SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | New Technologies and Methods to Aid in Cardiac Studies |
| Discussion Leaders: Bjorn Knollmann (Vanderbilt University) and
PeiPei Ping (University of California, of Los Angeles) |
7:40 pm - 7:55 pm | Dietmar Kappes (Fox Chase Cancer Center)
"TALEN-Mediated Techniques for Generation of Mouse Models"
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Xianhua Wang (Peking University)
"Roles of Mitochondrial Flashes in ATP Homeostasis of Heart"
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8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Don Bers (University of California, Davis)
"Sensing and Imaging of Micro-Domain Calcium"
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8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | S.R. Wayne Chen (University of Calgary)
"The Ryanodine Receptor Store-Sensing Gate Controls Ca2+ Waves and Ca2+-Triggered Arrhythmias"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Niggli Ernst (University of Bern)
"Extracting Detailed Ca Signaling Information from Noisy Confocal Images"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | iPS Cells: A Window on Human Myocardial Biology and Disease |
| Discussion Leaders: Rongli Liao (Harvard University) and Ju Chen (University of California, San Diego)
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9:00 am - 9:20 am | Thomas Eschenhagen (University Medical Center of Hamburg Eppendorf)
"iPS Cells as Pharmacological and Toxicological Tool"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sean Wu (Stanford University)
"Problems with Transdifferentiation as a Model"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Andre Terzic (Mayo Clinic)
"Potential for Cardiac Regeneration with iPS Cells"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Nikhil Munshi (UT Southwestern)
"Reprogramming Cardiac Cell-Type Specificity" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #2: Pearl Quijada (University of California, San Diego)
"Enhancing Myocardial Repair with CardioChimeras"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #3: Nina Ullrich (Heidelberg University)
"Functional Characterization of Stem Cell-Derived Cardiomyocytes: A Comparative Study of Intercellular Communication"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #4: Huyn Seok Hwang (Vanderbilt University)
"iPSC-Derived Cardiomyocytes from a Patient with Hypertrophic Cardiomyopathy Exhibit Impaired SR Ca Handling but no Change in Cytosolic Ca Buffering Properties"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Right Heart Failure, Pulmonary Hypertension and Diastolic Heart Failure |
| Discussion Leader: Wen Chen (Temple University)
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7:30 pm - 7:50 pm | Evangelos D. Michelakis (University of Alberta)
"Pulmonary Hypertension and the Role of ER Stress and Mitochondrial Signaling: Translational Implications"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Joseph Metzger (University of Minnesota)
"Genetically Engineered Ca2+ Buffers to Treat Diastolic Dysfunction"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Long-Sheng Song (University of Iowa)
"Rescuing Right Heart Failure"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Poster Talk #5: Emily Tsai (Temple University) |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial Ca2+ and Ion Channels |
| Discussion Leaders: Karin Sipido (University of Leuven) and
W. Jonathan Lederer (University of Maryland)
|
9:00 am - 9:20 am | Robert Dirksen (University of Rochester, NY)
"Superoxide Flashes, Ca2+ and mPTP"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Brian O'Rourke (Johns Hopkins University)
"Protective K+ Channels in Cardiac Mitochondrial"
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9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Madesh Muniswamy (Temple University)
"The Gatekeeper of Mitochondrial Calcium Entry"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Shey-Shing Sheu (Thomas Jefferson University)
"Regulation of Mitochondrial Bioenergetics, ROS, and Fission by Ca2+"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Poster Talk #6: Robert (Nathan) Correl (Cincinnati Children's Hospital)
"Junctional Complex Protein Mitsugumin 29 Alters Ryanodine Receptor Sensitivity and is Protective in Dilated Cardiomyopathy"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Talk #7: Andrew Ackell (University of Iowa, Trainee)
"Mitochondrial CaMKII: A Novel Driver of Atrial Fibrillation in Mice"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Talk #8: Mark Ziolo (Ohio State University)
"Effects of Friedreich's Ataxia on Heart Function" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Roles and Regulation in microRNAs in the Heart |
| Discussion Leaders: Joseph Hill (UT Southwestern) and
Jonathan Satin (University of Kentucky)
|
7:30 pm - 7:50 pm | Chad Grueter (University of Iowa)
"Cardiac miRNA's Can Control Global Metabolism"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Donald Menick (Medical University of South Carolina, Charleston, SC)
"Specific Regulation of Cardiac miRNA by HDACs and Acetylation"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Stefanie Dimmeler (Goethe University of Frankfurt am Main)
"miRNA that Regulate Cardiac Aging and Function"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Yibin Wang (University of California, Los Angeles)
"Transcriptome Programming via mRNA-Splicing in Cardiac Development and Diseases"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial Metabolism in Physiology and Disease |
| Discussion Leaders: Steven Houser (Temple University) and Junichi 'Jun' Sadoshima (Rutgers University)
|
9:00 am - 9:20 am | Rong Tian (University of Washington)
"Mitochondrial Metabolism and Cardiac Susceptibility"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Dale Abel (University of Iowa)
"Lipid Regulation of Mitochondrial Dynamics"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Asa Gustafsson (University of California, San Diego)
"Mitochondrial Autophagy in Cardiac Disease"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Gerald Dorn (Washington University in St. Louis)
"Mito Fusion Talk"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Muthu Periasamy (Ohio State University Medical Center)
"Ca2+ Integrates Muscle Function with Metabolism"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Poster Talk #9: Sara Menazza (NHLBI)
"Impaired Nitroso-Redox Signaling Is Involved in Human Heart Failure"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk #10: Ryan Boudreau (University of Iowa, Trainee)
"Deciphering and Exploiting MicroRNA-Target Interactomes in Human Cardiac Tissues"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | What is New and Exciting in Ca2+ and Ion Channeling? |
| Discussion Leaders: Thomas Shannon (Rush University) and David Eisner (University of Manchester)
|
7:30 pm - 7:50 pm | Jeffrey Molkentin (Cincinnati Children's Hospital Medical Center)
"How Does Calcium Cause Muscular Dystrophy?"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Mark Anderson (University of Iowa)
"Circadian Rhythms Govern Cardiac Repolarization and Arrhythmogenesis"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Bjorn Knollmann (Vanderbilt University)
"Calmodulin Mutations and Arrhythmia - Exciting the Heart Without CaMKII"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Patrick Most (University of Heidelberg)
"S100A1 Regulates Diastolic RyR2 Activity Through NO-Dependent Posttranslational Modification" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Novel Signaling Pathways in Heart Disease |
| Discussion Leaders: Barbara Casadei (University of Oxford) and Peter Mohler (The Ohio State University)
|
9:00 am - 9:20 am | Maria Kontaridis (Harvard University)
"The Dichotomous Role of RhoA Signaling in Cardiomyocytes"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Walter Koch (Temple University)
"RhoA Signaling in the Heart"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Elizabeth 'Tish' Murphy (National Heart, Lung and Blood Institute)
"S-Nitrosylation as a Signaling Regulator in the Heart"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Burns Blaxall (Cincinnati Children's Hospital Medical Center)
"Small Molecule Inhibitors of GRK2 - Getting Closer!"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Dobromir Dobrev (University Duisburg-Essen)
"Nucleoside Diphosphate Kinase C as a Regular of G-Protein Signaling in the Heart" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:12 pm | Poster Talk #11: Lew Roderick (Braham Institute, UK)
"Contribution of Histone 3 Lysine 9 Methylation to the Cardiac Hypertrophic Response"
|
12:12 pm - 12:16 pm | Discussion |
12:16 pm - 12:26 pm | Poster Talk #12: Abdelkarin Sabri (Temple University)
"PAR-4 Inhibition Prevents Myocyte Apoptosis but Impairs Cardiac Healing and Function After Myocardial Ischemia"
|
12:26 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Mark Sussman (University of California, San Diego) |
7:30 pm - 7:40 pm | Poster Talk #13: Shirin Doroudgar (Chair, GRS, San Diego State University)
"The Role of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) in the Heart"
|
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:00 pm | Poster Talk #14: Jerry Curran (Vice-Chair, GRS, Ohio State University)
"EHD3 Mediates Integral Membrane Protein Trafficking and Maintains Electrical Excitability in the Heart"
|
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Poster Talk #15: Charles Gray (University of California, San Diego)
"CaMKIId Splice Variants Exert Differential Effects on Ischemia / Reperfusion Injury and NF-κB Signaling" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 9:15 pm | Joseph Wu (Stanford University)
"iPSCs for Modeling Inherited Cardiomyopathies"
|
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |