SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Novel Methods for Studying Cardiovascular Disease |
| Discussion Leaders: Steve Houser (Temple University, Phila, PA) and Masao Endoh (Yamagata, Japan) |
7:35 pm - 8:00 pm | Howard Rockman (Duke University, Durham, NC)
"New models for cardiovascular disease"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Karl-Ludwig Laugwitz (Universität München, Munich, Germany)
"iPS models for arrhythmias"
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8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:03 pm | Eva Van Rooij (miRagen Therapeutics, Boulder, CO)
"micro RNAs as tools for studying cardiovascular disease"
|
9:03 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Mark Kohr (NHLBI, NIH)
"Novel methods to measure S-nitrosylation" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial Signaling and Cardiac Function |
| Discussion Leaders: Bob Balaban (NHLBI/NIH) and Edward Chouchani (Cambridge University, UK) |
9:00 am - 9:25 am | Paul Brookes (Rochester Univ, NY)
"Regulation of the mitochondrial KATP channel"
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9:25 am - 9:35 am | Discussion |
9:35 am - 9:53 am | Elena Dedkova (Rush University, Chicago, IL)
"Mitochodrial Ca transients"
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9:53 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Godfrey Smith (University ofGlasgow, UK)
"Mitochondrial regulation of Ca dynamics"
|
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Peipei Ping (UCLA, CA)
"Metabolic Labeling Reveal Novel Properties of Proteome Dynamics and Protein Kinetics in Mouse Mitochondria"
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11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Luca Scorrano (University of Geneva, Geneva, Switzerland)
"Mitochondrial dynamics and cardiovascular function"
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12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Point-Counterpoint: Is there a mitochondrial localized NOS?
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| Elena Dedkova (Rush University Medical Center) and Paul Brookes (Univ. Rochester. Med. Ctr.) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ion channel protein defects and arrhythmias |
| Discussion Leaders: David Eisner (Manchester Univ, UK) and Henry Colcraft (Columbia University, NY)
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7:30 pm - 7:55 pm | David Yue (Johns Hopkins University, Baltimore, MD)
"Nanodomain Ca2+ of Ca channels detected by a tethered genetically encoded Ca2+ sensor"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Stephane Hatem (INSERM/UPMC, Paris, France)
"K channel regulation and trafficking"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:58 pm | Tom Hund (Ohio State Univeristy, Columbus, OH)
"Ankyrin-B Dysfunction and Arrhythmias"
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8:58 pm - 9:05 pm | Discussion |
9:05 pm - 9:23 pm | Niall Macquaide (University of Leuvin, Belgium)
"RyRs in persistent atrial fibrillation"
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9:23 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Intersection of Signaling Kinases and Hypertrophy |
| Discussion Leaders: Wally Koch (Temple University, Phila, PA) and Alicia Mattiazzi (Centro de Investigaciones Cardiovascular, Ls Plata, Argentina)
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9:00 am - 9:25 am | Mark Sussman (SDSU, San Diego, CA)
"Kinase singaling and hypertrophy"
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9:25 am - 9:35 am | Discussion |
9:35 am - 9:53 am | Jeffrey Erickson (UC Davis, Davis, CA)
"FRET sensor Camui: insights into mechanisms of CaMKII activation"
|
9:53 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:55 am | Daria Mochly-Rosen (Stanford University, Stanford, CA)
"delta PKC and regulation of pyruvate dehydrogenase kinase"
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10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Roberta Gottlieb (SDSU, San Diego, CA)
"Role of mitophage in cardiac disease"
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11:30 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Steve Roof (Ohio State University, Columbus, OH)
"Indispensable Role of Neuronal Nitric Oxide Synthase for the Adaptive Cardiac Effects of Exercise"
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11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Eef Dries (University of Leuvin, Belgium)
"CaMKII activation differentially regulates coupled and non-coupled RyR in pig ventricular myocytes" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Seth Robia (Loyola University, Chicago, IL)
"SERCA domains measured by FRET" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Mechanisms and Targets for Redox Signaling |
| Discussion Leaders: Mark Anderson (University of Iowa, Iowa City, IA) and Bjorn Knollmann (Vanderbilt Univ, TN)
|
7:30 pm - 7:55 pm | Jun Sadoshima (UMDNJ, Newark, NJ)
"Identification of novel targets of thioredoxin1 in the heart by thioredoxin-trap mutant"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Barbara Casadei (Oxford University, Oxford, UK)
"Tetrahydrobiopterin-mediated regulation of myocardial excitation-contraction coupling"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Jenny Van Eyk (Johns Hopkins, Baltimore, MD)
"Proteomic changes in resynchronization therapy"
|
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | B. Daan Westenbrink (UCSD, San Diego, CA)
"CaMKIId induces mitochondrial oxidative stress and mediates Gaq induced heart failure, by suppressing UCP3" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Via Contractile Proteins |
| Discussion Leaders: Litsa Kranias (University of Cincinnati, OH) and Lea Delbridge (University of Melbourne, Australia) |
9:00 am - 9:25 am | Jolanda Van der Velden (University Medical Center Amsterdam, Netherlands)
"Phosphorylation and redox regulation of sacromere" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jeff Robbins (Cincinnati Children's Hosp, OH)
"Myosin-binding protein C and signaling"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | John Solaro (University of Ilinois at Chicago, IL)
"Phosphorylation and redox regulation of sacromere"
|
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Mathias Gautel (King's College London, London, UK)
"Cytoskeletal protein kinases"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Josh Goldhaber (Cedar Sinai Hospital, Los Angeles, CA)
"Loss of NCX in atrial cells"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Sabine Huke (Vanderbilt University, TN)
"Focal hypoxia and rapid changes in gap junctions in mouse hearts with Ca sensitized myofilament"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Novel Regulation of Ca2+ Dynamics |
| Discussion Leaders: Don Bers (UC Davis, Davis, CA) and Julie Bossuyt (UC Davis) |
7:30 pm - 7:55 pm | Jon Lederer (University of Maryland, Baltimore, MD)
"X-ROS signaling in heart: discoveries and insight from a new signaling pathway"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Hector Valdivia (University of Wisconsin, Madison, WI)
"RyR and signaling"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:58 pm | William Louch (Oslo University, Norway)
"SERCA-KO and Ca dynamics"
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8:58 pm - 9:05 pm | Discussion |
9:05 pm - 9:23 pm | Kat Dibb (University of Manchester, UK)
"Atrial remodeling in heart failure"
|
9:23 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Importance of Location in Signaling |
| Discussion Leaders: Yibin Wang (UCLA, Los Angeles, CA) and Shirin Doroudgar (SDSU, CA) |
9:00 am - 9:25 am | David Kass (Johns Hopkins, Baltimore, MD)
"cGMP/PKG Signaling: A Moveable Feast" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Igor Efimov (Washington University, St. Louis, MO)
"Electrophysiological Remodeling of Human Failing Heart"
|
9:55 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Christian Soeller (University of Aukland, NZ)
"Localized Ca signaling"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Beth McNally (University of Chicago, IL)
"Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation"
|
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Jeffrey Saucerman (University of Virginia, VA)
"Network reconstruction and systems analysis of cardiac hypertrophy signaling" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Catherine Makarewich (Temple University, PA)
"Caveolae-targeted L-Type Ca2+ Channels Initiate Pathological Hypertrophy" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ravi Ballijepalli (Univ. of Wisconsin)
"Loss of Caveolin-3 results in prolongation of APD, altered ICa,L and Ito in ventricular myocytes from cardiac specific Cav-3 KO mice" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lecture |
| Discussion Leaders: Jeff Molkentin (Cincinnati Children's, OH) |
7:30 pm - 8:30 pm | Rosario Rizzuto (University of Padua, Italy)
"The Mitochondrial Ca2+ Uniporter: New Insights on Ca2+ Regulation"
|
8:30 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |