SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Cartilage Diseases |
| Discussion Leader: Benjamin Alman (Hospital for Sick Children, Toronto, Canada) |
7:40 pm - 8:00 pm | Matthew Warman (Children's Hospital, Boston, USA)
"Can cartilage damage be prevented, delayed, improved, or reversed"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Tracy Ballock (Cleveland Clinic, USA)
"Diseases of Cartilage Growth"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Richard Loeser (Wake Forest University School of Medicine, USA)
"Cartilage Pathogenesis in Osteoarthritis"
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9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cellular Commitment and Developmental Modeling |
| Discussion Leader: Henry Kronenberg (Massachusetts General Hospital, Boston, USA) |
9:00 am - 9:20 am | Elazar Zelzer (Weizmann Institute of Science, Israel)
"Shaping of the Skeleton by Distinct Pools of Cartilage Progenitors"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Dagmar Iber (ETH, Basel, Switzerland)
"Mathematical Modeling of Long Bone Growth and Development"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Andrew McMahon (Harvard University, Boston, USA)
"Transcriptional programs in the chondrocyte"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Andrew Lassar (Harvard University, Boston, USA)
"Regulation of phenotypic plasticity, hedgehog signaling, and cell fate during early cartilage development"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Short Talks |
11:30 am - 11:45 am | Pallavi Bhattaram (Cleveland Clinic, USA)
"Critical roles for the SoxC Transcription Factors in Skeletogenesis"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Manuela Wuelling (University of Duisburg-Essen, Germany)
"The Multi Zinc-Finger Protein Trps1 Acts as a Regulator of Histone Deacetylation during Mitosis"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Developmental Regulation |
| Discussion Leader: Yingzi Yang (NIH, USA) |
5:30 pm - 5:50 pm | Karen Lyons (University of California, Los Angeles, USA)
"BMP and CTGF Signaling in Cartilage Development"
|
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | David Clouthier (University of Colorado, USA)
"Signaling Pathways Regulating Craniofacial Development"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 7:15 pm | Short Talks |
6:30 pm - 6:40 pm | Harald Ehlen (University of Cologne, Germany)
"Identification of a Posttranscriptional Regulator of Chondrocyte Differentiation"
|
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Louise Reynard (Newcastle University, UK)
"Functional Analysis of the Osteoarthritis Susceptibility Locus Residing at the Carbohydrate Sulfotransferase 11 Gene CHST11"
|
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Michael Pest (University of Western Ontario, Canada)
"Development of Osteoarthritis and Disruption of Knee Joint Morphology in a Cartilage-Specific Mig-6 Deletion Mouse"
|
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:30 pm | General Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Growth Plate and Endochondral Ossification |
| Discussion Leader: Ernestina Schipani (Indiana University, USA) |
9:00 am - 9:20 am | Laurence Legeai-Mallet (INSERM, France)
"Overview on FGFR3-related diseases: From gene to therapeutic approaches"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Christa Maes (KU Leuven, Belgium)
"VEGF and Hypoxia-Driven Pathways in Cartilage and Bone Development"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Kay Grobe (University of Muenster, Germany)
"Heparan Sulfate and Hedgehog Signaling in Chondrocytes"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 12:10 pm | Short Talks |
11:00 am - 11:10 am | Angus Wann (University of London, UK)
"Recruitment of Hypoxia-Inducible Factor 2a to the Chondrocyte Primary Cilium: The Ciliary Link between Cytokines and HIF"
|
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Efrat Monsonego Ornan (Hebrew University, Israel)
"The Effect of Obesity on the Postnatal Skeleton Development"
|
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Klaus von der Mark (University of Erlangen-Nuernburg, Germany)
"Col10 Transgenic Mice Reveal Transdifferentiation of Chondrocytes in Bone Marrow Stem Cells and Osteoblasts"
|
11:45 am - 12:00 pm | Kathy Cheah (University of Hong Kong, China)
"Hypertrophic Chondrocytes Can Become Osteoblasts and Osteocytes in Endochondral Bone Formation"
|
12:00 pm - 12:10 pm | Combined Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Cartilage and Associated Tissues |
| Discussion Leader: Christine Hartmann (University of Muenster, Germany) |
5:30 pm - 5:50 pm | Brian Harfe (University of Florida, USA)
"Formation and Maintenance of the Intervertebral Discs"
|
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Ronen Schweitzer (Portland Shriners Hospital, USA)
"Molecular Regulation of Tendon Development"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Stavros Thomopoulos (Washington University, USA)
"Development of the fibrocartilaginous interface at the tendon-to-bone attachment"
|
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Short Talks |
7:00 pm - 7:15 pm | Jake Bedore (University of Western Ontario, Canada)
"CCN2 Secreted from Notochord-Derived Cells Regulates Intervertebral Disc Development and Protects from Age-Related Disc Degeneration"
|
7:15 pm - 7:20 pm | Discussion |
7:20 pm - 7:30 pm | General Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Function and Dysfunction |
| Discussion Leader: Veronique Lefebvre (Cleveland Clinic, USA) |
9:00 am - 9:20 am | Robert Sah (University of California, San Diego, USA)
"Joint Lubrication and Articular Cartilage (Dys)Function"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Melissa Knothe Tate (Case Western Reserve University, USA)
"Skeletal Mechanobiology"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Rosa Serra (University of Alabama, USA)
"Role of Primary Cilia in Chondrocyte Biology"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Amanda Fosang (University of Melbourne, Australia)
"Bioactivity in an aggrecan 32mer fragment"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Short Talks |
11:30 am - 11:40 am | Jeroen Leijten (University of Twente, Netherlands)
"GREM1, FRZB and DKK1 are Involved in Joint Homeostasis, Hypertrophic Differentiation and Osteoarthritis"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Attila Aszodi (Clinical Center, University of Munich, Germany)
"Beta-1 Integrin Deficiency in Mice Impairs the Surface Properties of Articular Cartilage"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Masahiro Iwamoto (Children's Hospital of Philadelphia, USA)
"Roles of ets-Transcription Factors in Formation and Maintenance of Permanent Articular Cartilage" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | Degeneration and Regeneration |
| Discussion Leader: Frank Beier (University of Western Ontario, Canada) |
5:30 pm - 5:50 pm | Wiltrud Richter (University of Heidelberg, Germany)
"Molecular Mechanisms of Osteoarthritis"
|
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Martin Lotz (Scripps Institute, USA)
"Therapeutic Targets in Cartilage Degeneration"
|
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Lisa Fortier (Cornell University, USA)
"Cartilage Degeneration and Regeneration in the Equine Articular Joint"
|
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Short Talks |
7:00 pm - 7:10 pm | Hui Wang (Newcastle University, UK)
"Tribble 3 Deficiency Protects Against Cartilage Damage in a Murine Model of Osteoarthritis"
|
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:30 pm | General Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Cell-based Therapies and Technologies |
| Discussion Leader: Bjorn Olsen (Harvard University, Boston, USA) |
9:00 am - 9:20 am | Rita Kandel (Mount Sinai Hospital, Toronto, Canada)
"What cells should we use for cartilage repair: stem cells or chondrocytes?"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Hongwei Ouyang (Zheijang University, China)
"Application and identification of CPCs for cartilage repair"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Noriyuki Tsumaki (Kyoto University, Japan)
"Modeling type II collagenopathy by directed conversion and iPS cells"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 12:15 pm | Short Talks |
11:00 am - 11:10 am | April Craft (University Health Network, Toronto, Canada)
"Specification of paraxial mesoderm and chondrocytes from pluripotent stem cells results in articular and growth plate like-cartilage"
|
11:10 am - 11:15 am | Discussion |
11:15 am - 11:30 am | TBA
|
11:30 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Solvig Diederichs (University of Pittsburgh, UK)
"Human iPS Cell-Derived Mesenchymal Cells Are Not Identical to Bone Marrow-Derived Mesenchymal Stem Cells"
|
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Nicolai Miosge (University of Goettingen, Germany)
"Chondrogenic Progenitor Cells are Key Players in the Regeneration of Cartilage Tissue"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | Keynote Lecture |
| Discussion Leader: Danny Chan (University of Hong Kong, China) |
5:40 pm - 6:40 pm | Dennis Duboule (University of Geneva, Switzerland)
"Regulation of Hox D Genes During Skeletal Patterning"
|
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:30 pm | General Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |