Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Cardiac Repair and Regeneration |
| Discussion Leaders: Mark Sussman (San Diego State University, USA) and Charles Hong (Vanderbilt University Medical Center, USA) |
7:40 pm - 8:00 pm | Charles Murry (University of Washington, USA) "Cardiac Regeneration Using Pluripotent Stem Cells in Large Animals" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Kai Wollert (Hannover Medical School, Germany) "Emerging Protein- and Small Molecule-Based Therapies for Cardiac Repair" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Wolfram Zimmerman (University Medical Center Gottingen, Germany) "Engineering Heart Repair" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | T.K. Feaster (Vanderbilt University, USA) "Making Better Human iPSC-Derived Cardiomyocytes" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial Function, Redox Signaling and Calcium Handling |
| Discussion Leaders: Asa Gustafsson (University of California, San Diego, USA) and Elizabeth Murphy (National Heart, Lung, and Blood Institute, NIH, USA) |
9:00 am - 9:20 am | Christoph Maack (Universitätsklinikum des Saarlandes, Germany) "Mitochondrial Energetics and Calcium Coupling in the Heart" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Natalia Shirokova (New Jersey Medical School / Rutgers University, USA) "Mitochondrial Dysfunction During Progression of Dystrophic Cardiomyopathy" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Jennifer Kwong (Cincinnati Children's Hospital Medical Center, USA) "Matching Cardiac Workload with ATP Production: Role of the Mitochondrial Ca2+ Uniporter" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Moshi Song (Washington University School of Medicine, USA) "Mitochondrial Dynamism in the Heart" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Michael Murphy (Mitochondrial Biology Unit, University of Cambridge, United Kingdom) "Mechanisms of Mitochondrial ROS Production in the Heart as Therapeutic Targets" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Selected from Poster Abstracts: Stephen Hurst (Thomas Jefferson University, USA) "Truncation of GSK-3 Beta in the Mitochondria Matrix Is the Master Switch of the mPTP" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Selected from Poster Abstracts: Ricardo Carnicer (University of Oxford, United Kingdom) "Protection Against Diabetic Cardiomyopathy: New Roles for BH4 and NO in the Heart" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cardiac Ageing and Rejuvenation |
| Discussion Leaders: Martin Morad (Medical University of South Carolina, USA) and Walter Koch (Temple University, USA) |
7:30 pm - 7:50 pm | Michael Ristow (Energy Metabolism Laboratory, ETH Zurich, Switzerland) "Mitohormesis in Aging" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Richard Lee (Brigham and Women's Hospital, USA) "Molecular Regulation of Cardiac Aging" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Satchidananda Panda (Salk Institute for Biological Studies, USA) "Time Restricted Feeding for Alleviation of Cardiac Disease" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Selected from Poster Abstracts: Christopher Traynham (Temple University, USA) "Loss of Endogenous Negative Regulation of GRK2 by S-Nitrosylation at Cysteine 340 Leads to Cardiovascular Dysfunction with Aging" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Ronald Vagnozzi (Cincinnati Children's Hospital Medical Center, USA) "Dual-Reporter Genetic Lineage Tracing to Assess the Paracrine Hypothesis of Cell Therapy for the Heart" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Myofilament Function in Health and Disease |
| Discussion Leaders: John Solaro (University of Illinois at Chicago, USA) and Jill Tardiff (University of Arizona, USA) |
9:00 am - 9:20 am | David Warshaw (University of Vermont College of Medicine, USA) "MyBP-C: Stepping on the Gas and Brake Simultaneously to Regulate Cardiac Contractility" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sakthivel Sadayappan (Loyola University Chicago, USA) "New Insights into the Role of MYBPC3 in Cardioprotection During Ischemia-Reperfusion Injury" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Jolanda Van Der Velden (VU University Medical Center, The Netherlands) "Myofilament (Dys)function in HCM" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:10 am | Aldrin Gomes (University of California, Davis, USA) "Proteasome (Dys)function in HCM" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Dan Beard (University of Michigan, USA) "Multi-Scale Modeling of Cardiac Energy Metabolism and Coronary Flow" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Sabine Huke (Vanderbilt University, USA) "Myocyte-Vascular Cross Talk in HCM" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Benjamin Prosser (University of Pennsylvania, USA) "Microtubule Role in Myocyte Mechanics" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Juan Bernal (Spanish National Centre for Cardiovascular Research (CNIC), Spain) "Genetic Changes During Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cell
to Cell Cross-Talk in the Heart |
| Discussion Leaders: Burns Blaxall (Cincinnati Children's Hospital Medical Center, USA) and Paula Da Costa-Martins (Maastricht University, The Netherlands) |
