Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Aspects of Cardiac Regeneration, Repair and Development
Discussion Leaders: Maria Kontaridis (Masonic Medical Research Laboratory / Beth Israel Deaconess Medical Center, USA) and William Pu (Harvard Medical School / Boston Children's Hospital, USA)
7:40 pm - 8:00 pm
Miguel Torres (Spanish National Cardiovascular Research Centre (CNIC), Spain)
"Live Analysis of Mammalian Heart Formation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Chulan Kwon (Johns Hopkins University, USA)
"Pluripotent Stem Cell-Derived Cardiac Cells: Heterogeneity and Maturation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Jop van Berlo (University of Minnesota, USA)
"Cardiac Regeneration by Side Population Cells"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Nipavan Chiamvimonvat (University of California, Davis, USA)
"Electrotaxis of Cardiac Progenitors and Fibroblasts"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathophysiological Signal Transduction in Myocardial Remodeling
Discussion Leaders: W. Jonathan Lederer (University of Maryland School of Medicine, USA) and Chris Glembotski (SDSU Heart Institute, USA)
9:00 am - 9:20 am
Jeffrey Saucerman (University of Virginia, USA)
"Deciphering the Cardiac Fibroblast Signaling Network"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Walter Koch (Temple University, USA)
"G Protein-Coupled Receptor Kinases and Beta-Adrenergic Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kimberly Dodge-Kafka (UConn Health, USA)
"Regulation of Cardiac Hypertrophy by the A-Kinase Anchoring Protein mAKAP"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Emilio Hirsch (University of Torino, Italy)
"Multifaceted Roles of PI3K in the Heart"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Chris de Korte (Radboud University Medical Center Nijmegen, The Netherlands)
"Advances in Ultrasound Technology for Precision Medicine"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany) and Maria Kontaridis (Masonic Medical Research Laboratory / Beth Israel Deaconess Medical Center, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of the Heart by Non-Coding RNAs and Chromatin
Discussion Leaders: Federica Accornero (Ohio State University, USA) and Stefan Engelhardt (Technische Universität München, Germany)
7:30 pm - 7:50 pm
Susmita Sahoo (Icahn School of Medicine at Mount Sinai, USA)
"Exosomes and Epitranscriptome in Cardiac Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Saptarsi Haldar (Gladstone Institutes / University of California, San Francisco, USA)
"Drugging Transcription in Heart Failure"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Thomas Thum (Hannover Medical School, Germany)
"Long Non-Coding RNAs in Cardiovascular Medicine"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Reinier Boon (VU University Amsterdam, The Netherlands)
"Long Non-Coding RNAs in Cardiac Aging"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic and Mitochondrial Dysfunction in Cardiovascular Disease
Discussion Leaders: Lea Delbridge (University of Melbourne, Australia) and Elizabeth Murphy (National Heart, Lung, and Blood Institute, NIH, USA)
9:00 am - 9:20 am
Jun Sadoshima (Rutgers New Jersey Medical School, USA)
"The Molecular Mechanism of Lipotoxicity in Response to High Fat Diet Feeding"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rosario Rizzuto (University of Padova, Italy)
"Mitochondrial Ion Transport Mechanisms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rong Tian (University of Washington, USA)
"Impaired Mitochondrial Function in Heart Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Dale Abel (University of Iowa, USA)
"Myocardial Insulin Signaling and Heart Failure"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mark Anderson (Johns Hopkins University, USA)
"Evolution of CaMKII Oxidation: Implications for Physiology and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Jonathan Lambert (Lewis Katz School of Medicine, Temple University, USA)
"MCUB Regulates the Molecular Composition of the Mitochondrial calcium Uniporter Channel to Limit Mitochondrial Calcium Overload"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Liming Pei (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Single-Nucleus Transcriptomic Survey of Cell Diversity and Functional Maturation in the Postnatal Mammalian Hearts"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of Non-Myocytes in Cardiac Regulation
Discussion Leaders: Jennifer Davis (University of Washington, USA) and Mirko Voelkers (University Hospital Heidelberg, Germany)
7:30 pm - 7:50 pm
Serena Zacchigna (University of Trieste / International Centre for Genetic Engineering and Biotechnology, Italy)
"Multi-Cellular Cross-Talk Regulating Cardiac Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Raj Kishore (Temple University, USA)
"Inflammation Inhibits Bone Marrow Progenitor Cell Exosomes Cargo and Their Myocardial Repair Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
David Paterson (University of Oxford, United Kingdom)
"Neuronal Regulation of Cardiac Excitability: Role of Cyclic Nucleotide Coupled Phosphodiesterases"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christian Soeller (University of Exeter, United Kingdom)
"Fibroblasts, Collagen and Transverse Tubules of Ventricular Myocytes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aberrant Ca Signaling and Arrhythmia Mechanisms
Discussion Leaders: Karin Sipido (KU Leuven, Belgium) and Dmitry Terentyev (Rhode Island Hospital / Alpert Medical School, Brown University, USA)
9:00 am - 9:20 am
Bjorn Knollmann (Vanderbilt University School of Medicine, USA)
"Cellular Origin of Ventricular Ectopy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Donald Bers (University of California, Davis, USA)
"Arrhythmogenic SR Ca-Release Mechanisms in Heart Failure"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mario Delmar (New York University School of Medicine, USA)
"Plakophilin-2 in the Regulation of Ca and Rhythm"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
John Elrod (Temple University, USA)
"Novel Regulatory Mechanisms in Mitochondrial Calcium Uptake"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Geoffrey Pitt (Weill Cornell Medicine, USA)
"FGF13 as a Na Channel Auxilliary Subunit"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Adrian Arrieta (San Diego State University, USA)
"MANF, a Structurally Unique Redox-Sensitive Chaperone, Restores ER-Protein Folding and Mitigates Ischemia/Reperfusion Damage in the Heart"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Cristina del Carmen (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
"Missense Mutation in Plakophilin-2 Mediates Reduction in Sodium Currents in ARVC hiPSC-CM"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulation of and by Myofilaments
Discussion Leaders: Benjamin Prosser (Perelman School of Medicine, University of Pennsylvania, USA) and John Morrow (Columbia University, USA)
7:30 pm - 7:50 pm
Stuart Campbell (Yale University, USA)
"Biomechanical Phenotypes of Cardiomyocytes Derived from Hypertrophic Cardiomyopathy Patient iPSCs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Anthony Cammarato (Johns Hopkins University, USA)
"The Actin 'A-Triad's' Role in Contractile Regulation in Health and Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michael Gotthardt (Max Delbrück Center for Molecular Medicine, Germany)
"A Visual and Omics Approach to Sarcomere Dynamics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Yingxian Chen (University of Pennsylvania, USA)
"Suppressing Detyrosinated Microtubules Improves Myocyte Function in Human Heart Failure"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Janet Lighthouse (University of Rochester Medical Center, USA)
"Exercise Promotes a Cardioprotective Gene Program in Resident Cardiac Fibroblasts"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Technologies and Therapies
Discussion Leaders: Jolanda van der Velden (VU University Medical Center, The Netherlands) and Seth Robia (Loyola University Chicago, USA)
9:00 am - 9:20 am
Thomas Vondriska (University of California, Los Angeles, USA)
"Dynamics of Chromatin Structure in Heart Failure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Amedee des Georges (City University of New York, USA)
"Insights into Ryanodine Receptor Ligand Binding and Gating Using Cryo-EM and Geometric Machine Learning"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Samantha Harris (University of Arizona, USA)
"Cutting and Pasting Myofilament Proteins with Spy-C Mice"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jennifer Van Eyk (Cedars-Sinai Medical Center, USA)
"Future Directions in Proteomics: Proteome Dynamics and Novel Isoform Detection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany)
"Gene Therapy for Myofilament Disorders"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Danny El-Nachef (University of Washington, USA)
"A Two-Hit Model for Cardiac Myocyte Proliferation: Relieving Epigenetic Blockade and Activating Mitogenic Pathways"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Catherine Makarewich (University of Texas Southwestern Medical Center, USA)
"Discovery of MOXI, a Mitochondrial Micropeptide that Regulates Fatty Acid Beta-Oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Translating Mechanisms to Therapies
Discussion Leaders: Jil Tardiff (University of Arizona, USA) and Christoph Maack (University Clinic Würzburg, Germany)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
David Kass (Johns Hopkins University School of Medicine, USA)
"Broadening the Therapeutic Potential of a Protein Kinase G Interactome"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Jeffery Molkentin (Cincinnati Children's Hospital Medical Center, USA)
"The 5 Thrombospondin Genes Generate an Intracellular Distribution Network"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure