SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Meeting Chairs |
7:40 pm - 9:30 pm | DEVELOPMENT / EVOLUTION OF CARTILAGE |
| Discussion Leader: Karen Lyons (University of California, Los Angeles) |
7:40 pm - 8:05 pm | Raymond Boot-Handford (University of Manchester, UK)
"The Evolution Of Cartilage" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Ryan Kerney (Dalhousie University, Canada)
"Thinking Outside The Mouse: De-Novo Cartilage Formation During Amphibian Metamorphosis" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Matthew Harris (Max Planck Institute for Developmental Biology, Germany)
"The Zebrafish as a Genetic Model to Understand Developmental Mechanisms Underlying Patterning of the Adult Skeleton" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SIGNALING AND CONTROL MECHANISMS |
| Discussion Leader: Andrea Vortkamp (University Duisburg-Essen, Germany) |
9:00 am - 9:25 am | Fanxin Long (Washington University Medical School, USA)
"Intercellular Signals Controlling Bone Formation" |
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Andrew Dudley (Northwestern University, USA) "Chondrocyte polarity and the regulation of cartilage morphogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:55 am | Elazar Zelzer (Weizmann Institute of Science, Israel)
"Struggling for Harmony- Skeletal Development as Part of the Musculoskeletal System" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Susan Mackem (National Institutes of Health, National Cancer Institute, USA)
"Dissecting the Regulation of Limb Skeletal Patterning and Morphogenesis with Conditional Genetic Approaches" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Stefan Mundlos (Max Planck Institute for Molecular Genetics, Germany)
"A Network of Transcription Factors Regulate Bone Formation in the Limb" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | GENETIC MECHANISMS OF DISEASE |
| Discussion Leader: Matthew Warman (Children's Hospital, Boston, USA) |
5:30 pm - 5:55 pm | Patrick Smits (Children’s Hospital, Boston, USA) "Mutations in the Golgin TRIP11 cause lethal skeletal dysplasias in mouse and human" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Christine Hartmann (Research Institute of Molecular Pathology, Austria)
"Loss of Wnt Signaling Causes Osteoarthritis" |
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Shiro Ikegawa (Center for Genomic Medicine, RIKEN, Japan)
"From Mouse to Human, from Monogenic to Polygenic Disease" |
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MOLECULAR STRUCTURE |
| Discussion Leader: Erhard Hohenester (Imperial College London, UK) |
9:00 am - 9:25 am | Hideaki Nagase (Imperial College London, Kennedy Institute of Rheumatology, UK)
"Interaction of TIMP-3 and Aggrecanases" |
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Andreas Tagariello (University Erlangen, Germany) "Further functional characterization of UCMA" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Anthony Day (The University of Manchester, UK)
"Hyaluronan-protein interactions in joint inflammation" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Erhard Hohenester (Imperial College London, UK)
"Structural Basis of Sequence-Specific Collagen-Protein Interactions" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Anders Aspberg (University of Copenhagen, Denmark)
"Functional Roles of the Aggrecan C-type Lectin" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | MECHANOBIOLOGY |
| Discussion Leader: Christopher S. Chen (University of Pennsylvania, USA) |
5:30 pm - 5:55 pm | Dennis Discher (University of Pennsylvania, USA)
"Cell Mechanics, Matrix and Differentiation" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:20 pm | Efrat Monsonego Ornan (Hebrew University, Israel) "Multiple pathways mediating mechano-signaling in the growth-plate" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Dean Wang (National Institute of Arthritis, and Musculoskeletal & Skin Diseases, National Institutes of Health, USA) "Gene Therapy with Parathyroid Hormone-related Protein Protects Chondrocytes from Cyclic Tensile Strain-induced Injury" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Sudha Agarwal (The Ohio State University, USA)
"Biomechanical Control of Chondrocyte Signaling" |
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DEGENERATIVE DISORDERS |
| Discussion Leader: Amanda Fosang (University of Melbourne and Murdoch Childrens Research Institute, Australia) |
9:00 am - 9:25 am | Elisabeth Morris (Articular Therapeutics, Wyeth Research, USA)
"Therapeutic Targets in Osteoarthritis" |
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Stephanie Gauci (Royal Children's Hospital, Australia) "Growth Plate Chondrocytes From Collagen II Knockin Mice (Bailey) Exhibit Inappropriate Terminal Differentiation" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Yefu Li (Harvard School of Dental Medicine, USA)
"Molecular Mechanisms of Progression in Osteoarthritis" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Tonia L. Vincent (Kennedy Institute of Rheumatology, UK)
"Intrinsic Chondroprotective Pathways" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Danny Chan (The University of Hong Kong, Hong Kong)
"Developmental and Genetic Aspects of Intervertebral Disc Degeneration" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | CELLULAR MECHANOBIOLOGY AND IMMUNE MECHANISMS IN DISEASE |
| Discussion Leader: Rocky Tuan (National Institute of Arthritis, and Musculoskeletal & Skin Diseases, National Institutes of Health, USA) |
5:30 pm - 6:10 pm | Rikard Holmdahl (Lund University, Sweden)
"Pathogenic Autoimmune Recognition of Cartilage" |
6:10 pm - 6:30 pm | Discussion |
6:30 pm - 7:10 pm | Christopher S. Chen (University of Pennsylvania, USA)
"Mechanotransduction in Stem Cell Differentiation" |
7:10 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | REPAIR, REGENERATION AND TISSUE ENGINEERING |
| Discussion Leader: Vicki Rosen (Harvard School of Dental Medicine, USA) |
9:00 am - 9:25 am | Rocky Tuan (National Institute of Arthritis, and Musculoskeletal & Skin Diseases, National Institutes of Health, USA)
"Adult Stem Cells and Nanomaterials in Cartilage Tissue Engineering and Regeneration" |
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Sebastian Koelling (Georg August University, Germany) "Migratory Chondrogenic Progenitor Cells From Late Stages of Osteoarthritis Exhibit Gender Differences" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Ichiro Sekiya (Tokyo Medical and Dental University, Japan)
"Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Damian Medici (Harvard School of Dental Medicine, USA) "Vascular Endothelial Transdifferentiation to Multipotent Mesenchymal Stem-like Cells" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Jeroen Leijten (University of Twente, The Netherlands) "Discriminating Growth Plate from Articular Cartilage" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Anthony Hollander (University of Bristol, UK)
"Claudia's Trachea: Engineering and Implantation of an Airway and Implications for Other Cartilage Sites" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | NEW DIRECTIONS |
| Discussion Leader: Kathryn Cheah (The University of Hong Kong, Hong Kong) |
5:30 pm - 5:55 pm | David Cox (Biotherapeutics and Bioinnovation Center, Pfizer Inc., USA)
"Genetic Risk Factors in Disease and Therapeutic Targets" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:25 pm | Chris Murphy (Imperial College, UK) "The role of microRNAs in chondrocyte function" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 6:55 pm | Martin Stolz (Biozentrum/University of Basel) "Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:20 pm | Patrik Onnerfjord (Lund University, Sweden) "Quantitative proteomics of different human cartilage subtypes reveals unique patterns of protein composition" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |