SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Development / Evolution of Cartilage |
| Discussion Leader: Andrea Vortkamp (University of Duisberg-Essen, Germany) |
7:40 pm - 8:05 pm | Shigeru Kuratani (RIKEN Center for Developmental Biology, Japan) "Craniofacial development of the cyclostome and evolution of the vertebrate body plan" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Rich Schneider (University of California, San Francisco, USA) "Mechanisms of Cartilage Patterning During Development and Evolution" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Veronique Lefebvre (Cleveland Clinic and Case Western Reserve, USA) "Roles and regulation of Sox genes in chondrogenesis" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling and Control Mechanisms in Cartilage |
| Discussion Leader: Ernestina Schipani (Massachusetts General Hospital, USA) |
9:00 am - 9:20 am | Mathew Hilton (University of Rochester, USA) "Multiple Roles of the Notch Signaling Pathway During Chondrogenesis and Chondrocyte Maturation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Xiangli Yang (Vanderbilt University, USA) "ATF4 in chondrocytes regulates osteoblast function" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:55 am | Hank Kronenberg (Massachusetts General Hospital, USA) "How PTHrP regulates growth plate chondrocytes" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Hiroshi Asahara (NRICHD, Japan, and The Scripps Research Institute, USA) "Transcription and RNA network regulating locomotive system development and homeostasis" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Chris Murphy (Imperial College, UK) "MicroRNAs - aiming for targets" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic Analysis of Skeletal and Metabolic Disorders |
| Discussion Leader: Philip Beales (University College London, UK) |
7:30 pm - 7:50 pm | Deborah Krakow (University of California, Los Angeles, USA) "FGFs and skeletal dysplasia" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Daniel Cohn (Cedars-Sinai Medical Center, Los Angeles, USA) "Type XI collagen defects in fibrochondrogenesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Brendan Lee (Baylor College of Medicine, USA) "Novel signaling mechanisms during chondrogenesis" |
8:50 pm - 9:00 pm | Discussion |
9:10 pm - 9:20 pm | Shireen Lamande (Royal Children’s Hospital, Australia) "Mutations in TRPV4 cause an inherited arthritis of hands and feet" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cartilage Organization |
| Discussion Leader: Regis O’Keefe (University of Rochester, USA) |
9:00 am - 9:20 am | Dick Heinegard (Lund University, Sweden) "Implications of differences in molecular constituents within and between cartilages" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Kevin Jones (University of Utah, USA) "Chondrocyte polarity in osteochondromagenesis and malignant transformation" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Atilla Aszodi (Ludwig-Maximillians-University, Germany) "Mechanisms controlling chondrocyte polarity" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Yingzi Yang (National Institutes of Health, USA) "Wnt5a controls directional growth of the cartilage by acting as a global cue to establish planar cell polarity" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Jessica Bertrand (Queen Mary University, UK) "NPP1 deficient mice exhibit OA-like changes and cartilage remodeling into bone" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cellular Stress in Cartilage |
| Discussion Leader: Linda Sandell (Washington University, USA) |
7:30 pm - 7:50 pm | Ben Alman (University of Toronto, Canada) "From development to pathology: Hedgehog signalling in cartilage neoplasia and osteoarthritis" |
7:50 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Mike Briggs (University of Manchester, UK) "Mechanisms of chondrocyte stress caused by mutations in COMP and MATN3" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Frank Beier (University of Western Ontario Canada) "Stress pathways in endochondral ossification and osteoarthritis" |
9:00 pm - 9:15 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Degenerative Disorders |
| Discussion Leader: Danny Chan (University of Hong Kong) |
9:00 am - 9:20 am | Makarand Risbud (Thomas Jefferson University, USA) "Molecular Mediators of TNF-alpha and IL-1beta Action on the Nucleus Pulposus Cells: Implications in Degenerative Disc Disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Linda Sandell (Washington University, USA) "Genetic Mouse Models for Cartilage Repair and Degeneration" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Ernestina Schipani (Massachusetts General Hospital, USA) "HIF and VHL in cartilage: a tale of paradoxes" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Hiroshi Kawaguchi (University of Tokyo, Japan) "Endochondral ossification signals as potential therapeutic targets for osteoarthritis" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Thomas Pap (University Hospital Munster, Germany) "Regulation of chondrocyte metabolism and cartilage breakdown by syndecans" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Inflammatory Mechanisms |
| Discussion Leader: Roy Black (Amgen, Seattle, USA) |
7:30 pm - 7:40 pm | Roy Black (Amgen, Seattle, USA) "Blocking the LRP-1-mediated clearance of TIMP-3 prevents cytokine-induced cartilage degradation" |
7:40 pm - 7:50 pm | Discussion |
7:50 pm - 8:10 pm | Konstantin Taganov (Regulus Therapeutics, Carlsbad, USA) "microRNA-146A is a Significant Brake on Autoimmunity Myeloproliferation and Cancer in Mice" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Joyce Wu (Harvard University, USA) "A link between gut microbiota, mucosal immunity and autoimmune arthritis" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Ru Liu-Bryan (University of California, San Diego, USA) "Innate Immunity in chondrocyte function and differentiation" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Repair, Regeneration, Tissue Engineering |
| Discussion Leader: Rocky Tuan (University of Pittsburgh, USA) |
9:00 am - 9:20 am | Regis O’Keefe (University of Rochester, USA) |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Bjorn Olsen (Harvard University, USA) "Mesenchymal stem-like cells from vascular endothelium - the good and the bad"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Samuel Stupp (Northwestern University, USA) "Bioactive Nanostructures for the Regeneration of Tissues" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Daisuke Sakai (Tokai University, Japan) "Identification and characterization of stem/progenitor population from nucleus pulposus of the intervertebral disc" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Rita Kandel (University of Toronto, Canada) "Engineering intervertebral discs" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Enabling Technologies for Cartilage Research |
| Discussion Leader: Bjorn Olsen (Harvard University, USA) |
7:30 pm - 7:55 pm | John Loughlin (Newcastle University, UK) "Osteoarthritis susceptibility loci emerging from genome-wide association scans" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Faisal Aldaye (Harvard University, USA) "A structurally and functionally tunable DNA extracellular matrix" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Shinsuke Ohba (Univeristy of Tokyo, Japan) "Application of ChIP-Seq combined with a novel genetic tool to skeletal biology" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |