| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Introduction to Cartilage, from Biology to Pathology |
| Discussion Leader: Linda Sandell (Washington University in St. Louis, USA) |
| 7:40 pm - 7:45 pm | Introduction by Discussion Leader |
| 7:45 pm - 8:10 pm | Yingzi Yang (Harvard School of Dental Medicine, USA)
"Global Cues Establish Planar Cell Polarity for Directional Growth of the Cartilage" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Christopher Little (University of Sydney, Australia)
"Whole-Joint
Pathology in Osteoarthritis" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Francesca Mariani (University of Southern California, USA)
"Large-Scale Cartilage Repair in a Mouse Model" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | General Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Origin and Regulation of Chondroprogenitors in Development |
| Discussion Leader: Elazar Zelzer (Weizmann Institute of Science, Israel) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:25 am | Lukas Sommer (University of Zurich, Switzerland)
"Development
of Craniofacial Structures from Neural Crest Stem Cells" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Alex Nord (University of California, Davis, USA)
"Genomic Characterization of Craniofacial Development" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:35 am | Coffee Break |
| 10:35 am - 10:55 am | Michael Underhill (University of British Columbia, Canada)
"Diverse
Origins of Mesenchymal Cells in the Developing Limb" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:25 am | Elly Tanaka (Center for Regenerative Therapies Dresden, Germany)
"Regenerating a Patterned Limb" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:50 am | Thomas Lozito (University of Pittsburgh, USA)
"Lizard Tail Skeletal Regeneration Combines Aspects of Fracture Healing and Blastema-Based Regeneration" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Bau-Lin Huang (National Cancer Institute, USA)
"Interdigital Mesenchyme Acts as a Signaling Center, Governed by 5’Hoxd-Gli3 Antagonism, to Instruct Digit Joint Formation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Identification of Adult Chondroprogenitors to Repair Cartilage Defects |
| Discussion Leader: Martin Lotz (The Scripps Research Institute, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | George Muschler (Cleveland Clinic Foundation, USA)
"Sourcing
of Human Chondroprogenitors" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Cosimo De Bari (University of Aberdeen, United Kingdom)
"Mesenchymal
Stem Cells Find Their Niche in Cartilage Repair" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:50 pm | Yulia Shwartz (Weizmann Institute of Science, Israel)
"Growth and Differentiation Factor-5 (Gdf5)-Positive Cells Are Constantly Join(t)ing the Party" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Rebekah Decker (Children's Hosptial of Philadelphia, USA)
"New Insights into Mouse Limb Synovial Joint Morphogenesis Using Novel Cell Lineage Tracing Techniques" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | General Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cartilage Primordia and Growth Plates in Development and Disease |
| Discussion Leader: Ernestina Schipani (University of Michigan, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:25 am | Andrew Pitsillides (Royal Veterinary College, United Kingdom)
"Defining
Critical Periods and Pathways in Skeletal Mechanosensitivity in Embryonic
Limbs" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Philippe Soriano (Mount Sinai School of Medicine, USA)
"Receptor
Tyrosine Kinase Signaling Pathways in Skeletal Development" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:35 am | Coffee Break |
| 10:35 am - 10:55 am | Wentian Yang (Brown University Alpert Medical School, USA)
"Role of
the Protein Tyrosine Phosphatase SHP2 in Cartilage Development and Diseases" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:25 am | Audrey McAlinden (Washington University in St. Louis, USA)
"Regulation
of Chondrocyte Differentiation by MicroRNAs" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:50 am | Jacqueline Norrie (The University of Texas, Austin, USA)
"Dynamics of Bone Morphogenetic Protein (BMP) Signaling in Limb Bud Mesenchyme and Polydactyly" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Diana Rigueur (University of California, Los Angeles, USA)
"Challenging the Dogma of Bone Morphogenetic Protein (BMP) in the Absence of Smad4" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Approaches to Uncover Disease Causes, Mechanisms and Treatments |
| Discussion Leader: Benoit De Crombrugghe (University of Texas M.D. Anderson Cancer Center, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Biagio Saitta (Cedars-Sinai Medical Center, USA)
"Modelling TRPV4 Skeletal Dysplasia Using Patient-Derived Induced Pluripotent Stem Cells" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Benjamin Alman (Duke University, USA)
"Mutations in the Isocitrate
Dehydrogenase Genes IDH1 and IDH2 Are Sufficient to Cause Enchondromatosis" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:50 pm | Noriyuki Tsumaki (Kyoto University, Japan)
"Generation of Scaffold-Less Hyaline Cartilaginous Tissue from Human Induced Pluripotent Stem Cells" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | James Harding (University of California, Los Angeles, USA)
"The First Automated Method for Detection and Morphometry of Chondrocytes" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | General Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Articular Chondrocyte Regulation from Development to Adult Disease |
| Discussion Leader: Mary Goldring (Hospital for Special Surgery, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:25 am | Anna Spagnoli (Rush University Medical Center, USA)
"Lesson from Joint Development: Rationale for a New Paradigm Shift in Osteoarthritis" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Jang-Soo Chun (Gwangju Institute Science and Technology, South Korea)
"Novel Transcriptional Networks in Osteoarthritis Pathogenesis" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:35 am | Coffee Break |
| 10:35 am - 10:55 am | Kristen Johnson (Genomics Institute of the Novartis Research Foundation, USA)
"Cartilage Injuries and Repair: New Approaches and Potential Therapeutics" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:25 am | Rajesh Kamath (AbbVie, Inc., USA)
"Modulation of the Interleukin-1 Axis for Osteoarthritis Using Dual Variable Domain-Immunoglobulin Technology" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:50 am | Miguel Otero (Hospital for Special Surgery, USA)
"Mice with a Cartilage-Specific Knockout of the Nuclear Factor Kappa-B Kinase Subunit Alpha (IKK?) Are Protected from Cartilage Degradation Following Surgical Induction of Osteoarthritis" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Andreia Ionescu (Harvard University School of Dental Medicine, USA)
"Identification of Forkhead Box A2 (FoxA2) as a Novel Target in the Onset and Development of Osteoarthritis" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Intervertebral Disc Regulation from Development to Adult Disease |
| Discussion Leader: Makarand Risbud (Thomas Jefferson University, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Daisuke Sakai (Tokai University School of Medicine, Japan)
"Intervertebral Disc Cell Regulation from Development to Adult Disease" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Cheryle Seguin (University of Western Ontario, Canada)
"Mechanisms Underlying Ectopic Mineralization in Diffuse Idiopathic Skeletal Hyperostosis" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:50 pm | Akansha Shah (University of Hong Kong, Hong Kong SAR China)
"The Role of Hypertrophic Chondrocytes and Cellular Stress in Intervertebral Disc Integrity and Degeneration" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Laura Mangiavini (University of Michigan, USA)
"Fibrosis and Hypoxia-Inducible Factor 1-Alpha (HIF-1α)-Dependent Tumors of the Soft Tissue upon Loss of Von Hippel Lindau Protein (VHL) in Mesenchymal Progenitors" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | General Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structural and Functional Crosstalks Between Cartilage and Other Tissues |
| Discussion Leader: Henry Kronenberg (Massachusetts General Hospital, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:25 am | Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Coupling of Angiogenesis and Osteogenesis in Bone" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Henry Kronenberg (Massachusetts General Hospital, USA)
"Growth-Related Bone Progenitor Cells" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:35 am | Coffee Break |
| 10:35 am - 10:55 am | Deneen Wellik (University of Michigan Medical Center, USA)
"A Reserve Hox-Expressing Population Is Critical for Adult Musculoskeletal Repair" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:25 am | Vicki Rosen (Harvard School of Dental Medicine, USA)
"Characterization
of Meniscal Stem Cells in Adult Meniscus" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:50 am | Amy Merrill-Brugger (University of Southern California, USA)
"Where Tendon Meets Bone: A Role for Fibroblast Growth Factor Receptor-2 (Fgfr2) at the Site of Attachment" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Scott Stadler (Shriners Hospital / Oregon Health Sciences University, USA)
"Epigenetic Regulation of Chondrogenesis by a Novel Long Non-Coding RNA" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Insights from Genome-Wide Studies on Skeletal Traits and Diseases |
| Discussion Leader: Bjorn Olsen (Harvard School of Dental Medicine, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Kalliope Panoutsopoulou (Wellcome Trust Sanger Institute, United Kingdom)
"Genome-Wide Association Studies of Extensive Osteoarthritis-Related Phenotypes" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Joel Hirschhorn (Boston Children's Hospital, USA)
"Insights into Human Skeletal Growth from Genetic Studies of Adult Height" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:50 pm | Anusha Ratneswaran (Western University, Canada)
"Peroxisome Proliferator-Activated Receptor Delta (PPARδ) Promotes the Progression of Post-Traumatic Osteoarthritis" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Takako Hattori (Okayama University, Japan)
"The Ubiquitin Ligase E6-AP/UBE3A Targets SOX9 Protein and Is Essential for Endochondral Ossification" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | General Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