7:30 pm - 7:50 pm | Matthias Nahrendorf (Massachusetts General Hospital, USA) "Inflammatory Networks in Ischemic Heart Disease" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Stefan Engelhardt (Technische Universität München, Germany) "Myocytes and Fibroblasts" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Marco Mongillo (University of Padova, Italy) "Myocytes and Neurons" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Charalambos Antoniades (University of Oxford, United Kingdom) "Adipose Tissue and Myocardium" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Mechanism of Atrial Fibrillation |
| Discussion Leaders: Dobromir Dobrev (University of Duisburg-Essen, Germany) and Donald Bers (University of California, Davis, USA) |
9:00 am - 9:20 am | Pepe Jalife (University of Michigan, USA) "Atrial Fibrosis – Culprit or Bystander in Atrial Fibrillation?" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sander Verheule (Maastricht University, The Netherlands) "Metabolic Impact of AF" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Larissa Fabritz (Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom) "Does PITX2-Dependent Gene Regulation Promote Atrial Fibrillation?" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Maura Greiser (University of Maryland, USA) "Calcium Silencing in AF" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Xander Wehrens (Baylor College of Medicine, USA) "Calcium Triggering in AF" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Leonardo Sacconi (European Laboratory for Non-Linear Spectroscopy, Italy) "Measuring Electrical Conductibility of Cardiac T-Tubular System" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Przemyslaw Radwanski (The Ohio State University, USA) "Neuronal Na+ Channels in Conjunction with Na+/Ca+ Exchange Act as an Arrhythmogenic Trigger in Two Genetic Models of Calcium-Dependent Atrial Arrhythmias" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Calcium Signaling and EC Coupling |
| Discussion Leaders: Wayne Chen (University of Calgary, Canada) and Alicia Mattiazzi (Cardiovascular Research Center, National University of La Plata, Argentina) |
7:30 pm - 7:50 pm | Filip Van Petegem (University of British Columbia, Canada) "Structural Insights into the Architecture and Ligand Binding Properties of Ryanodine Receptors" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | David Eisner (University of Manchester, United Kingdom) "Regulation of Diastolic Calcium" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Ye Chen-Izu (University of California, Davis, USA) "Mechano-Chemo-Transduction During Cardiomyocyte Contraction" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Gil Bub (University of Oxford, United Kingdom) "Dye-Free Optical Mapping and Optogenetic Control of Excitation Waves" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Selected from Poster Abstracts: Andriy Belevych (The Ohio State University, USA) "The Role of Junctional- and Non-Junctional Ca Release Sites in the Generation of Arrhythmogenic Diastolic Ca Release in Myocytes from Failing Hearts" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Catherine Makarewich (University of Texas Southwestern Medical Center, USA) "DWORF: A Novel Muscle Specific Micropeptide that Enhances SERCA Activity and Myocyte Contractility" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Signaling in Myocardial Remodeling |
| Discussion Leaders: Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany) and Jeffery Molkentin (Cincinnati Children's Hospital, USA) |
9:00 am - 9:20 am | Paula Da Costa-Martins (Maastricht University, The Netherlands) "Non-Coding RNA Regulation of Myocardial Hypertrophy" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Thomas Braun (Max-Planck-Institute for Heart and Lung Research, Germany) "The Role of Dedifferentiated Cardiomyoctes in the Diseased Myocardium" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Jennifer Davis (University of Washington, USA) "Master Regulators of Cardiac Fibroblast Activation" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Sarah Franklin (University of Utah, USA) "Epigenetic Mechanisms Regulating Chromatin Structure in the Heart" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Roger Hajjar (Icahn School of Medicine at Mount Sinai, USA) "SERCA2a and Beyond" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Ulrike Mende (Rhode Island Hospital / Brown University, USA) "Regulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in Innovative 3D In Vitro Cellular Cross-Talk Platforms" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Kevin Bersell (Vanderbilt University, USA) "Genome Editing in iPSCs Establishes that a Rare TBX5 Variant Causes the Brugada Syndrome" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Harnessing Big Data for Basic Discovery |
| Discussion Leaders: Thomas Eschenhagen (University Medical Center Hamburg Eppendorf, Germany) and Brian O'Rourke (Johns Hopkins University, USA) |
7:30 pm - 7:50 pm | Patrick Ellinor (Massachusetts General Hospital / Broad Institute, USA) "Making Functional Sense of GWAS Data" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Dan Roden (Vanderbilt University Medical Center, USA) "Phenome-Wide Association Studies - From Patients to Molecules" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Christine Seidman (Harvard Medical School, USA) "New Discoveries in Human Cardiomyopathies" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |