Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Carotenoids: From Plants to Mammals
Discussion Leaders: Eleanore Wurtzel (Lehman College / The Graduate Center, City University of New York, United States) and Earl Harrison (Ohio State University, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Johannes Von Lintig (Case Western Reserve University, United States)
"Aster la Vista: Unraveling the Biochemical Basis of Ocular Carotenoid Homeostasis"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:35 pm
Introduction by Discussion Leader
8:35 pm - 9:05 pm
Volker Wendisch (Bielefeld University, Germany)
"Biosynthesis and Biotechnological Production of Carotenoids in Corynebacterium Glutamicum "
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biosynthesis and Enzymology
Discussion Leaders: Joseph Hirschberg (The Hebrew University of Jerusalem, Israel) and Antonio Granell (CSIC, Spain)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Manuel Rodriguez-Concepcion (IBMCP, Valencia, Spain)
"Phytoene Synthase: the Gatekeeper of Carotenoid Biosynthesis and Beyond"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Li Li (Agricultural Research Service, USDA / Cornell University, United States)
"Transcriptional and Translational Regulation of Carotenoid Biosynthesis in Plants"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Maria Lobato Gómez (Instituto de Biología Molecular y Celular de Plantas (IBMCP), Spain)
"Tomaffron: a Biotechnological Tomato Platform to Produce High Levels of Saffron Apocarotenoids"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Philip Kiser (UC Irvine and VA Long Beach, United States)
"Structure and Catalytic Mechanism of the Carotenoid Isomerooxygenase, NinaB"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
John Royer (DSM, United States)
"Honeysuckle Rhodoxanthin Synthase; From Red Berry To Novel Biochemical Pathway"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Niklas Steube (Max Planck Institute for Terrestrial Microbiology, Marburg, Germany, Germany)
"Fortuitous Origin of Allosteric Control in Cyanobacterial Photoprotection"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Eugenia Poliakov (Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, United States) and Nancy E. Moran (Baylor College of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vision and Carotenoids
Discussion Leader: Kevin McGraw (Arizona State University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Paul Bernstein (University of Utah, United States)
"Lutein and Zeaxanthin for Protection Against Ocular Disease: They’re Not Just for AMD Anymore"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
John Nolan (NRCI, Ireland)
"Xanthophyll Carotenoids for Eye and Brain: from the Cradle to the Dance Floor"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Malgorzata Rozanowska (Cardiff University, United Kingdom)
"Retinal Xanthophylls: from Effective Photoprotectants to Photosensitizers"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Linda Thomas (Case Western Reserve University, United States)
"Carotenoid Accumulation in ISX/BCO2 DKO Serves as a Macula Pigment Mouse Model"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Apocarotenoids and Signaling
Discussion Leaders: Alexandra Dickinson (UC San Diego, United States) and Jaume Amengual (University of Illinois at Urbana-Champaign, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Giovanni Giuliano (Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Italy)
"Apocarotenoid Biosynthesis Pathways and their Subcellular Compartmentation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
M. Mahmood Hussain (NYU Langone , United States)
"Role of MTP in Maternal/Placental Carotenoid Transfer"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Tal Makov (The Hebrew University of Jerusalem, Israel)
"Studying the Roles of Apocarotenoids In Tomato By Genome Editing of the Carotenoid Cleavage Dioxygenase (CCD) Genes"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Christopher Cazzonelli (Western Sydney University, Australia)
"Environmental Control of Apocarotenoid Signals and their Mechanism of Regulation in Plants"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Shipra Vaishnava (Brown University, United States)
"Regulation of Vitamin A Metabolism by the Gut Microbiome"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Juan Camilo Moreno Beltran (King Abdullah University of Science and Technology, Saudi Arabia)
"The Apocarotenoid Scent ß-ionone is a Regulatory Metabolite Affecting Arabidopsis Thaliana Transcriptome and Increasing its Resistance Against the Fungus Botrytis Cinerea"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Carotenoids and Photosynthesis
Discussion Leader: Krishna Niyogi (HHMI / University of California, Berkeley / Lawrence Berkeley National Laboratory, United States)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Roberto Bassi (University of Verona, Italy)
"Dissecting the Gene Family Encoding the Major Xanthophyll-chlorophyll a/b Antenna Proteins in Arabidopsis Thaliana"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Anja Liszkay (CNRS / CEA Saclay, France)
"Singlet Oxygen Production and Apocarotenoid Formation in Photosystem II"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Manuel Llansola-Portoles (CEA/CNRS/ University Paris-Saclay, France)
"Singlet Fission in Carotenoid Aggregates: from Chromoplasts to Bioinspired Artificial Systems"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biofortification and Biotechnology
Discussion Leader: Gianfranco Diretto (ENEA, Italy)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Sherry Tanumihardjo (University of Wisconsin-Madison, United States)
"Bioefficacy of Nixtamalized ß-Cryptoxanthin Biofortified Maize and a Novel ß-Cryptoxanthin Supplement"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Antonio Melendez-Martinez (Universidad de Sevilla, Spain)
"Carotenoids in the Sustainable and Health-promoting Food Era"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Eugenia Enfissi (Royal Holloway University of London, United Kingdom)
"The Development and Characterisation of Tomato Varieties with Enhanced High Provitamin A (beta-carotene) Ripe Fruit"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Libo Tan (University of Alabama, United States)
"Biopolymer Stabilized Emulsions Improved the Storage Stability, in vitro Bioaccessibility, and in vivo Bioavailability of Lutein in Neonatal Rats"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Sombir Rao (Cornell university, United States)
"A Moonlight Function of a NUDIX Hydrolase in Regulating Carotenoid Biosynthesis in Arabidopsis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Derry Alvarez (University of Lleida, Spain)
"Identification and Repair of Cis-acting Elements in the Endogenous Rice PSY1 Promoter to Restore Functionality in the Endosperm"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Retinoids and Apocarotenoids Metabolism
Discussion Leader: Jessica Cooperstone (The Ohio State University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Alexander R. Moise (Northern Ontario School of Medicine EAST, Canada)
"Role and Regulation of the Retinaldehyde Reductase DHRS3 in the Metabolism of Retinoids and Carotenoids."
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Claudia Stange (University of Chile, Chile)
"The Role of Light-regulated Genes in Carotenoid Synthesis in the Carrot Taproot"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Igor Shmarakov (Rutgers, The State University of New Jersey, United States)
"Pulmonary Retinoids and Acute Lung Injury"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Casey Cheng (UC San Diego, United States)
"The Changes in Root Structure of Zea Mays after Exogenous Application of the Apocarotenoid Hormones ?-Cyclocitral, Anchorene, and Retinaldehyde"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Carotenoids and Health
Discussion Leaders: Xiang-Dong Wang (Tufts University, United States) and Elizabeth Johnson (Tufts University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
John Erdman (University of Illinois at Urbana-Champaign, United States)
"What Do We Know about Mammalian Lycopene Metabolism?"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Ji-Young Lee (University of Connecticut, United States)
"Inhibitory Roles of Astaxanthin in Alcohol-induced Inflammation"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Anthony Miller (University of Illinois at Urbana-Champaign, United States)
"Characterization of the Bioactive Properties of Neurosporaxanthin: A Fungal Carotenoid with Provitamin A Activity in Mammals"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Abdulkerim Eroglu (North Carolina State University, United States)
"Harnessing Carotenoid Metabolism in the Gut Microbiota and Implications for Host Inflammation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Rachel Kopec (The Ohio State University, United States)
"Elucidating the Role of Carotenoids on Disease Outcomes - Building a Better Toolbox"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Nancy E. Moran (Baylor College of Medicine, United States)
"Validation of Skin Carotenoid Biomarkers for Use in Adults and Children"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Carotenoids and Microorganisms
Discussion Leaders: Johan Andersen-Ranberg (University of Copenhagen, Denmark)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
M Carmen Limon (University of Sevilla, Spain)
"Regulation of Neurosporaxnthin Production in Fusarium Fujikuroi"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Maiko Furubayashi (National Institute of Advanced Industrial Science and Technology (AIST), Japan)
"Engineering Natural and Non-natural Carotenoid/Apocarotenoid Pathways in Escherichia coli "
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Martin Lohr (Johannes Gutenberg-University Mainz, Germany)
"Functional Diversification of Carotenoid Isomerase-like Proteins in Algae"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Marcus Moldenhauer (Technische Universität Berlin, Germany)
"Parameterization of a single H-bond in the Orange Carotenoid Protein by atomic mutation using non-canonical amino acid substitutions"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure