| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CONTROL OF CARTILAGE DIFFERENTIATION |
| Discussion Leaders: David Ornitz (Washington University) & Cornelia Farnum (Cornell University) |
| 7:40 pm - 8:05 pm | Andy McMahon (Harvard University)
"Dissecting the Role of Wnt and Hedgehog Signaling in the Osteoblast Lineage" |
| 8:20 pm - 8:30 pm | Christine Hartmann (Vienna, Austria)
"Osteoblast or Chondrocyte - ß-catenin Levels Matter" |
| 8:30 pm - 8:55 pm | Karen Lyons (University of California at Los Angeles)
"BMP Signaling Pathways in the Growth Plate" |
| 9:10 pm - 9:20 pm | Lydia Koziel (Essen, Germany)
"Ext1 Dependent Heparan Sulfate Regulates the Range of Ihh Signaling" |
| 9:20 pm - 9:30 pm | Elazar Zelzer (Rehovot, Israel)
"The Role of HIF-1 and VEGF in Craniofacial Development" |
| 9:30 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TISSUE ENGINEERING AND MECHANICAL PROPERTIES OF CARTILAGE |
| Discussion Leaders: Robert Sah (University of California) & Alan Grodzinsky (MIT) |
| 9:00 am - 9:30 am | Qian Chen (Brown University)
"Mechanical Regulation of Osteochrondral Cell Lineage and Differentiation" |
| 9:45 am - 10:00 am | Robin Evans (Lausanne, Switzerland)
"Dynamic Compression Augments Glucose Transport in Articular Cartilage" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Ranieri Cancedda (University of Genova)
"Engineering of Cartilage from Cells" |
| 11:15 am - 11:30 am | Rocky Tuan (NIH)
"Application of Nanofibrous Scaffords for Cartilage Tissue Engineering" |
| 11:30 am - 12:00 pm | Michael Buschmann (Ecole Polytechnique)
“Biomaterial-induced Repair and Electromechanical Diagnostics of Articular Cartilage” |
| 12:15 pm - 12:30 pm | Karen King (University of California - San Francisco)
"Occupational Repetitive Stress and Cartilage" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | ROLE OF EXTRACELLULAR MATRIX IN CARTILAGE FUNCTION |
| Discussion Leaders: Dick Heinegard (Lund University) & Eero Vuorio (University of Turku) |
| 5:30 pm - 5:55 pm | Attila Aszodi (Max Planck Institute, Martinsried)
"All Roads Lead to the Matrix" |
| 6:10 pm - 6:35 pm | John Bateman (Murdoch Children's Research Institute, Melbourne)
"Cartilage Matrix Defects in Humans" |
| 6:45 pm - 7:00 pm | Martin Stolz (Basel, Switzerland)
Inspection of Articular Cartilage Biomechanics by indentation-type Scanning Force microscopy" |
| 7:00 pm - 7:15 pm | Anders Aspberg (University of Lund)
"Chondroitin Sulfate Perlecan Enhances Collagen Fibril Formation" |
| 7:15 pm - 7:30 pm | Shiro Ikegawa (University of Tokyo)
"Identification of Asporin as a Susceptibility Gene for Osteoarthritis" |
| 8:00 pm | Dinner |
| 9:30 pm | Posters |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MECHANISMS OF DIFFERENTIATION AND DEVELOPMENT |
| Discussion Leaders: Veronique Lefebvre (Cleveland Clinic Foundation) & Andrew Lassar (Harvard University) |
| 9:00 am - 9:25 am | Bjorn Olsen (Harvard University)
"The Interphase between Bone Formation and Chondrogenesis: A New Role for VEGF" |
| 9:40 am - 9:55 am | Jane Lian (University of Massachusetts)
"Developmental Regulation of Runx2 from Chondrogenesis to Osteogenesis" |
| 9:55 am - 10:10 am | Fanxin Long (Washington Unviersitu)
"Roles of Gli3 in Mediating Ihh Signaling in the Endochondral Skeleton" |
| 10:10 am | Coffee Break |
| 10:30 am - 11:00 am | Michael Wegner (University of Erlangen)
"Sox proteins: their life beyond cartilage" |
| 11:15 am - 11:30 am | Hiroshi Asahara (Scripts Institute)
"Chromatin -dependent Regulation of Chondrogenesis" |
| 11:45 am - 12:15 pm | Charles Archer (Cardiff University)
"Development of Articular Cartilage" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | THE FUTURE OF CARTILAGE RESEARCH: A Sampling |
| Discussion Leaders: Andrea Vortkamp (Ruhr University) & Hari Reddi (University of California) |
| Faye Chen (NIH)
"The Role of COMP in Cartilage Biology and its Interaction with Chondrocytes" |
| H. Akihama (Kyoto University)
"Transcriptional Control of Type II Procollagen: Role of ß-Catenin" |
| Audrey McAlinden (Washington University)
"Post-transcriptional Control of Type II Procollagen Spice Forms" |
| Rosa Serra (University of Alabama)
"Role of TGFß in Chondrogenesis" |
| Ernestina Schipani (Harvard University)
"Vegf, Hif and Cartilage" |
| Yingzi Yang (NIH)
"The canonical Wnt signaling controls synovial joint formation and differentiation of osteoblasts and chondrocytes from mesenchymal progenitors during vertebrate skeletal development" |
| 8:00 pm | Dinner |
| 9:30 pm | Posters |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MOLECULAR MECHANISMS OF CARTILAGE DEGRADATION |
| Discussion Leaders: Liz Arner (Pfizer) & Elizabeth Morris (Wyeth) |
| 9:00 am - 9:30 am | A. Robin Poole (McGill University, Shriner's Hospital)
"The Onset of Osteoarthritis and its Progression Involves a Loss of Balance Between Cartilage Matrix Synthesis and Degradation" |
| 9:45 am - 10:00 am | Donald Salter (Edinburgh Royal Infirmary)
"Integrin Regulates Aggrecan Gene Expression by Osteoarthritic Human Articular Chondrocytes" |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Amanda Fosang (University of Melbourne)
"ADAMTS-5 is the major aggrecanase in cartilage: studies with ADAMTS-4 and ADAMTS-5 deficient mice" |
| 11:00 am - 11:20 am | Sonja Glasson (Wyeth)
"Single Gene Deletion for Osteoarthritis Target Identification: Answers and Questions from ADAMTS, MMP, Cytokine KO Mice" |
| 11:30 am - 11:45 am | Anne-Marie Malfait (Pfizer, St. Louis, MO)
"Identification of the proprotein convertase that initiates aggrecan catabolism" |
| 11:50 am - 12:30 pm | Suneel Apte (The Cleveland Clinic Foundation)
"New Functions for ADAMTS Proteases in Skeletal Tissues" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | PATHOGENESIS OF CARTILAGE DEGENERATION |
| Discussion Leader: David Eyre (University of Washington) |
| 5:30 pm - 6:00 pm | David Rimoin, M.D.
“Molecular Mechanisms of Chondrodysplasias” |
| 6:15 pm - 7:30 pm | Special Lecture: Stephen Krane (Harvard Medical School)
"MMPs: Key Effectors of Skeletal Biology" |
| 8:00 pm | Dinner |
| 9:30 pm | Reception |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
