Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Cardiac Repair and Regeneration
Discussion Leaders: Bjorn Knollmann (Vanderbilt University School of Medicine, United States) and Jop van Berlo (University of Minnesota, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Mauro Giacca (King's College London, United Kingdom)
"MicroRNA Therapy After Myocardial Infarction"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Wolfram Zimmerman (University Medical Center Göttingen, Germany)
"Repairing Failing Hearts with Engineered Heart Muscle"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Lay Ping Ong (Wellcome-MRC Stem Cell Institute, University of Cambridge, United Kingdom)
"Epicardially-Secreted Fibronectin Mediates Epicardial-Myocardial Crosstalk to Drive hESC-Cardiomyocytes’ Maturation in 3D-Engineered Heart Tissues"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Myocellular Structural Dynamics in Health and Disease
Discussion Leader: Jolanda van der Velden (Amsterdam UMC, The Netherlands)
9:00 am - 9:20 am
Farah Sheikh (University of California San Diego, United States)
"Desmosomal Dysfunction in ARVC/D"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Brett Colson (University of Arizona, United States)
"Changes in Actin Dynamics in Cardiac Remodeling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maria Kontaridis (Masonic Medical Research Institute, United States)
"Cellular Mechanisms in Rare Structural Cardiomyopathies"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Wolfgang Linke (University of Münster, Germany)
"Titin Truncations in Dilated Cardiomyopathy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Juan A Bernal (Spanish National Centre for Cardiovascular Research (CNIC), Spain)
"Actomyosin Regulation for Arrhythmogenic Cardiomyopathy Treatment"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jourdan Ewoldt (Boston University, United States)
"Aberrant Paracrine Signaling of MYH7-Variant Cardiomyocytes Drives Stromal Activation in Hypertrophic Cardiomyopathy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Rong Tian (University of Washington, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Excitation-Contraction Coupling and Arrhythmias
Discussion Leaders: Donald Bers (University of California, Davis, United States) and Steven Houser (Temple University School of Medicine, United States)
7:30 pm - 7:50 pm
Isabelle Deschenes (The Ohio State University , United States)
"Coupled Gating of Na+ Channels"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sara Liin (Linköping University, Sweden)
"Molecular Targeting of K+ Channels in Long QT syndrome"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Xander Wehrens (Baylor College of Medicine, United States)
"Ca2+-Dependent Mechanisms of Arrhythmias"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Matthew Daniels (Manchester University, United Kingdom)
"Novel Ca2+ Indicators Targeted to Sarcomeres"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammatory Response in Cardiac Remodeling
Discussion Leader: Jeffery Molkentin (Cincinnati Children's Hospital Medical Center, United States)
9:00 am - 9:20 am
Gustavo Ramos (University Hospital of Würzburg, Germany)
"Lymphocytes at the Heart of Wound Healing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Daniela Carnevale (Sapienza University of Rome and IRCCS Neuromed, Italy)
"Heart, Spleen, Brain: The Neuroimmune Axis of Cardiovascular Control"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Slava Epelman (University Health Network, Canada)
"Innate and Adaptive Immune Systems in Cardiac Injury and Repair"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Daniela Cihakova (Johns Hopkins University, United States)
"The Role of Pericardial Macrophages in Cardiac Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Kory Lavine (Washington University School of Medicine, United States)
"Novel PET Radiotracers for the Detection of I/R Injury"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Pilar Alcaide (Tufts University School of Medicine, United States)
"T Cell Mediated Immune Response in Heart Failure"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Technologies of Analysis in Cardiac Myocytes and Whole Hearts
Discussion Leader: Benjamin Prosser (University of Pennsylvania, United States)
7:30 pm - 7:50 pm
Roger Foo (National University Singapore, Singapore)
"Deep Epi-Genomic Analyses of Human Failing Hearts"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Federica Accornero (Ohio State University, United States)
"Analysis of RNA Modification"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jan Christoph (University of California, San Francisco, United States)
"Electromechanical Vortex Imaging in Ventricular Fibrillation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Izhak Kehat (Technion-Israel institute of technology, Israel)
"Live Imaging of Translation in Living Cardiomyocytes at Super-Resolution"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Mikako Harata (National Institute of Health, United States)
"Measuring Mitochondrial Calcium Using a Genetically-Encoded Lifetime-based Biosensor, Mito-TqFLITS, in Cardiomyocytes Derived from Induced Pluripotent Stem Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria and Metabolism: Complex Regulatory Mechanisms
Discussion Leaders: Elizabeth Murphy (National Institutes of Health, United States)
9:00 am - 9:20 am
Mathias Mericskay (Université Paris-Saclay, France)
"Nicotinamide Riboside for the Treatment of Heart Failure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
John Elrod (Temple University, United States)
"Metabolic Targets for Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Danielle Murashige (University of Pennsylvania, United States)
"Metabolic Rewiring of Substrate Utilization in Heart Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Johannes Backs (Heidelberg University, Germany)
"Oxidative Modification of Histone Deacetylases in Diastolic Dysfunction"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Yibin Wang (Duke-NUS Medical School, Singapore)
"Branched Chain Amino Acid Metabolism in Heart Failure"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Cancer and the Heart
Discussion Leader: Sumanth Prabhu (Washington University School of Medicine, United States)
7:30 pm - 7:50 pm
Aarti Asnani (Beth Israel Deaconess Medical Center, United States)
"Mechanisms and Prevention of Anthracycline Cardiotoxicity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Javid Moslehi (University of California, San Francisco (UCSF), United States)
"Cardiovascular Toxicities of Immune Checkpoint Inhibitors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Rudolf de Boer (University Medical Center Groningen, The Netherlands)
"Heart Failure Induces Tumor Growth"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Anja Karlstaedt (Cedars Sinai Medical Center, United States)
"Oncometabolite Control of Cardiac Function"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Approaches to Targeted Therapies
Discussion Leaders: Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany) and Thomas Vondriska (University of California, Los Angeles, United States)
9:00 am - 9:25 am
Laura Zelarayán (University of Göttingen, Germany)
"Crispr/Cas9-directed Gene Activation to Prevent Heart Failure"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Gabriele Schiattarella (Charité University Medical Center / Max Delbrück Center for Molecular Medicine, Berlin, Germany, Germany)
"Lipotoxicity and Metabolic Inflammation in HFpEF"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States)
"Epigenetic Approaches in HFpEF"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
William Pu (Boston Children's Hospital, United States)
"Inhibiting CaMKII in CPVT - Hereditary Cardiomyopathies"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Shannon Shearer (University of Cincinnati, United States)
"Absence of Periostin Affects Pathological Cardiac Fibroblast Activity"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Eric Schoger (University Medical Center Goettingen, Germany)
"Cardiomyocyte-Specific CRISPR/Cas9 Controlled KLF15 Expression in Stressed Mouse and Human Cardiomyocytes Prevents Hypertrophic Cardiac Remodeling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: From Primary Mechanism to Targeted Therapies for Cardiomyopathies
Discussion Leaders: Benjamin Prosser (University of Pennsylvania, United States) and Rong Tian (University of Washington, United States)
7:30 pm - 8:15 pm
Leslie Leinwand (University of Colorado Boulder, United States)
"Targeting Sarcomeres in Hereditary Cardiomyopathies"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Thomas Eschenhagen (University Medical Center Hamburg Eppendorf, Germany)
"Myths and Realities in Cardiac Regeneration"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure