Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Novel Mechanisms in Heart Failure
Discussion Leaders: Adrian Arrieta (San Diego State University, USA) and Tobias Schips (Cincinnati Children's Hospital Medical Center, USA)
3:45 pm - 3:55 pm
Eva Riechert (University Hospital Heidelberg, Germany)
"Pras40 Translationally Regulates Growth Control in Diseased Myocardium"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Matthew Brody (Cincinnati Children's Hospital Medical Center, USA)
"Palmitoylation-Dependent Regulation of Rho Family Small GTPase Signaling and Heart Failure"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Antonia Zech (University Medical Center Hamburg-Eppendorf, Germany)
"Common Autophagy Alteration but Specific Lysosomal Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiomyocyte Structure and Dynamics / Models of Cardiac Remodeling and Disease
Discussion Leaders: Matthew Caporizzo (University of Pennsylvnaia, USA), Christopher Johnson (Vanderbilt University School of Medicine, USA), Sharon George (The George Washington University, USA) and Janet Lighthouse (University of Rochester Medical Center, USA)
7:30 pm - 7:40 pm
Yingxian Chen (University of Pennsylvania, USA)
"Suppressing Detyrosinated Microtubules Improves Myocyte Function in Human Heart Failure"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jessica Caldwell (University of Manchester, United Kingdom)
"Disordered yet Functional Atrial T-Tubules on Recovery from Heart Failure"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Daniel Blackwell (Vanderbilt University Medical Center, USA)
"Sarcoplasmic Reticulum-Dependent Mechanisms of Arrhythmogenic Calcium Release Inhibition by Flecainide"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Ingrid Bonilla (The Ohio State University, USA)
"Local Calcium Entry Signals (LoCES) in the Heart Are Spatially Defined Unitary Components of Cardiac SOCE, Which Are Upregulated in CPVT and Contribute to Calcium Triggered Arrhythmias"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Swati Dey (Johns Hopkins University, USA)
"Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Mauricio Lillo (Rutgers University, USA)
"S-Nitrosylation of Cx43 Hemichannels Causes Cardiac Arrhythmias in Muscular Dystrophy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Lee Meier (University of Minnesota, USA)
"CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ryan Burke (School of Medicine and Dentistry, University of Rochester Medical Center, USA)
"The Polyether Ionophore Antibiotic Salinomycin Confers Protection Against Ischemic and Non-Ischemic Heart Failure"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cardiomyocyte Maturation and Renewal / Mentorship Component: Panel Discussion
Discussion Leaders: Jessica Ivy (University of Edinburgh, United Kingdom) and Ronald Vagnozzi (Cincinnati Children's Hospital, USA)
9:00 am - 9:10 am
Yuxuan Guo (Boston Children's Hospital, USA)
"Hierarchical Regulation of Cardiomyocyte Maturation by Stage-Specific SRF Activity"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Danny El-Nachef (University of Washington, USA)
"A Two-Hit Model for Cardiac Myocyte Proliferation: Relieving Epigenetic Blockade and Activating Mitogenic Pathways"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Arica Beisaw (Max Planck Institute for Heart and Lung Research, Germany)
"Elucidating the Role of Jun/Fos Transcription Factors in Regulating Chromatin Dynamics During Zebrafish Cardiac Regeneration"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Maksymilian Prondzynski (University Medical Center Hamburg-Eppendorf, Germany)
"CRISPR/Cas9 Genome Editing Repairs a Novel ACTN2 Mutation and Prevents the Disease Phenotype in Human iPSC-Derived Cardiomyocytes and Engineered Heart Tissue"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Navigating Your Way to a Successful Career in Science
Timothy McKinsey (University of Colorado Anschutz Medical Campus, USA)
Jeffery Molkentin (Cincinnati Children's Hospital Medical Center, USA)
Nicole Purcell (University of California, San Diego, USA)
Rachel Roth Flach (Pfizer, USA)
Eric Small (University of Rochester Medical Center, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Keynote Session: New Trends in Cardiac Regeneration and Repair
Discussion Leaders: Pearl Quijada (University of Rochester Medical Center, USA) and Catherine Makarewich (University of Texas Southwestern Medical Center, USA)
1:30 pm - 2:20 pm
William Pu (Harvard Medical School / Boston Children's Hospital, USA)
"Engineered Tissue Models of Inherited Heart Disease"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes