| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Shifting
Paradigms and Evolving Mechanisms in Cardiac Biology |
| Discussion Leader: Shirin Doroudgar (Heidelberg University Hospital, Germany) |
| 3:45 pm - 3:55 pm | Sarah Schumacher (Temple University School of Medicine, USA)
"Domain-Specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure" |
| 3:55 pm - 4:00 pm | Discussion |
| 4:00 pm - 4:10 pm | Jillian Simon (University of Oxford, United Kingdom)
"Redox-Dependent Dimerization of PKA RI Regulates Calcium Handling Under Physiological Conditions" |
| 4:10 pm - 4:15 pm | Discussion |
| 4:15 pm - 4:25 pm | Sathya Unudurthi (The Ohio State University, USA)
"The Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Basic Discovery to Inform Human Cardiovascular Health and Disease / Mentorship Component: Panel Discussion |
| Discussion Leaders: Samuel Buxton (Baylor College of Medicine, USA), Jessica Caldwell (University of Manchester, United Kingdom) and Jerry Curran (Abiomed, Inc., USA) |
| 7:30 pm - 7:45 pm | Nieves Gomez-Hurtado (Vanderbilt University, USA)
"CaMKII-Dependent RyR2 Regulation in Arrhythmogenic CaM Syndromes" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Elaine Wan (Columbia University, USA)
"Incomplete Sodium Channel Inactivation Causes Spontaneous Atrial Fibrillation In Vivo and Ex Vivo in a Novel Mouse Model" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Klemen Ziberna (University of Oxford, United Kingdom)
"Myocardial Overexpression of GTP Cyclohydrolase 1 Promotes Atrial Arrhythmias" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:30 pm | Panel Discussion |
| "Project to Patent and Everything in Between: Hitting the Major Milestones of a Successful Research Program" |
|
- Peter Mohler (The Ohio State University College of Medicine, USA)
- Walter Koch (Temple University, USA)
- Donald Bers (University of California, Davis, USA)
- Suguna Rachakonda (NIH Center for Accelerated Innovations, Cleveland Clinic, USA)
- Gordon Pipes (Bristol-Myers Squibb, USA)
|
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Molecular Regulation of Cardiac Function and Dysfunction / The Dynamic Molecular World Outside the Cardiomyocyte |
| Discussion Leaders: Alexei Ilinykh (Monash University, Australia), Christopher Traynham (Temple University, USA), Pearl Quijada (University of Rochester Medical Center, USA) and Elza van Deel (VU University Medical Center, The Netherlands) |
| 9:00 am - 9:15 am | David Ryba (University of Illinois at Chicago, USA)
"Functional and Morphological Improvements Mediated by Long-Term ß-Arrestin Biased Agonism of the AT1R in Familial Dilated Cardiomyopathy" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Stephen Hurst (Thomas Jefferson University, USA)
"Truncation of GSK-3 Beta in the Mitochondria Matrix Is the Master Switch of the mPTP" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Randi Parks (National Heart, Lung, and Blood Institute, NIH, USA)
"Regulation of the Permeability Transition Pore Is Altered in Mice Lacking the Mitochondrial Calcium Uniporter" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:05 am | General Discussion |
| 10:05 am - 10:15 am | Jennifer Schwanekamp (Cincinnati Children's Hospital Medical Center, USA)
"Defining the Role of Transforming Growth Factor, Beta-Induced (BigH3) in Adverse Ventricular Remodeling" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Celinda Kofron (Rhode Island Hospital / Alpert Medical School, Brown University, USA)
"Regulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in Innovative 3D In Vitro Cellular Cross-Talk Platforms" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Emma Radcliffe (University of Manchester, United Kingdom)
"Heart Failure: A Nervous Approach" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Keynote Session: Genome-Wide Discovery at the Forefront of Cardiac Biology |
| Discussion Leader: Ronald Vagnozzi (Cincinnati Children's Hospital Medical Center, USA) |
| 1:30 pm - 1:45 pm | Catherine Makarewich (University of Texas Southwestern Medical Center, USA)
"Identification and Characterization of Novel Cardiac and Skeletal Muscle Specific Micropeptides" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:20 pm | Elizabeth McNally (Northwestern University, USA)
"Dissecting the Genetic Drivers of Cardiomyopathy at the Genomic Scale" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
