SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ca2+ Regulatory Proteins |
| Discussion Leader: David Eisner (Manchester University) |
7:30 pm - 7:55 pm | Kurt Beam (University of Colorado)
"EC coupling: lessons from skeletal muscle" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Wayne Chen (University of Calgary)
"Ryanodine receptor-associated cardiac arrhythmias: abnormal store-overload induced Ca release" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Sandor Gyorke (Ohio State University)
"Regulation and deregulation of ryanodine receptors by luminal proteins in cardiac disease" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short presentation: Christian Soeller (University of Aukland)
"The three-dimensional distribution of ryanodine receptor clusters in rat ventricular myocytes" |
9:30 pm | Opening reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ca2+ in Contractility |
| Discussion Leader: Martin Morad (Georgetown University) |
9:00 am - 9:25 am | Bjorn Knollmann (Vanderbilt University)
"Keeping pace with Ca2+: role of calsequestrin in heart rhythm" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Shey-Shing Sheu (University of Rochester)
"Crosstalk Ca2+ signaling between mitochondria and SR during cardiac EC coupling" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Clive Orchard (University of Bristol)
"Cardiac T-tubules: Ca2+ handling microdomains" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Andy Trafford (University of Manchester)
"How the heart copes with age and disease" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Short presentation: Marcel Egger (University of Berne)
"Sub-cellular photorelease of InsP3 in living cells induced by two-photon excitation" |
12:00 pm - 12:10 pm | Short presentation: Dobromir Dobrev (University of Dresden)
"Regulation of Ca2+ handling proteins in AF" |
12:10 pm - 12:20 pm | Short presentation: Hena Ramay (George Mason University)
"A computational study of the role of different Ca2+ release site arrangements on Ca2+ dynamics in rat cardiac myocytes" |
12:45 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling |
| Discussion Leader: Joan Heller Brown (UCSD) |
7:30 pm - 7:55 pm | Jeff Molkentin (University of Cincinnati)
"Mouse models with altered Ca2+ handling identify the hypertrophy-inducing calcium pool" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Yibin Wang (UCLA)
"Molecular signaling in cardiac hypertrophy and arrhythmia: primary vs. secondary" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Litsa Kranias (University of Cincinnati)
"Hsp20: A prominent regulator of cardioprotection" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short presentation: Cecilia Mundina-Weilenmann (National University of La Plata)
"Dual role of CamKII in ischemia/reperfusion injury" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Channels, Transporters, and Function |
| Discussion Leader: Ed Lakatta (NIA) |
9:00 am - 9:25 am | Chalk Talk: Mark Anderson (University of Iowa)
"Does the fun ever stop? New faces on calmodulin's multi-faceted regulation of L-type Ca2+ current" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Chalk Talk: Don Hilgemann (UTSW)
"Regulation of cardiac ion transporters by endo- and exocytosis" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Jerry Lingrel (University of Cincinnati)
"Role of the ouabain binding site of the Na,K-ATPase in blood pressure regulation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Xander Wehrens (Baylor College of Medicine)
"Altered ryanodine receptor regulation in cardiac disease" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Richard Vaughan-Jones (Oxford University)
"Spatial regulation of intracellular pH: gap junctions versus membrane transporters" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Rhythms and Arrhythmias |
| Discussion Leader: Jim Weiss (UCLA) |
7:30 pm - 7:55 pm | Jeff Saffitz (Harvard University)
"Mechanisms linking electrical and contractile dysfunction in non- ischemic cardiomyopathies" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Colleen Clancy (Cornell University)
"Genetics and arrhythmia mechanisms: Insights from theoretical models" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Kevin Donahue (Metrohealth Hospital)
"Regulation of cardiac electrophysiology by somatic gene transfer" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short presentation: Ariel Escobar (Texas Tech University)
"Subcellular basis of T-wave alternans" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stress, Strain, and Microdomains |
| Discussion Leader: Karin Sipido (University of Leuven) |
9:00 am - 9:25 am | John Solaro (University of Illinois, Chicago)
"Remote control of A-band cardiac thin filaments by the I-Z-I protein network of cardiac sarcomeres" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Ed Moore (University of British Columbia)
"SR Ca release sites are not created equal" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Peter Mohler (Vanderbilt University)
"Dysfunction in ankyrin-based pathways and human cardiac arrhythmia" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Meredith Bond (University of Maryland, Baltimore)
"AKAP scaffolding proteins in the heart" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Elizabeth McNally (University of Chicago)
"Molecular mechanisms of vascular spasm" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| David Eisner and Jon Lederer (Vice Chairs) |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Pathophysiology of EC Coupling |
| Discussion Leader: Larry Jones (Indiana University) |
7:30 pm - 7:55 pm | Don Bers (Loyola University)
"Ca in excitation-transcription coupling" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Barbara Casadei (Oxford University)
"The emerging role of nNOS in myocardial remodeling and EC coupling" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Elizabeth Murphy (NIEHS)
"Role of altered ion transport in myocyte cell death and cardioprotection" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short presentation: Long-Sheng Song (University of Maryland, Baltimore)
"Transverse tubule remodelling, orphaned ryanodine receptors and Ca2+ instability in the failing heart" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Death, Failure, and Repair |
| Discussion Leader: Jon Lederer (University of Maryland, Baltimore) |
9:00 am - 9:25 am | Jeff Robbins (University of Cincinnati)
"Animal models of novel pathways leading to cardiomyopathy" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Steve Houser (Temple University)
"Calcium regulation in cardiac stem cell derived adult ventricular myocytes" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Rui-Ping Xiao (NIA, NIH)
"Beta-adrenergic subtype stimulation and the fate of cardiomyocytes" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Michael Rubart (Indiana University)
"Imaging cell-to-cell heterogeneity of calcium handling in whole mouse hearts using multiphoton microscopy" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Christine Seidman (Harvard University)
"HCM: Moving from gene to mechanism" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Speaker |
| Discussion Leader: Ken Philipson (UCLA) |
7:30 pm - 8:30 pm | Andrew McCulloch (UCSD)
"Cardiac systems biology" |
8:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |