)
"Alterations in excitation-contraction coupling in the chronically ischemic myocardium" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cardiac Rhythm Generation and Arrhythmias |
| Discussion Leader: Donald Bers (Loyola University) |
| 9:00 am - 9:30 am | Franz Hoffman (Institute for Pharmacology and Toxicology)
"Cardiac Rhythm Generation by Pacemaker Channels" |
| 9:30 am - 10:00 am | Edward Lakatta (NIH/NIA)
"A General Mechanism for Cardiac Chronotropy and Inotropy" |
| 10:00 am - 10:30 am | Jim Weiss (University of California, Los Angeles)
"Intercellular Ca cycling and the stability of reentrant cardiac arrhythmias" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Greg Morley (New York University)
"Establishment of and disruption of the conduction system network" |
| 11:30 am - 12:00 pm | Mani Pashmforoush (UCSD Department of Medicine)
"New Genetic Pathways for Cardiac Arrhythmogenesis" |
| 12:00 pm - 12:30 pm | Late Breaking Science: TBA |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Ion channel biophysics and trafficking |
| Discussion Leader: David Yue (John Hopkins University) |
| 7:30 pm - 8:00 pm | Henry Colcraft (John Hopkins University)
"Structural determinants of auxiliary calcium-channel beta subunit modulation of cardiac L-type channel gating and trafficking" |
| 8:00 pm - 8:30 pm | Jeffery Saffitz (Washington University)
"Mechanisms of electrical uncoupling in acute ischemia" |
| 8:30 pm - 9:00 pm | Sylvan Richard (INSERM)
"Ca2+- induced Ca2+ entry" |
| 9:00 pm - 9:30 pm | Late Breaking Science: Ernst Niggli
"The good, the bad, and the ugly: local Ca2+ signals overshadowed by global Ca2+ transients after ß-adrenergic stimulation" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Death, Failure and Recovery of the Heart (I) |
| Discussion Leader: Jeffery Molkentin (Children's Hospital Medical Center) |
| 9:00 am - 9:30 am | Peipei Ping (University of California Los Angeles)
"Functional Proteomic Analysis of the Cardiac ANTI Sub-proteome" |
| 9:30 am - 10:00 am | Leslie Leinwand (University of Colorado)
"Molecular Mechanisms of Cardiac Adaptation" |
| 10:00 am - 10:30 am | Christine Seidman (Harvard Medical Center)
"Insights into Cardiac Biology from Human Heart Failure" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Jennifer Van Eyck (John Hopkins University)
"Proteomics uncover novel proteins in heart failure" |
| 11:30 am - 12:00 pm | Dan Kelly (Washington University)
"Metabolic plasticity of the normal and failing heart" |
| 12:00 pm - 12:30 pm | Annarosa Leri (New York Medical College)
"Cardiac stem cell niches and myocardial recovery" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Death, Failure and Recovery of the Heart (II) |
| Discussion Leader: Michael Artman (NYU) |
| 7:30 pm - 8:00 pm | Richard Kitsis (Albert Einstein College of Medicine)
"ARC, a Master-Repressor of Apoptosis in Cardiac Myocytes" |
| 8:00 pm - 8:30 pm | Walter Koch (Jefferson University)
"Novel Molecular Therapeutic Approaches for Heart Failure" |
| 8:30 pm - 9:00 pm | Kenneth Margulies (Temple University)
"The Emerging Biology of Myocardial Recovery" |
| 9:00 pm - 9:30 pm | Late Breaking Science: Abdelkarim Sabri (Temple University)
"Focal Adhesion Kinase Downregulation in Cardiocyte Anoikis: Role of EGF Receptor Transactivation" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling within Microdomains |
| Discussion Leader: Rui Ping Xiao (NIA/NIH) |
| 9:00 am - 9:30 am | Susan Steinberg (Columbia University)
"Protein kinase C signaling in cardiomyocyte caveolae" |
| 9:30 am - 10:00 am | Edwin Moore (University of British Columbia)
"Regional variations in caveolar occupants, and in their neighbouring organelles, can create location specific signaling domains" |
| 10:00 am - 10:30 am | Mark Sussman (SDSU)
"Over'Akt'ing in the nucleus: a healthier heart?" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Elizabeth Murphy (NIEHS/NIH)
"Sex, Calcium and Cardiac Injury" |
| 11:30 am - 12:00 pm | Howard Rockman (Duke University)
"Novel Mechanisms of Beta Adrenergic Receptor Signaling" |
| 12:00 pm - 12:30 pm | Late Breaking Science: Mark Anderson (Vanderbilt University)
"Calmodulin Kinase Inhibition as Therapy for Structural Heart Disease" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session IV |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Speaker |
| Discussion Leader: Steven Houser (Temple University) |
| 7:30 pm - 8:30 pm | Eric Olson (UT Southwestern)
"Small Molecules and Mechanisms for Manipulating Myocardial Growth" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
